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FGF10 FGF10 ENSRBIP00000019241 ENSRBIP00000019241 LOC108522656 LOC108522656 MESP1 MESP1 BMPR1A BMPR1A FGFR2 FGFR2 LEMD2 LEMD2 SHH SHH LRP2 LRP2 HOXA3 HOXA3 TP63 TP63 RBM20 RBM20 ISL1 ISL1 PAX2 PAX2 NTF4 NTF4 NOG NOG SELENOH SELENOH NKX3-2 NKX3-2 CTNNB1 CTNNB1 RDH10 RDH10 MAPK3 MAPK3 EMP2 EMP2 WNT5A WNT5A BMP4 BMP4 WNT11 WNT11 EXT1 EXT1 MEF2C MEF2C SOX17 SOX17 FOLR1 FOLR1 SMARCD3 SMARCD3 FOXH1 FOXH1 AXIN2 AXIN2 GLI3 GLI3 MAPK1 MAPK1 TBR1 TBR1 TGFBR2 TGFBR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSRBIP00000019241Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (458 aa)
LOC108522656NR LBD domain-containing protein. (344 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (272 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
LEMD2LEM domain containing 2. (437 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
LRP2LDL receptor related protein 2. (4655 aa)
HOXA3Homeobox A3. (434 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
RBM20RNA binding motif protein 20. (1191 aa)
ISL1ISL LIM homeobox 1. (349 aa)
PAX2Paired box 2. (242 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (231 aa)
SELENOHSelenoprotein H. (121 aa)
NKX3-2NK3 homeobox 2. (333 aa)
CTNNB1Catenin beta 1. (781 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SOX17SRY-box transcription factor 17. (412 aa)
FOLR1Folate receptor alpha. (257 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (501 aa)
FOXH1Forkhead box H1. (366 aa)
AXIN2Axin 2. (843 aa)
GLI3GLI family zinc finger 3. (1555 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
TBR1T-box brain transcription factor 1. (682 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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