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LRP1 LRP1 SRF SRF COMP COMP HOXA13 HOXA13 HPGD HPGD SOX4 SOX4 TGFB2 TGFB2 NOG NOG EYA1 EYA1 GJA5 GJA5 HEY1 HEY1 COL3A1 COL3A1 HAND2 HAND2 ACVRL1 ACVRL1 PRDM1 PRDM1 ENSRBIP00000010821 ENSRBIP00000010821 LRP2 LRP2 APOB APOB CITED2 CITED2 ZMIZ1 ZMIZ1 JAG1 JAG1 EDNRA EDNRA BMPR2 BMPR2 PDGFRB PDGFRB BMPR1A BMPR1A LOC108520322 LOC108520322 DLL4 DLL4 LDLR LDLR ENSRBIP00000019241 ENSRBIP00000019241 ANGPTL3 ANGPTL3 EFEMP2 EFEMP2 APOE APOE HEY2 HEY2 TBX2 TBX2 NOTCH1 NOTCH1 NRP1 NRP1 MYLK MYLK FKBP10 FKBP10 MYOCD MYOCD STRA6 STRA6 EDN1 EDN1 NPRL3 NPRL3 SMAD7 SMAD7 HOXA1 HOXA1 FGF8 FGF8 SEC24B SEC24B FOXH1 FOXH1 FOLR1 FOLR1 TFAP2B TFAP2B ADGRF5 ADGRF5 PROX1 PROX1 TGFBR1 TGFBR1 ENG ENG ADAMTS9 ADAMTS9 ARID2 ARID2 PRRX1 PRRX1 WNT11 WNT11 TBX1 TBX1 BMP4 BMP4 CHD7 CHD7 NOTCH3 NOTCH3 PKD2 PKD2 FOXF1 FOXF1 NF1 NF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRP1LDL receptor related protein 1. (4461 aa)
SRFSerum response factor. (508 aa)
COMPCartilage oligomeric matrix protein. (649 aa)
HOXA13Homeobox domain-containing protein. (214 aa)
HPGD15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (266 aa)
SOX4Transcription factor SOX. (475 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (231 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
COL3A1Collagen type III alpha 1 chain. (1333 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PRDM1PR/SET domain 1. (825 aa)
ENSRBIP00000010821Uncharacterized protein. (441 aa)
LRP2LDL receptor related protein 2. (4655 aa)
APOBApolipoprotein B. (4513 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (253 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1073 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (426 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1102 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LOC108520322Fork-head domain-containing protein. (198 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
LDLRLow density lipoprotein receptor. (819 aa)
ENSRBIP00000019241Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (458 aa)
ANGPTL3Angiopoietin like 3. (446 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
APOEApolipoprotein E. (317 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
TBX2T-box transcription factor 2. (686 aa)
NOTCH1Notch receptor 1. (2438 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
MYLKMyosin light chain kinase. (1656 aa)
FKBP10Peptidylprolyl isomerase. (582 aa)
MYOCDMyocardin. (832 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
EDN1Endothelin 1. (211 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (562 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
HOXA1Homeobox A1. (334 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1252 aa)
FOXH1Forkhead box H1. (366 aa)
FOLR1Folate receptor alpha. (257 aa)
TFAP2BTranscription factor AP-2 beta. (442 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1343 aa)
PROX1Prospero homeobox 1. (737 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
ENGEndoglin. (607 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1916 aa)
ARID2AT-rich interaction domain 2. (1830 aa)
PRRX1Paired related homeobox 1. (245 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
TBX1T-box transcription factor 1. (371 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2986 aa)
NOTCH3Notch receptor 3. (2331 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (958 aa)
FOXF1Forkhead box F1. (380 aa)
NF1Neurofibromin 1. (2822 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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