STRINGSTRING
HLX HLX BMP2 BMP2 HYAL1 HYAL1 NF1 NF1 BTK BTK PKHD1 PKHD1 BAD BAD WNT2 WNT2 HTR2B HTR2B SMO SMO TNFSF12 TNFSF12 IL10 IL10 WNT5A WNT5A ARNT ARNT WNT7A WNT7A VASH2 VASH2 NRAS NRAS BMP4 BMP4 HIF1A HIF1A MTA3 MTA3 IGF2 IGF2 PLCG1 PLCG1 TBX1 TBX1 MAP2K5 MAP2K5 AGAP2 AGAP2 KDM5B KDM5B HMX2 HMX2 EGFR EGFR MST1 MST1 RREB1 RREB1 CCL26 CCL26 SCG2 SCG2 FLT4 FLT4 AGGF1 AGGF1 MYDGF MYDGF NOTCH2 NOTCH2 ZNF304 ZNF304 SP1 SP1 AGTR1 AGTR1 SRSF6 SRSF6 ODAM ODAM TGM1 TGM1 VEGFA VEGFA AREG AREG CRNN CRNN NKX2-6 NKX2-6 PIK3CD PIK3CD LRG1 LRG1 CLDN1 CLDN1 IHH IHH AKT3 AKT3 TGFBR1 TGFBR1 PROX1 PROX1 ENSRBIP00000033881 ENSRBIP00000033881 ITGA4 ITGA4 PTN PTN MYC MYC CXCL12 CXCL12 WNT3A WNT3A ERBB2 ERBB2 CCL24 CCL24 PDX1 PDX1 FGF2 FGF2 LAMC1 LAMC1 LACRT LACRT FGF9 FGF9 GATA2 GATA2 VIP VIP ID1 ID1 OSR1 OSR1 GHRL GHRL APELA APELA NODAL NODAL TEK TEK ARG1 ARG1 ENSRBIP00000027339 ENSRBIP00000027339 IL18 IL18 BMP5 BMP5 FGF7 FGF7 HTRA1 HTRA1 GDF2 GDF2 TACR1 TACR1 CCND1 CCND1 YAP1 YAP1 NR4A1 NR4A1 JCAD JCAD PROK1 PROK1 NR4A3 NR4A3 IQGAP3 IQGAP3 ZBED9 ZBED9 NRP2 NRP2 CTNNB1 CTNNB1 REG3A REG3A NRP1 NRP1 LOC108525471 LOC108525471 NOTCH1 NOTCH1 VEGFB VEGFB HRAS HRAS ENSRBIP00000021702 ENSRBIP00000021702 XBP1 XBP1 GRN GRN PRKCA PRKCA ZNF703 ZNF703 TNFAIP3 TNFAIP3 SPINK1 SPINK1 SEMA5A SEMA5A RTN4 RTN4 EMC10 EMC10 MDK MDK ENSRBIP00000019241 ENSRBIP00000019241 LOC108522656 LOC108522656 WDR48 WDR48 FGFR1 FGFR1 PDGFB PDGFB ST8SIA1 ST8SIA1 SFRP1 SFRP1 IRS2 IRS2 MMP12 MMP12 EGF EGF CCR3 CCR3 HMOX1 HMOX1 OSR2 OSR2 PGF PGF BMPR1A BMPR1A MED1 MED1 PDPK1 PDPK1 FGFR2 FGFR2 THBS4 THBS4 TGFA TGFA CYP7B1 CYP7B1 SAAL1 SAAL1 ADAM17 ADAM17 BMP6 BMP6 HAS2 HAS2 FZD7 FZD7 EPGN EPGN SCN5A SCN5A BMPR2 BMPR2 APLN APLN FGFBP1 FGFBP1 ECM1 ECM1 CYBA CYBA RPTOR RPTOR SIRT6 SIRT6 SHH SHH AKT1 AKT1 RESP18 RESP18 TP63 TP63 SIRT1 SIRT1 REG3G REG3G ACVRL1 ACVRL1 FGF1 FGF1 GHSR GHSR SOX9 SOX9 VEGFD VEGFD ITGB3 ITGB3 IGF1 IGF1 STAT3 STAT3 B4GALT1 B4GALT1 RUNX2 RUNX2 PTPRN PTPRN TGFB1 TGFB1 PLXNB3 PLXNB3 PPP1R16B PPP1R16B PAX2 PAX2 ZNF580 ZNF580 GPBAR1 GPBAR1 EGR3 EGR3 PRKD1 PRKD1 CDH3 CDH3 ENSRBIP00000005036 ENSRBIP00000005036 ESRP2 ESRP2 EYA1 EYA1 JAML JAML NOG NOG HSF4 HSF4 HPN HPN NOD2 NOD2 STXBP4 STXBP4 KDR KDR F3 F3 DLX5 DLX5 FGF10 FGF10 NKX2-5 NKX2-5 STAT5A STAT5A TCF7L2 TCF7L2 PRKD2 PRKD2 APLNR APLNR VEGFC VEGFC DLX6 DLX6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HLXH2.0 like homeobox. (494 aa)
BMP2Bone morphogenetic protein 2. (321 aa)
HYAL1Hyaluronidase. (435 aa)
NF1Neurofibromin 1. (2822 aa)
BTKTyrosine-protein kinase. (673 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4094 aa)
BADBCL2 associated agonist of cell death. (167 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (249 aa)
IL10Interleukin 10. (178 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
VASH2Vasohibin 2. (355 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
MTA3Metastasis associated 1 family member 3. (585 aa)
IGF2Insulin like growth factor 2. (236 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
TBX1T-box transcription factor 1. (371 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1077 aa)
KDM5BLysine demethylase 5B. (1457 aa)
HMX2H6 family homeobox 2. (273 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
RREB1Ras responsive element binding protein 1. (1386 aa)
CCL26C-C motif chemokine. (94 aa)
SCG2Secretogranin II. (577 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1329 aa)
AGGF1Uncharacterized protein. (688 aa)
MYDGFMyeloid derived growth factor. (174 aa)
NOTCH2Notch receptor 2. (2532 aa)
ZNF304Zinc finger protein 304. (707 aa)
SP1Sp1 transcription factor. (769 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (388 aa)
SRSF6Serine and arginine rich splicing factor 6. (338 aa)
ODAMOdontogenic, ameloblast associated. (279 aa)
TGM1Transglutaminase 1. (808 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (409 aa)
AREGAmphiregulin. (264 aa)
CRNNCornulin. (495 aa)
NKX2-6NK2 homeobox 6. (301 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
PROX1Prospero homeobox 1. (737 aa)
ENSRBIP00000033881Uncharacterized protein. (61 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
PTNPleiotrophin. (168 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
CCL24C-C motif chemokine ligand 24. (111 aa)
PDX1Pancreatic and duodenal homeobox 1. (284 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
LAMC1Laminin subunit gamma 1. (1587 aa)
LACRTLacritin. (137 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GATA2GATA binding protein 2. (468 aa)
VIPVasoactive intestinal peptide. (167 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
NODALNodal growth differentiation factor. (347 aa)
TEKTEK receptor tyrosine kinase. (1123 aa)
ARG1Arginase. (322 aa)
ENSRBIP00000027339Nucleoside diphosphate kinase. (176 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
