STRINGSTRING
PLAA PLAA ERBB4 ERBB4 PIM1 PIM1 CSF1 CSF1 SEMA7A SEMA7A TBX5 TBX5 NRP1 NRP1 TGFBR2 TGFBR2 EFNA5 EFNA5 INSR INSR ENSRBIP00000024675 ENSRBIP00000024675 YAP1 YAP1 L1CAM L1CAM SASH3 SASH3 EZR EZR CRABP2 CRABP2 EDN1 EDN1 ENSRBIP00000027119 ENSRBIP00000027119 AGR2 AGR2 IL7 IL7 MAPK14 MAPK14 SMAD7 SMAD7 BBS4 BBS4 AKAP6 AKAP6 AGRN AGRN FGF8 FGF8 NTN1 NTN1 GHRL GHRL CPNE5 CPNE5 FGF9 FGF9 ARX ARX LOC108515307 LOC108515307 WT1 WT1 NRG1 NRG1 YBX3 YBX3 WNT3A WNT3A BBS2 BBS2 TGFBR3 TGFBR3 CDH4 CDH4 TSHR TSHR CXCL12 CXCL12 MEF2C MEF2C DISC1 DISC1 CREB1 CREB1 PROX1 PROX1 GLI1 GLI1 ANAPC2 ANAPC2 ENSRBIP00000035669 ENSRBIP00000035669 PPARD PPARD ACACB ACACB MAPT MAPT SHTN1 SHTN1 NOL12 NOL12 RNF157 RNF157 SYT3 SYT3 RND2 RND2 IGF2 IGF2 GHRH GHRH SYT2 SYT2 PARP2 PARP2 CHD7 CHD7 NGF NGF LEP LEP MUL1 MUL1 PLS1 PLS1 SPTBN4 SPTBN4 SMO SMO VIL1 VIL1 WNT2 WNT2 GHR GHR NIPBL NIPBL GOLGA4 GOLGA4 RIMS2 RIMS2 UNC13A UNC13A ITSN2 ITSN2 ENSRBIP00000019241 ENSRBIP00000019241 PPIB PPIB ACTN3 ACTN3 SOX15 SOX15 ENSRBIP00000006170 ENSRBIP00000006170 CAPN3 CAPN3 TWF2 TWF2 PLCB1 PLCB1 SYT1 SYT1 CACNG7 CACNG7 ADNP ADNP MKKS MKKS SRF SRF ENSRBIP00000000587 ENSRBIP00000000587 BASP1 BASP1 RUFY3 RUFY3 FN1 FN1 GPAM GPAM WNT3 WNT3 DBN1 DBN1 HLX HLX SYT17 SYT17 BCL11A BCL11A TRPC5 TRPC5 RAG2 RAG2 DLL1 DLL1 SMURF1 SMURF1 LOC108525471 LOC108525471 NOTCH1 NOTCH1 TBX2 TBX2 HEY2 HEY2 SEMA4D SEMA4D DBNL DBNL RIMS1 RIMS1 GHRHR GHRHR ENSRBIP00000020193 ENSRBIP00000020193 SEMA5A SEMA5A PRKN PRKN SLC23A2 SLC23A2 DRD2 DRD2 BDNF BDNF IGF1 IGF1 HOPX HOPX GHSR GHSR LIMK1 LIMK1 CYFIP1 CYFIP1 AKT1 AKT1 BCL2 BCL2 RASAL1 RASAL1 SYT4 SYT4 LPAR3 LPAR3 BMP10 BMP10 BMPR2 BMPR2 MEGF8 MEGF8 POU4F2 POU4F2 MAP1B MAP1B MAP3K13 MAP3K13 DSCAM DSCAM CPNE9 CPNE9 FGFR2 FGFR2 ZFYVE27 ZFYVE27 MYOD1 MYOD1 BMPR1A BMPR1A SLC6A3 SLC6A3 PEX5 PEX5 ZFPM2 ZFPM2 TBX20 TBX20 RPS6KB1 RPS6KB1 STAT5B STAT5B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLAAPhospholipase A2 activating protein. (795 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PIM1Pim-1 proto-oncogene, serine/threonine kinase. (534 aa)
CSF1Colony stimulating factor 1. (587 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (668 aa)
TBX5T-box transcription factor 5. (518 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
INSRTyrosine-protein kinase receptor. (1372 aa)
ENSRBIP00000024675Uncharacterized protein. (178 aa)
YAP1Yes associated protein 1. (326 aa)
L1CAML1 cell adhesion molecule. (1257 aa)
SASH3SAM and SH3 domain containing 3. (357 aa)
EZREzrin. (588 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
EDN1Endothelin 1. (211 aa)
ENSRBIP00000027119Calponin-homology (CH) domain-containing protein. (910 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (171 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
BBS4Bardet-Biedl syndrome 4. (347 aa)
AKAP6A-kinase anchoring protein 6. (2307 aa)
AGRNAgrin. (2020 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
NTN1Netrin 1. (604 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
CPNE5Copine 5. (610 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ARXAristaless related homeobox. (512 aa)
LOC108515307Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (526 aa)
WT1WT1 transcription factor. (515 aa)
NRG1Neuregulin 1. (713 aa)
YBX3Y-box binding protein 3. (371 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (717 aa)
TGFBR3Transforming growth factor beta receptor 3. (861 aa)
CDH4Cadherin 4. (752 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
DISC1Uncharacterized protein. (379 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PROX1Prospero homeobox 1. (737 aa)
GLI1GLI family zinc finger 1. (1106 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (822 aa)
ENSRBIP00000035669Uncharacterized protein. (663 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
ACACBAcetyl-CoA carboxylase beta. (2458 aa)
MAPTMicrotubule-associated protein. (776 aa)
