STRINGSTRING
ABCC8 ABCC8 ENSA ENSA PRKN PRKN TM7SF3 TM7SF3 ISL1 ISL1 GPR68 GPR68 CASR CASR FOXO1 FOXO1 ENSRBIP00000006344 ENSRBIP00000006344 MYRIP MYRIP PFKL PFKL SYT7 SYT7 NEUROD1 NEUROD1 KCNA5 KCNA5 KCNJ11 KCNJ11 SYT9 SYT9 PPP3CA-2 PPP3CA-2 ANO1 ANO1 ENSRBIP00000002993 ENSRBIP00000002993 STXBP4 STXBP4 TUNAR TUNAR PPP3CB PPP3CB PPP3CA PPP3CA ENSRBIP00000002079 ENSRBIP00000002079 SOX4 SOX4 CPT1A CPT1A CARTPT CARTPT ENSRBIP00000001234 ENSRBIP00000001234 TCF7L2 TCF7L2 HADH HADH SREBF1 SREBF1 TRPM2 TRPM2 ABAT ABAT PICK1 PICK1 HIF1A HIF1A PLA2G6 PLA2G6 VSNL1 VSNL1 ABCA12 ABCA12 PRKCE PRKCE EPHA5 EPHA5 LEP LEP IL6 IL6 GIPR GIPR BAD BAD BLK BLK RFX6 RFX6 LRP5L LRP5L OSBP OSBP SRI SRI SIDT2 SIDT2 SLC9B2 SLC9B2 MTNR1B MTNR1B PPARD PPARD SLC30A8 SLC30A8 ENSRBIP00000035558 ENSRBIP00000035558 NDUFAF2 NDUFAF2 ACVR1C ACVR1C PCK2 PCK2 CLOCK CLOCK STXBP5L STXBP5L NR1D1 NR1D1 PSMD9 PSMD9 KLF7 KLF7 ADCY5 ADCY5 FKBP1B FKBP1B TFAP2B TFAP2B DOC2B DOC2B C2CD2L C2CD2L ENSRBIP00000032719 ENSRBIP00000032719 GIP GIP STX4 STX4 IFNG IFNG EIPR1 EIPR1 NLGN2 NLGN2 LOC108528963 LOC108528963 PDX1 PDX1 RPH3AL RPH3AL CCL5 CCL5 PFKM PFKM BRSK2 BRSK2 GHRL GHRL FAM3D FAM3D SYTL4 SYTL4 TRPM4 TRPM4 CFTR CFTR NR0B2 NR0B2 MCU MCU GCG GCG BIRC5 BIRC5 PTPN11 PTPN11 LOC108525236 LOC108525236 ENSRBIP00000026419 ENSRBIP00000026419 TCIRG1 TCIRG1 LRRC8A LRRC8A HNF4A HNF4A GPLD1 GPLD1 MPC2 MPC2 ADCY8 ADCY8 HMGN3 HMGN3 KCNB1 KCNB1 EFNA5 EFNA5 SSTR5 SSTR5 GCK GCK TRH TRH CHGA CHGA CCN3 CCN3 C1QTNF12 C1QTNF12 SLC25A22 SLC25A22 CDK16 CDK16 CAPN10 CAPN10 NR1H4 NR1H4 RBP4 RBP4 IL1B IL1B ARNTL ARNTL RFX3 RFX3 ENSRBIP00000016878 ENSRBIP00000016878 SFRP1 SFRP1 IRS2 IRS2 ALOX5 ALOX5 ENSRBIP00000015369 ENSRBIP00000015369 BAIAP3 BAIAP3 GPER1 GPER1 HNF1A HNF1A REST REST IRS1 IRS1 NNAT NNAT FFAR1 FFAR1 MIDN MIDN SLC16A1 SLC16A1 SIRT6 SIRT6 SLC8B1 SLC8B1 ICA1 ICA1 G6PC2 G6PC2 FOXA2 FOXA2 SIRT4 SIRT4 ENSRBIP00000009767 ENSRBIP00000009767 PER2 PER2 GHSR GHSR INHBB INHBB CDV3 CDV3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABCC8ATP binding cassette subfamily C member 8. (1585 aa)
ENSAUncharacterized protein. (136 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
ISL1ISL LIM homeobox 1. (349 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CASRCalcium sensing receptor. (1078 aa)
FOXO1Forkhead box O1. (539 aa)
ENSRBIP00000006344C2H2-type domain-containing protein. (250 aa)
MYRIPMyosin VIIA and Rab interacting protein. (859 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (774 aa)
SYT7Synaptotagmin 7. (672 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
SYT9Synaptotagmin 9. (442 aa)
PPP3CA-2Uncharacterized protein. (70 aa)
ANO1Anoctamin. (962 aa)
ENSRBIP00000002993Uncharacterized protein. (237 aa)
STXBP4Syntaxin binding protein 4. (322 aa)
TUNARTCL1 upstream neural differentiation-associated RNA. (48 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
PPP3CASerine/threonine-protein phosphatase. (310 aa)
ENSRBIP00000002079Uncharacterized protein. (202 aa)
SOX4Transcription factor SOX. (475 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (762 aa)
CARTPTCART prepropeptide. (116 aa)
ENSRBIP00000001234Uncharacterized protein. (93 aa)
TCF7L2HMG box domain-containing protein. (376 aa)
HADHHydroxyacyl-CoA dehydrogenase. (341 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1047 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1552 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (506 aa)
PICK1Protein interacting with PRKCA 1. (415 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
VSNL1Visinin like 1. (191 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
EPHA5EPH receptor A5. (1038 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
IL6Interleukin 6. (214 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
BADBCL2 associated agonist of cell death. (167 aa)
BLKTyrosine-protein kinase. (505 aa)
RFX6Regulatory factor X6. (916 aa)
