STRINGSTRING
TNF TNF MAP3K10 MAP3K10 EPHA4 EPHA4 MAP2K6 MAP2K6 PAK1 PAK1 NTF3 NTF3 IL34 IL34 SASH1 SASH1 ERP29 ERP29 EZH2 EZH2 HRAS HRAS ERN2 ERN2 AGER AGER SYK SYK DKK1 DKK1 INSR INSR TNFSF11 TNFSF11 ELANE ELANE FLT1 FLT1 IRAK1 IRAK1 MAP3K4 MAP3K4 EDN1 EDN1 ROR2 ROR2 FZD4 FZD4 KIT KIT MAP3K5 MAP3K5 NEK10 NEK10 CCL19 CCL19 AKAP13 AKAP13 FGF2 FGF2 TRAF2 TRAF2 PDE5A PDE5A ENSRBIP00000031653 ENSRBIP00000031653 AJUBA AJUBA ERBB2 ERBB2 MIF MIF LOC108516810 LOC108516810 FGD2 FGD2 MEF2C MEF2C MST1R MST1R ENSRBIP00000034301 ENSRBIP00000034301 MAGED1 MAGED1 AXIN1 AXIN1 TENM1 TENM1 CD40 CD40 MAP3K11 MAP3K11 TRAF6 TRAF6 LOC108525089 LOC108525089 MAP2K7 MAP2K7 LOC108524385 LOC108524385 ENSRBIP00000037030 ENSRBIP00000037030 ENSRBIP00000037360 ENSRBIP00000037360 EGFR EGFR FGF18 FGF18 FLT3 FLT3 MAP4K2 MAP4K2 MAP2K5 MAP2K5 PTPRC PTPRC TPD52L1 TPD52L1 PIK3CG PIK3CG WNT5A WNT5A THBS1 THBS1 HTR2B HTR2B ENSRBIP00000042593 ENSRBIP00000042593 ENSRBIP00000043094 ENSRBIP00000043094 RPS3 RPS3 PIK3R5 PIK3R5 PDCD10 PDCD10 SRC SRC PTPN1 PTPN1 ENSRBIP00000002430 ENSRBIP00000002430 ENSRBIP00000002994 ENSRBIP00000002994 NOD2 NOD2 ENSRBIP00000004022 ENSRBIP00000004022 PSEN1 PSEN1 FZD5 FZD5 MAP3K7 MAP3K7 FZD10 FZD10 TLR4 TLR4 TGFB1 TGFB1 PLA2G1B PLA2G1B ENSRBIP00000006958 ENSRBIP00000006958 ROBO1 ROBO1 ADAM9 ADAM9 CSK CSK TNFRSF11A TNFRSF11A FGF1 FGF1 DVL3 DVL3 DUSP19 DUSP19 CEACAM1 CEACAM1 P2RX7 P2RX7 ENSRBIP00000011851 ENSRBIP00000011851 MAP3K12 MAP3K12 LRRK2 LRRK2 EPGN EPGN PTK2B PTK2B PDGFC PDGFC S100A12 S100A12 DAB2IP DAB2IP MAP3K13 MAP3K13 RASGRP1 RASGRP1 TGFA TGFA PIK3R6 PIK3R6 PDGFRB PDGFRB LOC108539701 LOC108539701 ARHGEF5 ARHGEF5 DVL2 DVL2 KITLG KITLG TAOK3 TAOK3 EGF EGF PDGFB PDGFB TDGF1 TDGF1 FGFR1 FGFR1 IL1B IL1B NTRK3 NTRK3 ERN1 ERN1 ADAM8 ADAM8 ENSRBIP00000019290 ENSRBIP00000019290
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAP3K10Uncharacterized protein; Belongs to the protein kinase superfamily. (289 aa)
EPHA4EPH receptor A4. (978 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (278 aa)
IL34Interleukin 34. (242 aa)
SASH1SAM and SH3 domain containing 1. (1246 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (767 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (969 aa)
AGERUncharacterized protein. (417 aa)
SYKUncharacterized protein. (331 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
INSRTyrosine-protein kinase receptor. (1372 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (265 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (702 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1565 aa)
EDN1Endothelin 1. (211 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (927 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (972 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
NEK10NIMA related kinase 10. (1144 aa)
CCL19C-C motif chemokine. (98 aa)
AKAP13A-kinase anchoring protein 13. (2816 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
PDE5APhosphodiesterase. (876 aa)
ENSRBIP00000031653Uncharacterized protein. (70 aa)
AJUBAAjuba LIM protein. (538 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MIFUncharacterized protein. (115 aa)
LOC108516810Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (330 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (656 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MST1RMacrophage stimulating 1 receptor. (1417 aa)
ENSRBIP00000034301Ribosomal_S3_C domain-containing protein. (253 aa)
MAGED1MAGE family member D1. (834 aa)
AXIN1Axin 1. (867 aa)
TENM1Teneurin transmembrane protein 1. (1665 aa)
CD40CD40 molecule. (278 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (847 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
LOC108525089END domain-containing protein. (114 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (414 aa)
LOC108524385Uncharacterized protein. (348 aa)
ENSRBIP00000037030Uncharacterized protein. (54 aa)
ENSRBIP00000037360KH type-2 domain-containing protein. (143 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1023 aa)
MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (854 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
TPD52L1TPD52 like 1. (222 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1106 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
THBS1Thrombospondin 1. (1170 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
ENSRBIP00000042593Uncharacterized protein. (229 aa)
ENSRBIP00000043094Uncharacterized protein. (97 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (879 aa)
PDCD10Programmed cell death 10. (212 aa)
SRCTyrosine-protein kinase. (627 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (435 aa)
ENSRBIP00000002430Ribosomal_S3_C domain-containing protein. (168 aa)
ENSRBIP00000002994Protein kinase domain-containing protein. (358 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1153 aa)
ENSRBIP00000004022EGF-like domain-containing protein. (153 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (432 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PLA2G1BPhospholipase A(2). (148 aa)
ENSRBIP00000006958TNF receptor-associated factor. (473 aa)
ROBO1Roundabout guidance receptor 1. (1621 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
CSKTyrosine-protein kinase. (450 aa)
TNFRSF11ATNF receptor superfamily member 11a. (614 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
DUSP19Dual specificity phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (197 aa)
CEACAM1Uncharacterized protein. (525 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
ENSRBIP00000011851Uncharacterized protein. (107 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (890 aa)
LRRK2Protein kinase domain-containing protein. (537 aa)
EPGNEpithelial mitogen. (156 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (90 aa)
DAB2IPDAB2 interacting protein. (1156 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
RASGRP1RAS guanyl releasing protein 1. (841 aa)
TGFATransforming growth factor alpha. (166 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (754 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
LOC108539701Uncharacterized protein. (833 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1579 aa)
DVL2Dishevelled segment polarity protein 2. (735 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (252 aa)
TAOK3TAO kinase 3. (898 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (237 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (187 aa)
FGFR1Fibroblast growth factor receptor. (829 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (980 aa)
ADAM8ADAM metallopeptidase domain 8. (755 aa)
ENSRBIP00000019290KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (242 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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