(18 nodes) Positive regulation of type I interferon-mediated signaling pathway network (Rhinopithecus bieti)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108541675	Uncharacterized protein. (423 aa)
	STING1	Transmembrane protein 173. (379 aa)
	UBE2K	Ubiquitin conjugating enzyme E2 K. (190 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
	TRIM41	Tripartite motif containing 41. (612 aa)
	TBK1	TANK binding kinase 1. (681 aa)
	NLRC5	NLR family CARD domain containing 5. (1866 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	ZBP1	Z-DNA binding protein 1. (451 aa)
	MMP12	Matrix metallopeptidase 12. (475 aa)
	ENSRBIP00000013354	IRF-3 domain-containing protein. (139 aa)
	IRF3	IRF tryptophan pentad repeat domain-containing protein. (426 aa)
	RNF185	Ring finger protein 185. (195 aa)
	TRIM56	Tripartite motif containing 56. (755 aa)
	LSM14A	Uncharacterized protein. (401 aa)
	MAVS	Mitochondrial antiviral signaling protein. (539 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
	USP27X	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (438 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSRBIP00000013354	IKBKE	ENSRBIP00000013354	ENSRBIP00000004507	IRF-3 domain-containing protein.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.877
ENSRBIP00000013354	MAVS	ENSRBIP00000013354	ENSRBIP00000019791	IRF-3 domain-containing protein.	Mitochondrial antiviral signaling protein.	0.900
ENSRBIP00000013354	STING1	ENSRBIP00000013354	ENSRBIP00000023194	IRF-3 domain-containing protein.	Transmembrane protein 173.	0.912
ENSRBIP00000013354	TBK1	ENSRBIP00000013354	ENSRBIP00000030823	IRF-3 domain-containing protein.	TANK binding kinase 1.	0.953
ENSRBIP00000013354	ZBP1	ENSRBIP00000013354	ENSRBIP00000043074	IRF-3 domain-containing protein.	Z-DNA binding protein 1.	0.503
FADD	MAVS	ENSRBIP00000026089	ENSRBIP00000019791	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Mitochondrial antiviral signaling protein.	0.649
FADD	TBK1	ENSRBIP00000026089	ENSRBIP00000030823	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	TANK binding kinase 1.	0.462
FADD	ZBP1	ENSRBIP00000026089	ENSRBIP00000043074	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Z-DNA binding protein 1.	0.412
IKBKE	ENSRBIP00000013354	ENSRBIP00000004507	ENSRBIP00000013354	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	IRF-3 domain-containing protein.	0.877
IKBKE	IRF3	ENSRBIP00000004507	ENSRBIP00000012796	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	IRF tryptophan pentad repeat domain-containing protein.	0.987
IKBKE	MAVS	ENSRBIP00000004507	ENSRBIP00000019791	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Mitochondrial antiviral signaling protein.	0.983
IKBKE	STING1	ENSRBIP00000004507	ENSRBIP00000023194	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Transmembrane protein 173.	0.993
IKBKE	TBK1	ENSRBIP00000004507	ENSRBIP00000030823	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	TANK binding kinase 1.	0.991
IKBKE	ZBP1	ENSRBIP00000004507	ENSRBIP00000043074	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Z-DNA binding protein 1.	0.947
IRF3	IKBKE	ENSRBIP00000012796	ENSRBIP00000004507	IRF tryptophan pentad repeat domain-containing protein.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.987
IRF3	MAVS	ENSRBIP00000012796	ENSRBIP00000019791	IRF tryptophan pentad repeat domain-containing protein.	Mitochondrial antiviral signaling protein.	0.900
IRF3	STING1	ENSRBIP00000012796	ENSRBIP00000023194	IRF tryptophan pentad repeat domain-containing protein.	Transmembrane protein 173.	0.912
IRF3	TBK1	ENSRBIP00000012796	ENSRBIP00000030823	IRF tryptophan pentad repeat domain-containing protein.	TANK binding kinase 1.	0.953
IRF3	ZBP1	ENSRBIP00000012796	ENSRBIP00000043074	IRF tryptophan pentad repeat domain-containing protein.	Z-DNA binding protein 1.	0.948
MAVS	ENSRBIP00000013354	ENSRBIP00000019791	ENSRBIP00000013354	Mitochondrial antiviral signaling protein.	IRF-3 domain-containing protein.	0.900