LRP5LLDL receptor related protein 5 like. (251 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (791 aa)
SRISorcin. (198 aa)
SIDT2SID1 transmembrane family member 2. (855 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
ENSRBIP00000035558Uncharacterized protein. (101 aa)
NDUFAF2NADH:ubiquinone oxidoreductase complex assembly factor 2. (111 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (413 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
CLOCKClock circadian regulator. (847 aa)
STXBP5LSyntaxin binding protein 5 like. (1180 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
PSMD9PDZ domain-containing protein. (223 aa)
KLF7Kruppel like factor 7. (302 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
TFAP2BTranscription factor AP-2 beta. (442 aa)
DOC2BDouble C2-like domain-containing protein. (406 aa)
C2CD2LC2CD2 like. (707 aa)
ENSRBIP00000032719SH2 domain-containing protein. (203 aa)
GIPGastric inhibitory polypeptide. (151 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (297 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
EIPR1EARP complex and GARP complex interacting protein 1. (387 aa)
NLGN2Neuroligin 2. (698 aa)
LOC108528963ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
PDX1Pancreatic and duodenal homeobox 1. (284 aa)
RPH3ALRabphilin 3A like (without C2 domains). (311 aa)
CCL5C-C motif chemokine. (91 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
BRSK2BR serine/threonine kinase 2. (756 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
FAM3DFamily with sequence similarity 3 member D. (224 aa)
SYTL4Synaptotagmin like 4. (672 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1052 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
MCUMitochondrial calcium uniporter. (351 aa)
GCGGlucagon. (180 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
LOC108525236Uncharacterized protein. (137 aa)
ENSRBIP00000026419Uncharacterized protein. (249 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (847 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
HMGN3High mobility group nucleosomal binding domain 3. (117 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (364 aa)
GCKPhosphotransferase. (466 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (242 aa)
CHGAChromogranin A. (510 aa)
CCN3Cellular communication network factor 3. (357 aa)
C1QTNF12C1q and TNF related 12. (278 aa)
SLC25A22Solute carrier family 25 member 22; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
CDK16Cyclin dependent kinase 16. (570 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (672 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (481 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (201 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (594 aa)
RFX3Regulatory factor X3. (668 aa)
ENSRBIP00000016878Uncharacterized protein. (251 aa)
SFRP1Secreted frizzled related protein 1. (313 aa)
IRS2Insulin receptor substrate 2. (904 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
ENSRBIP00000015369Uncharacterized protein. (89 aa)
BAIAP3BAI1 associated protein 3. (1186 aa)
GPER1G protein-coupled estrogen receptor 1. (373 aa)
HNF1AHNF1 homeobox A. (662 aa)
RESTRE1 silencing transcription factor. (1080 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
NNATNeuronatin. (80 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
MIDNMidnolin. (385 aa)
SLC16A1Solute carrier family 16 member 1. (500 aa)
SIRT6Sirtuin 6. (355 aa)
SLC8B1Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (583 aa)
ICA1Islet cell autoantigen 1. (512 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
FOXA2Forkhead box A2. (463 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
ENSRBIP00000009767Uncharacterized protein. (546 aa)
PER2Period circadian regulator 2. (1311 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
INHBBInhibin subunit beta B. (407 aa)
CDV3CDV3 homolog. (244 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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