(41 nodes) Embryonic cranial skeleton morphogenesis network (Rhinopithecus bieti)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	NODAL	Nodal growth differentiation factor. (347 aa)
	NDST1	N-deacetylase and N-sulfotransferase 1. (883 aa)
	PAX5	Paired box 5. (391 aa)
	CHST11	Carbohydrate sulfotransferase. (352 aa)
	TBX15	T-box transcription factor 15. (602 aa)
	EIF4A3	Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (412 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	TFAP2A	Transcription factor AP-2 alpha. (465 aa)
	FGFR2	Fibroblast growth factor receptor. (840 aa)
	WDR19	WD repeat domain 19. (1307 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	ALX3	ALX homeobox 3. (343 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	IRX5	Iroquois homeobox 5. (483 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	GLI3	GLI family zinc finger 3. (1555 aa)
	HOXA1	Homeobox A1. (334 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	DLX2	Distal-less homeobox 2. (328 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2563 aa)
	MED12	Mediator complex subunit 12. (2055 aa)
	IFT140	Intraflagellar transport 140. (1460 aa)
	SIX4	SIX homeobox 4. (780 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
	SMAD3	Mothers against decapentaplegic homolog. (480 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	SIX2	SIX homeobox 2. (292 aa)
	PRRX1	Paired related homeobox 1. (245 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (965 aa)
	TBX1	T-box transcription factor 1. (371 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	SIX1	SIX homeobox 1. (284 aa)
	LOC108541626	Uncharacterized protein. (246 aa)
	NIPBL	Nipped-B protein. (2777 aa)
	GRHL2	Grainyhead like transcription factor 2. (625 aa)
	TULP3	TUB like protein 3; Belongs to the TUB family. (482 aa)
	HOXA2	Homeobox A2. (374 aa)
	SLC39A1	Solute carrier family 39 member 1. (324 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	RUNX2	RUNX family transcription factor 2. (610 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	DLX2	ENSRBIP00000039189	ENSRBIP00000028919	Bone morphogenetic protein 4.	Distal-less homeobox 2.	0.420
BMP4	FGF8	ENSRBIP00000039189	ENSRBIP00000028522	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.549
BMP4	RUNX2	ENSRBIP00000039189	ENSRBIP00000007542	Bone morphogenetic protein 4.	RUNX family transcription factor 2.	0.592
BMP4	SMAD2	ENSRBIP00000039189	ENSRBIP00000012165	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.620
BMP4	SMAD3	ENSRBIP00000039189	ENSRBIP00000006520	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.552
BMP4	TGFBR1	ENSRBIP00000039189	ENSRBIP00000034156	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.695
BMP4	TGFBR2	ENSRBIP00000039189	ENSRBIP00000023211	Bone morphogenetic protein 4.	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.491
DLX2	BMP4	ENSRBIP00000028919	ENSRBIP00000039189	Distal-less homeobox 2.	Bone morphogenetic protein 4.	0.420
DLX2	FGF8	ENSRBIP00000028919	ENSRBIP00000028522	Distal-less homeobox 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.400
DLX2	IRX5	ENSRBIP00000028919	ENSRBIP00000027070	Distal-less homeobox 2.	Iroquois homeobox 5.	0.464
DLX2	RUNX2	ENSRBIP00000028919	ENSRBIP00000007542	Distal-less homeobox 2.	RUNX family transcription factor 2.	0.406
FGF8	BMP4	ENSRBIP00000028522	ENSRBIP00000039189	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.549
FGF8	DLX2	ENSRBIP00000028522	ENSRBIP00000028919	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Distal-less homeobox 2.	0.400
FGF8	FGFR2	ENSRBIP00000028522	ENSRBIP00000014788	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.994
FGF8	GLI3	ENSRBIP00000028522	ENSRBIP00000027791	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GLI family zinc finger 3.	0.456
FGFR2	FGF8	ENSRBIP00000014788	ENSRBIP00000028522	Fibroblast growth factor receptor.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.994
FGFR2	RUNX2	ENSRBIP00000014788	ENSRBIP00000007542	Fibroblast growth factor receptor.	RUNX family transcription factor 2.	0.443
GLI3	FGF8	ENSRBIP00000027791	ENSRBIP00000028522	GLI family zinc finger 3.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.456
GLI3	MED12	ENSRBIP00000027791	ENSRBIP00000031058	GLI family zinc finger 3.	Mediator complex subunit 12.	0.417
IFT140	TULP3	ENSRBIP00000033118	ENSRBIP00000004679	Intraflagellar transport 140.	TUB like protein 3; Belongs to the TUB family.	0.814