BMP5TGF_BETA_2 domain-containing protein. (154 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
HTRA1HtrA serine peptidase 1. (451 aa)
GDF2Growth differentiation factor 2. (429 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
CCND1Cyclin D1. (156 aa)
YAP1Yes associated protein 1. (326 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (729 aa)
JCADJunctional cadherin 5 associated. (1357 aa)
PROK1Prokineticin 1. (105 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1663 aa)
ZBED9Zinc finger BED-type containing 9. (1324 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
CTNNB1Catenin beta 1. (781 aa)
REG3ARegenerating family member 3 alpha. (175 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
LOC108525471Uncharacterized protein. (356 aa)
NOTCH1Notch receptor 1. (2438 aa)
VEGFBVascular endothelial growth factor B. (183 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ENSRBIP00000021702Uncharacterized protein. (144 aa)
XBP1BZIP domain-containing protein. (380 aa)
GRNGranulin precursor. (593 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
ZNF703Zinc finger protein 703. (589 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
SEMA5ASemaphorin 5A. (1035 aa)
RTN4Reticulon. (1172 aa)
EMC10ER membrane protein complex subunit 10. (351 aa)
MDKUncharacterized protein. (143 aa)
ENSRBIP00000019241Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (458 aa)
LOC108522656NR LBD domain-containing protein. (344 aa)
WDR48WD repeat domain 48. (644 aa)
FGFR1Fibroblast growth factor receptor. (829 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (237 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
SFRP1Secreted frizzled related protein 1. (313 aa)
IRS2Insulin receptor substrate 2. (904 aa)
MMP12Matrix metallopeptidase 12. (475 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (376 aa)
HMOX1Heme oxygenase 1. (284 aa)
OSR2Odd-skipped related transciption factor 2. (420 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1547 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (351 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
THBS4Thrombospondin 4. (961 aa)
TGFATransforming growth factor alpha. (166 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
SAAL1Serum amyloid A like 1. (529 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
BMP6Bone morphogenetic protein 6. (440 aa)
HAS2Hyaluronan synthase 2. (552 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
EPGNEpithelial mitogen. (156 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2016 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
APLNApelin. (77 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
ECM1Extracellular matrix protein 1. (540 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1309 aa)
SIRT6Sirtuin 6. (355 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
AKT1AKT serine/threonine kinase 1. (486 aa)
RESP18Regulated endocrine specific protein 18. (210 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
SIRT1Sirtuin 1. (731 aa)
REG3GRegenerating family member 3 gamma. (174 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SOX9SRY-box transcription factor 9. (305 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (788 aa)
IGF1Insulin like growth factor 1. (208 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (398 aa)
RUNX2RUNX family transcription factor 2. (610 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PLXNB3Plexin B3. (1909 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (567 aa)
PAX2Paired box 2. (242 aa)
ZNF580Zinc finger protein 580. (172 aa)
GPBAR1G protein-coupled bile acid receptor 1. (330 aa)
EGR3Early growth response 3. (387 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (892 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
ENSRBIP00000005036Cyclin N-terminal domain-containing protein. (74 aa)
ESRP2Epithelial splicing regulatory protein 2. (711 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
JAMLUncharacterized protein. (394 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (231 aa)
HSF4Heat shock transcription factor 4. (492 aa)
HPNHepsin; Belongs to the peptidase S1 family. (460 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1153 aa)
STXBP4Syntaxin binding protein 4. (322 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
F3Coagulation factor III, tissue factor. (296 aa)
DLX5Distal-less homeobox 5. (289 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NKX2-5NK2 homeobox 5. (325 aa)
STAT5ASignal transducer and activator of transcription. (738 aa)
TCF7L2HMG box domain-containing protein. (376 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (350 aa)
DLX6Distal-less homeobox 6. (263 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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