(48 nodes) Negative regulation of T cell differentiation network (Rhinopithecus bieti)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	LAG3	Lymphocyte activating 3. (525 aa)
	ZBTB7B	Zinc finger and BTB domain containing 7B. (539 aa)
	RUNX1	RUNX family transcription factor 1. (264 aa)
	SOCS1	Suppressor of cytokine signaling 1. (215 aa)
	HLX	H2.0 like homeobox. (494 aa)
	RAG2	Recombination activating 2. (527 aa)
	IFNB1	Interferon beta 1. (187 aa)
	TMEM131L	Transmembrane 131 like. (1609 aa)
	ZC3H8	Zinc finger CCCH-type containing 8. (295 aa)
	ENSRBIP00000007280	Tyrosine-protein phosphatase non-receptor type. (354 aa)
	CBFB	Core-binding factor subunit beta. (182 aa)
	IRF1	Interferon regulatory factor. (325 aa)
	ANXA1	Annexin. (346 aa)
	ENSRBIP00000009622	Uncharacterized protein. (329 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	LOC108518721	Ig-like domain-containing protein. (407 aa)
	LOC108527168	Uncharacterized protein. (200 aa)
	CLEC4G	C-type lectin domain family 4 member G. (293 aa)
	IL4R	Interleukin 4 receptor. (825 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1165 aa)
	CDKN2A	Uncharacterized protein. (173 aa)
	MDK	Uncharacterized protein. (143 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	FOXP3	Forkhead box P3. (456 aa)
	FGL2	Fibrinogen like 2. (439 aa)
	LOXL3	Lysyl oxidase like 3. (756 aa)
	ENSRBIP00000021702	Uncharacterized protein. (144 aa)
	TNFSF18	TNF superfamily member 18. (199 aa)
	JAK3	Tyrosine-protein kinase. (1124 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1134 aa)
	GLI3	GLI family zinc finger 3. (1555 aa)
	SMAD7	Mothers against decapentaplegic homolog. (431 aa)
	LOC108530904	Uncharacterized protein. (648 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (387 aa)
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (223 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	ENSRBIP00000032286	Uncharacterized protein. (185 aa)
	ENSRBIP00000033881	Uncharacterized protein. (61 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
	RUNX3	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (570 aa)
	CD74	CD74 molecule. (294 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	TBX21	T-box transcription factor 21. (524 aa)
	FOXJ1	Forkhead box J1. (421 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	CTLA4	ENSRBIP00000036911	ENSRBIP00000031397	BCL6 transcription repressor.	Cytotoxic T-lymphocyte associated protein 4.	0.472
BCL6	FOXP3	ENSRBIP00000036911	ENSRBIP00000019889	BCL6 transcription repressor.	Forkhead box P3.	0.637
BCL6	TBX21	ENSRBIP00000036911	ENSRBIP00000040398	BCL6 transcription repressor.	T-box transcription factor 21.	0.598
BMP4	CBFB	ENSRBIP00000039189	ENSRBIP00000008602	Bone morphogenetic protein 4.	Core-binding factor subunit beta.	0.430
BMP4	RAG2	ENSRBIP00000039189	ENSRBIP00000004273	Bone morphogenetic protein 4.	Recombination activating 2.	0.401
BMP4	RUNX1	ENSRBIP00000039189	ENSRBIP00000001162	Bone morphogenetic protein 4.	RUNX family transcription factor 1.	0.451
BMP4	RUNX3	ENSRBIP00000039189	ENSRBIP00000035040	Bone morphogenetic protein 4.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.448
BMP4	SHH	ENSRBIP00000039189	ENSRBIP00000011175	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.595
BMP4	SMAD7	ENSRBIP00000039189	ENSRBIP00000028055	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.566
CBFB	BMP4	ENSRBIP00000008602	ENSRBIP00000039189	Core-binding factor subunit beta.	Bone morphogenetic protein 4.	0.430
CBFB	FOXP3	ENSRBIP00000008602	ENSRBIP00000019889	Core-binding factor subunit beta.	Forkhead box P3.	0.685
CBFB	IHH	ENSRBIP00000008602	ENSRBIP00000034718	Core-binding factor subunit beta.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.422
CBFB	RUNX1	ENSRBIP00000008602	ENSRBIP00000001162	Core-binding factor subunit beta.	RUNX family transcription factor 1.	0.988
CBFB	RUNX3	ENSRBIP00000008602	ENSRBIP00000035040	Core-binding factor subunit beta.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.968
CLEC4G	LAG3	ENSRBIP00000013794	ENSRBIP00000021097	C-type lectin domain family 4 member G.	Lymphocyte activating 3.	0.713
CTLA4	BCL6	ENSRBIP00000031397	ENSRBIP00000036911	Cytotoxic T-lymphocyte associated protein 4.	BCL6 transcription repressor.	0.472
CTLA4	FOXP3	ENSRBIP00000031397	ENSRBIP00000019889	Cytotoxic T-lymphocyte associated protein 4.	Forkhead box P3.	0.656
CTLA4	IL2	ENSRBIP00000031397	ENSRBIP00000038475	Cytotoxic T-lymphocyte associated protein 4.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.604
CTLA4	JAK3	ENSRBIP00000031397	ENSRBIP00000027720	Cytotoxic T-lymphocyte associated protein 4.	Tyrosine-protein kinase.	0.522
CTLA4	LAG3	ENSRBIP00000031397	ENSRBIP00000021097	Cytotoxic T-lymphocyte associated protein 4.	Lymphocyte activating 3.	0.658