SHTN1Shootin 1. (631 aa)
NOL12Uncharacterized protein. (213 aa)
RNF157Ring finger protein 157. (669 aa)
SYT3Synaptotagmin 3. (590 aa)
RND2Rho family GTPase 2. (170 aa)
IGF2Insulin like growth factor 2. (236 aa)
GHRHGrowth hormone releasing hormone. (107 aa)
SYT2Synaptotagmin 2. (419 aa)
PARP2Poly [ADP-ribose] polymerase. (570 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2986 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (352 aa)
PLS1Plastin 1. (629 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2534 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
VIL1Villin 1. (827 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
GHRGrowth hormone receptor. (606 aa)
NIPBLNipped-B protein. (2777 aa)
GOLGA4Golgin A4. (2283 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1524 aa)
UNC13AUnc-13 homolog A. (1704 aa)
ITSN2Intersectin 2. (1669 aa)
ENSRBIP00000019241Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (458 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (937 aa)
SOX15SRY-box transcription factor 15. (232 aa)
ENSRBIP00000006170Uncharacterized protein. (121 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (826 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
SYT1Synaptotagmin 1. (283 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
ADNPActivity dependent neuroprotector homeobox. (1101 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
SRFSerum response factor. (508 aa)
ENSRBIP00000000587Uncharacterized protein. (81 aa)
BASP1Brain abundant membrane attached signal protein 1. (186 aa)
RUFY3RUN and FYVE domain containing 3. (588 aa)
FN1Fibronectin 1. (2477 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
DBN1Drebrin 1. (688 aa)
HLXH2.0 like homeobox. (494 aa)
SYT17Synaptotagmin 17. (505 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (805 aa)
TRPC5Transient receptor potential cation channel subfamily C member 5; Belongs to the transient receptor (TC 1.A.4) family. (959 aa)
RAG2Recombination activating 2. (527 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (748 aa)
SMURF1SMAD specific E3 ubiquitin protein ligase 1. (704 aa)
LOC108525471Uncharacterized protein. (356 aa)
NOTCH1Notch receptor 1. (2438 aa)
TBX2T-box transcription factor 2. (686 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
DBNLDrebrin like. (432 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1693 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
ENSRBIP00000020193Uncharacterized protein. (326 aa)
SEMA5ASemaphorin 5A. (1035 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
SLC23A2Solute carrier family 23 member 2. (650 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
IGF1Insulin like growth factor 1. (208 aa)
HOPXHOP homeobox. (109 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
LIMK1LIM domain kinase 1. (677 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
AKT1AKT serine/threonine kinase 1. (486 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
RASAL1RAS protein activator like 1. (676 aa)
SYT4Synaptotagmin 4. (424 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (341 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
MEGF8Multiple EGF like domains 8. (2767 aa)
POU4F2POU domain protein. (408 aa)
MAP1BMicrotubule associated protein 1B. (2276 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
DSCAMDS cell adhesion molecule. (1775 aa)
CPNE9Copine family member 9. (474 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (416 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (620 aa)
PEX5Peroxisomal biogenesis factor 5. (639 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1257 aa)
TBX20T-box transcription factor 20. (447 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (490 aa)
STAT5BSignal transducer and activator of transcription. (768 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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