(45 nodes) Autonomic nervous system development network (Rhinopithecus bieti)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLX2	T cell leukemia homeobox 2. (284 aa)
	NF1	Neurofibromin 1. (2822 aa)
	NTRK1	Tyrosine-protein kinase receptor. (816 aa)
	TBX1	T-box transcription factor 1. (371 aa)
	SEMA3A	Semaphorin 3A; Belongs to the semaphorin family. (774 aa)
	HOXB1	Homeobox B1. (304 aa)
	TFAP2B	Transcription factor AP-2 beta. (442 aa)
	FZD3	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
	SOX8	SRY-box transcription factor 8. (429 aa)
	ISX	Intestine specific homeobox. (233 aa)
	PRLH	Prolactin releasing hormone. (87 aa)
	ARX	Aristaless related homeobox. (512 aa)
	GFRA3	GDNF family receptor alpha 3. (402 aa)
	SEMA3F	Semaphorin 3F; Belongs to the semaphorin family. (785 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1099 aa)
	PLXNA4	Plexin A4. (1894 aa)
	PHOX2A	Paired like homeobox 2A. (283 aa)
	KIF26A	Kinesin family member 26A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2062 aa)
	RHOXF1	Homeobox domain-containing protein. (185 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (930 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	NAV2	Neuron navigator 2. (2452 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	PLXNA3	Plexin A3. (1876 aa)
	EDNRB	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (507 aa)
	NTF3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (278 aa)
	GBX2	Gastrulation brain homeobox 2. (348 aa)
	VCAM1	Vascular cell adhesion molecule 1. (739 aa)
	ADARB1	Adenosine deaminase RNA specific B1. (783 aa)
	SOX10	SRY-box transcription factor 10. (466 aa)
	EGR2	Early growth response 2. (542 aa)
	TFAP2A	Transcription factor AP-2 alpha. (465 aa)
	PHOX2B	Paired like homeobox 2B. (284 aa)
	GATA3	GATA binding protein 3. (444 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (426 aa)
	GDNF	Glial cell derived neurotrophic factor. (228 aa)
	ACKR3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (234 aa)
	HOXB2	Homeobox B2. (356 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	PHACTR4	Phosphatase and actin regulator. (712 aa)
	HLX	H2.0 like homeobox. (494 aa)
	SOX4	Transcription factor SOX. (475 aa)
	FN1	Fibronectin 1. (2477 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARX	TLX2	ENSRBIP00000030286	ENSRBIP00000023371	Aristaless related homeobox.	T cell leukemia homeobox 2.	0.526
ASCL1	PHOX2B	ENSRBIP00000010802	ENSRBIP00000014433	Achaete-scute family bHLH transcription factor 1.	Paired like homeobox 2B.	0.569
CTNNB1	FZD3	ENSRBIP00000022705	ENSRBIP00000033158	Catenin beta 1.	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	0.551
CTNNB1	NTRK1	ENSRBIP00000022705	ENSRBIP00000039867	Catenin beta 1.	Tyrosine-protein kinase receptor.	0.441
CTNNB1	SOX10	ENSRBIP00000022705	ENSRBIP00000015856	Catenin beta 1.	SRY-box transcription factor 10.	0.636
CTNNB1	SOX4	ENSRBIP00000022705	ENSRBIP00000001855	Catenin beta 1.	Transcription factor SOX.	0.731
CTNNB1	SOX8	ENSRBIP00000022705	ENSRBIP00000032516	Catenin beta 1.	SRY-box transcription factor 8.	0.569
EDNRA	EDNRB	ENSRBIP00000012534	ENSRBIP00000021214	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	0.975
EDNRB	EDNRA	ENSRBIP00000021214	ENSRBIP00000012534	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.975
EDNRB	RET	ENSRBIP00000021214	ENSRBIP00000028216	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.558
EDNRB	SOX10	ENSRBIP00000021214	ENSRBIP00000015856	Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.	SRY-box transcription factor 10.	0.565
EGR2	GATA3	ENSRBIP00000015222	ENSRBIP00000013825	Early growth response 2.	GATA binding protein 3.	0.561
EGR2	SOX10	ENSRBIP00000015222	ENSRBIP00000015856	Early growth response 2.	SRY-box transcription factor 10.	0.812
EGR2	SOX8	ENSRBIP00000015222	ENSRBIP00000032516	Early growth response 2.	SRY-box transcription factor 8.	0.538
FZD3	CTNNB1	ENSRBIP00000033158	ENSRBIP00000022705	Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family.	Catenin beta 1.	0.551
GATA3	EGR2	ENSRBIP00000013825	ENSRBIP00000015222	GATA binding protein 3.	Early growth response 2.	0.561
GATA3	HAND2	ENSRBIP00000013825	ENSRBIP00000009351	GATA binding protein 3.	Heart and neural crest derivatives expressed 2.	0.602
GATA3	PHOX2B	ENSRBIP00000013825	ENSRBIP00000014433	GATA binding protein 3.	Paired like homeobox 2B.	0.556
GDNF	GFRA3	ENSRBIP00000012487	ENSRBIP00000029693	Glial cell derived neurotrophic factor.	GDNF family receptor alpha 3.	0.910
GDNF	NTF3	ENSRBIP00000012487	ENSRBIP00000020766	Glial cell derived neurotrophic factor.	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.	0.559