STRINGSTRING
PRKAG2 PRKAG2 IFNAR1 IFNAR1 NOP53 NOP53 PPP1R3D PPP1R3D PARK7 PARK7 CAVIN3 CAVIN3 INSR INSR AK4 AK4 IDE IDE LOC108535228 LOC108535228 DDIT4 DDIT4 LEXM LEXM RUBCNL RUBCNL FBP1 FBP1 GCK GCK SLC25A33 SLC25A33 HDAC4 HDAC4 OPN3 OPN3 GHITM GHITM PASK PASK ENSRBIP00000020427 ENSRBIP00000020427 PRELID1 PRELID1 ENSRBIP00000018634 ENSRBIP00000018634 TRAP1 TRAP1 EIF6 EIF6 SLC4A1 SLC4A1 ENSRBIP00000018276 ENSRBIP00000018276 PIK3CA PIK3CA ENSRBIP00000017473 ENSRBIP00000017473 ETFBKMT ETFBKMT GCGR GCGR PPARGC1A PPARGC1A IRS2 IRS2 CBFA2T3 CBFA2T3 PHKG2 PHKG2 ZBTB7A ZBTB7A LOC108513918 LOC108513918 SPHK2 SPHK2 GIT1 GIT1 PRKAA1 PRKAA1 ENSRBIP00000025850 ENSRBIP00000025850 PPP1R3F PPP1R3F INPP5K INPP5K ENSRBIP00000026597 ENSRBIP00000026597 LOC108519333 LOC108519333 ZBTB20 ZBTB20 PRDM16 PRDM16 ENSRBIP00000028271 ENSRBIP00000028271 PPP1R3E PPP1R3E TP53 TP53 HTR2A HTR2A IFNLR1 IFNLR1 ENSRBIP00000030482 ENSRBIP00000030482 SORBS1 SORBS1 FAM214B FAM214B JMJD8 JMJD8 ENSRBIP00000031955 ENSRBIP00000031955 APOPT1 APOPT1 ISCU ISCU ENSRBIP00000032659 ENSRBIP00000032659 EP300 EP300 PDE12 PDE12 AKT2 AKT2 ENSRBIP00000034591 ENSRBIP00000034591 NCOR1 NCOR1 GRB10 GRB10 ARL2 ARL2 TRPV4 TRPV4 PPP1R3A PPP1R3A GPD1 GPD1 APP APP PRKAA2 PRKAA2 CISD1 CISD1 IGF2 IGF2 ENSRBIP00000038988 ENSRBIP00000038988 HIF1A HIF1A PNPT1 PNPT1 SHMT2 SHMT2 ARNT ARNT ENPP1 ENPP1 PPP1CA PPP1CA CDK1 CDK1 PHB2 PHB2 ABCD1 ABCD1 PPP1R3C PPP1R3C NUPR1 NUPR1 FLCN FLCN TACO1 TACO1 CCNB1 CCNB1 SLC25A23 SLC25A23 DYRK2 DYRK2 SELENOS SELENOS IRS1 IRS1 ENSRBIP00000012610 ENSRBIP00000012610 ENSRBIP00000012433 ENSRBIP00000012433 SLC2A6 SLC2A6 PPIF PPIF ENSRBIP00000011851 ENSRBIP00000011851 RPTOR RPTOR SIRT6 SIRT6 P2RX7 P2RX7 AKT1 AKT1 ENSRBIP00000010447 ENSRBIP00000010447 PINK1 PINK1 PRKAG1 PRKAG1 ENSRBIP00000009603 ENSRBIP00000009603 IGF1 IGF1 NDUFA4 NDUFA4 STAT3 STAT3 IER3 IER3 TIGAR TIGAR COX7A1 COX7A1 PPARA PPARA AAED1 AAED1 ENSRBIP00000006903 ENSRBIP00000006903 BNIP3 BNIP3 GSK3A GSK3A PGAM1 PGAM1 ENSRBIP00000005902 ENSRBIP00000005902 ACTN3 ACTN3 PTH PTH MTOR MTOR NKX1-1 NKX1-1 PSEN1 PSEN1 MLXIPL MLXIPL MLST8 MLST8 ENSRBIP00000003412 ENSRBIP00000003412 CHCHD2 CHCHD2 NOA1 NOA1 POMC POMC FAM214A FAM214A VCP VCP ENSRBIP00000002132 ENSRBIP00000002132 ENSRBIP00000001933 ENSRBIP00000001933 OGT OGT ENSRBIP00000001313 ENSRBIP00000001313 PPP1R3B PPP1R3B DNAJC15 DNAJC15 OAS1 OAS1 EPM2AIP1 EPM2AIP1 SLC4A4 SLC4A4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (371 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (553 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (478 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit. (294 aa)
PARK7Parkinsonism associated deglycase. (191 aa)
CAVIN3Caveolae associated protein 3. (292 aa)
INSRTyrosine-protein kinase receptor. (1372 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
IDEInsulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
LOC108535228Uncharacterized protein. (115 aa)
DDIT4DNA damage inducible transcript 4. (233 aa)
LEXMLymphocyte expansion molecule. (418 aa)
RUBCNLRubicon like autophagy enhancer. (672 aa)
FBP1Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (293 aa)
GCKPhosphotransferase. (466 aa)
SLC25A33Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1112 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (449 aa)
GHITMGrowth hormone inducible transmembrane protein; Belongs to the BI1 family. (345 aa)
PASKPAS domain containing serine/threonine kinase. (1321 aa)
ENSRBIP00000020427ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (167 aa)
PRELID1PRELI domain containing 1. (219 aa)
ENSRBIP00000018634ZnF_CDGSH domain-containing protein. (114 aa)
TRAP1HATPase_c domain-containing protein. (709 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
SLC4A1Anion exchange protein. (959 aa)
ENSRBIP00000018276Uncharacterized protein. (194 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
ENSRBIP00000017473Uncharacterized protein. (238 aa)
ETFBKMTElectron transfer flavoprotein subunit beta lysine methyltransferase. (262 aa)
GCGRGlucagon receptor; Belongs to the G-protein coupled receptor 2 family. (522 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
IRS2Insulin receptor substrate 2. (904 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (636 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (410 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (386 aa)
LOC108513918Uncharacterized protein. (875 aa)
SPHK2Sphingosine kinase 2. (658 aa)
GIT1GIT ArfGAP 1. (817 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
ENSRBIP00000025850ZnF_CDGSH domain-containing protein. (92 aa)
PPP1R3FProtein phosphatase 1 regulatory subunit 3F. (740 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (456 aa)
ENSRBIP00000026597Uncharacterized protein. (108 aa)
