STRINGSTRING
PPP3CA-2 PPP3CA-2 ENSRBIP00000000203 ENSRBIP00000000203 CCR1 CCR1 RUNX1 RUNX1 ENSRBIP00000001234 ENSRBIP00000001234 PPP3CA PPP3CA CTNNBIP1 CTNNBIP1 LIF LIF HCLS1 HCLS1 MTURN MTURN ETS1 ETS1 FAXDC2 FAXDC2 GATA1 GATA1 NINJ1 NINJ1 TGFB1 TGFB1 GPR68 GPR68 ENSRBIP00000006958 ENSRBIP00000006958 SMAP1 SMAP1 STAT3 STAT3 LEF1 LEF1 FAM210B FAM210B JAG1 JAG1 IL23R IL23R ENSRBIP00000013298 ENSRBIP00000013298 PRKDC PRKDC POU4F2 POU4F2 HAX1 HAX1 KAT7 KAT7 MED1 MED1 NEDD9 NEDD9 TESC TESC CSF3 CSF3 ACIN1 ACIN1 KITLG KITLG ABCB10 ABCB10 STAT5B STAT5B NCKAP1L NCKAP1L CSF1 CSF1 POU4F1 POU4F1 RB1 RB1 INPP5D INPP5D TMEM64 TMEM64 PRKCA PRKCA ANKRD54 ANKRD54 INHBA INHBA IL34 IL34 CD101 CD101 FES FES PITHD1 PITHD1 DCSTAMP DCSTAMP PF4 PF4 IL23A IL23A BRD1 BRD1 FOS FOS HOXA5 HOXA5 TNFSF11 TNFSF11 PPARGC1B PPARGC1B TAL1 TAL1 FADD FADD TRIB1 TRIB1 ACVR1B ACVR1B MPL MPL PRMT1 PRMT1 ROR2 ROR2 TREM2 TREM2 MAPK14 MAPK14 RHEX RHEX ZNF16 ZNF16 RCOR1 RCOR1 GATA2 GATA2 ISG15 ISG15 CD4 CD4 IFNG IFNG PLA2G3 PLA2G3 KLF10 KLF10 CALCA CALCA ZFP36L1 ZFP36L1 CREB1 CREB1 SCIN SCIN NOTCH2 NOTCH2 TRAF6 TRAF6 STAT1 STAT1 THPO THPO SLC9B2 SLC9B2 CD74 CD74 OCSTAMP OCSTAMP IL20 IL20 ACVR2A ACVR2A HIF1A HIF1A RAB7B RAB7B ARNT ARNT RIPK1 RIPK1 LOC108541626 LOC108541626 IL17A IL17A HSF1 HSF1 ENSRBIP00000042195 ENSRBIP00000042195 CASP8 CASP8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP3CA-2Uncharacterized protein. (70 aa)
ENSRBIP00000000203Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (250 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
RUNX1RUNX family transcription factor 1. (264 aa)
ENSRBIP00000001234Uncharacterized protein. (93 aa)
PPP3CASerine/threonine-protein phosphatase. (310 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (476 aa)
MTURNMaturin, neural progenitor differentiation regulator homolog. (131 aa)
ETS1ETS proto-oncogene 1, transcription factor. (485 aa)
FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (333 aa)
GATA1GATA binding protein 1. (421 aa)
NINJ1Ninjurin 1. (152 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
ENSRBIP00000006958TNF receptor-associated factor. (473 aa)
SMAP1Small ArfGAP 1. (307 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LEF1Lymphoid enhancer binding factor 1. (398 aa)
FAM210BFamily with sequence similarity 210 member B. (176 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
IL23RInterleukin 23 receptor. (629 aa)
ENSRBIP00000013298HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (200 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
POU4F2POU domain protein. (408 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (606 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1547 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (839 aa)
TESCTescalcin. (214 aa)
CSF3Colony stimulating factor 3. (204 aa)
ACIN1Apoptotic chromatin condensation inducer 1. (1334 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (252 aa)
ABCB10ATP binding cassette subfamily B member 10. (738 aa)
STAT5BSignal transducer and activator of transcription. (768 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
CSF1Colony stimulating factor 1. (587 aa)
POU4F1POU domain protein. (424 aa)
RB1RB transcriptional corepressor 1. (815 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1194 aa)
TMEM64Transmembrane protein 64. (360 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
ANKRD54Ankyrin repeat domain 54. (276 aa)
INHBAInhibin subunit beta A. (426 aa)
IL34Interleukin 34. (242 aa)
CD101CD101 molecule. (1021 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
PITHD1PITH domain containing 1. (212 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
PF4C-X-C motif chemokine. (101 aa)
IL23AInterleukin 23 subunit alpha. (189 aa)
BRD1Bromodomain containing 1. (1094 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
HOXA5Homeobox A5. (270 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
PPARGC1BPPARG coactivator 1 beta. (1024 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (325 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (635 aa)
PRMT1Methyltransf_25 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (927 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (231 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
RHEXRegulator of hemoglobinization and erythroid cell expansion. (178 aa)
ZNF16Zinc finger protein 16. (682 aa)
RCOR1REST corepressor 1. (397 aa)
GATA2GATA binding protein 2. (468 aa)
ISG15ISG15 ubiquitin like modifier. (167 aa)
CD4CD4 molecule. (458 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
PLA2G3Phospholipase A2 group III. (508 aa)
KLF10Kruppel like factor 10. (480 aa)
CALCACalcitonin related polypeptide alpha. (144 aa)
ZFP36L1Uncharacterized protein. (327 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
SCINScinderin. (715 aa)
NOTCH2Notch receptor 2. (2532 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
STAT1Signal transducer and activator of transcription. (787 aa)
THPOThrombopoietin. (353 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
CD74CD74 molecule. (294 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (536 aa)
IL20Interleukin 20. (176 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
RAB7BRAB7B, member RAS oncogene family. (199 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (672 aa)
LOC108541626Uncharacterized protein. (246 aa)
IL17AInterleukin 17A. (155 aa)
HSF1Heat shock transcription factor 1. (489 aa)
ENSRBIP00000042195Uncharacterized protein. (122 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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