LOC108519333Uncharacterized protein. (205 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
PRDM16PR/SET domain 16. (1173 aa)
ENSRBIP00000028271Uncharacterized protein. (210 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (266 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
HTR2A5-hydroxytryptamine receptor 2A. (472 aa)
IFNLR1Interferon lambda receptor 1. (523 aa)
ENSRBIP00000030482ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (225 aa)
SORBS1Sorbin and SH3 domain containing 1. (1294 aa)
FAM214BFamily with sequence similarity 214 member B. (538 aa)
JMJD8Jumonji domain containing 8. (277 aa)
ENSRBIP00000031955Uncharacterized protein. (75 aa)
APOPT1Uncharacterized protein. (198 aa)
ISCUIron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (167 aa)
ENSRBIP00000032659Uncharacterized protein. (211 aa)
EP300E1A binding protein p300. (2296 aa)
PDE12Phosphodiesterase 12. (609 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSRBIP00000034591Prohibitin. (290 aa)
NCOR1Nuclear receptor corepressor 1. (2441 aa)
GRB10Growth factor receptor bound protein 10. (593 aa)
ARL2ADP ribosylation factor like GTPase 2; Belongs to the small GTPase superfamily. Arf family. (214 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1118 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
APPAmyloid beta precursor protein. (770 aa)
PRKAA2Non-specific serine/threonine protein kinase. (539 aa)
CISD1ZnF_CDGSH domain-containing protein. (108 aa)
IGF2Insulin like growth factor 2. (236 aa)
ENSRBIP00000038988Prohibitin. (157 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (783 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (921 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
PHB2Prohibitin. (299 aa)
ABCD1ATP binding cassette subfamily D member 1. (734 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (100 aa)
FLCNFolliculin. (579 aa)
TACO1Translational activator of cytochrome c oxidase I. (297 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (433 aa)
SLC25A23Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (501 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (595 aa)
SELENOSSelenoprotein S. (210 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
ENSRBIP00000012610Uncharacterized protein. (119 aa)
ENSRBIP00000012433Uncharacterized protein. (53 aa)
SLC2A6Solute carrier family 2 member 6; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (507 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (206 aa)
ENSRBIP00000011851Uncharacterized protein. (107 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1309 aa)
SIRT6Sirtuin 6. (355 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
AKT1AKT serine/threonine kinase 1. (486 aa)
ENSRBIP00000010447Uncharacterized protein. (592 aa)
PINK1PTEN induced kinase 1. (581 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
ENSRBIP00000009603ADK_lid domain-containing protein; Belongs to the adenylate kinase family. (176 aa)
IGF1Insulin like growth factor 1. (208 aa)
NDUFA4NDUFA4 mitochondrial complex associated. (81 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
IER3Immediate early response 3. (156 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (316 aa)
COX7A1Cytochrome c oxidase subunit 7A1. (79 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
AAED1Uncharacterized protein. (213 aa)
ENSRBIP00000006903ZnF_CDGSH domain-containing protein. (107 aa)
BNIP3BCL2 interacting protein 3. (250 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (444 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
ENSRBIP00000005902Uncharacterized protein. (178 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (937 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
NKX1-1Homeobox domain-containing protein. (213 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (432 aa)
MLXIPLMLX interacting protein like. (798 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
ENSRBIP00000003412Uncharacterized protein. (91 aa)
CHCHD2Coiled-coil-helix-coiled-coil-helix domain containing 2. (151 aa)
NOA1Nitric oxide associated 1. (698 aa)
POMCProopiomelanocortin. (251 aa)
FAM214AFamily with sequence similarity 214 member A. (1082 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
ENSRBIP00000002132ZnF_CDGSH domain-containing protein. (108 aa)
ENSRBIP00000001933Uncharacterized protein. (206 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (886 aa)
ENSRBIP00000001313Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (180 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (285 aa)
DNAJC15DnaJ heat shock protein family (Hsp40) member C15. (137 aa)
OAS12'-5'-oligoadenylate synthetase 1. (408 aa)
EPM2AIP1EPM2A interacting protein 1. (607 aa)
SLC4A4Anion exchange protein. (1110 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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