(17 nodes) Positive regulation of SMAD protein signal transduction network (Rhinopithecus bieti)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DAB2	DAB adaptor protein 2. (756 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
	BMP2	Bone morphogenetic protein 2. (321 aa)
	JAK2	Tyrosine-protein kinase. (1083 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
	NODAL	Nodal growth differentiation factor. (347 aa)
	RBPMS	RNA binding protein, mRNA processing factor. (243 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	KIAA0319	KIAA0319. (1031 aa)
	ENSRBIP00000019241	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (458 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	NUP93	Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (880 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	BMP6	Bone morphogenetic protein 6. (440 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP4	ENSRBIP00000043407	ENSRBIP00000039189	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.413
BMP2	BMP6	ENSRBIP00000043407	ENSRBIP00000013611	Bone morphogenetic protein 2.	Bone morphogenetic protein 6.	0.615
BMP2	BMPR1A	ENSRBIP00000043407	ENSRBIP00000015119	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.949
BMP2	BMPR2	ENSRBIP00000043407	ENSRBIP00000012877	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.931
BMP2	ENSRBIP00000019241	ENSRBIP00000043407	ENSRBIP00000019241	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.949
BMP2	SMAD4	ENSRBIP00000043407	ENSRBIP00000018874	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.851
BMP2	TGFBR1	ENSRBIP00000043407	ENSRBIP00000034156	Bone morphogenetic protein 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.694
BMP4	BMP2	ENSRBIP00000039189	ENSRBIP00000043407	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.413
BMP4	BMP6	ENSRBIP00000039189	ENSRBIP00000013611	Bone morphogenetic protein 4.	Bone morphogenetic protein 6.	0.959
BMP4	BMPR1A	ENSRBIP00000039189	ENSRBIP00000015119	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.988
BMP4	BMPR2	ENSRBIP00000039189	ENSRBIP00000012877	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.990
BMP4	ENSRBIP00000019241	ENSRBIP00000039189	ENSRBIP00000019241	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.889
BMP4	SMAD4	ENSRBIP00000039189	ENSRBIP00000018874	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.869
BMP4	TGFBR1	ENSRBIP00000039189	ENSRBIP00000034156	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.695
BMP6	BMP2	ENSRBIP00000013611	ENSRBIP00000043407	Bone morphogenetic protein 6.	Bone morphogenetic protein 2.	0.615
BMP6	BMP4	ENSRBIP00000013611	ENSRBIP00000039189	Bone morphogenetic protein 6.	Bone morphogenetic protein 4.	0.959
BMP6	BMPR1A	ENSRBIP00000013611	ENSRBIP00000015119	Bone morphogenetic protein 6.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.967
BMP6	BMPR2	ENSRBIP00000013611	ENSRBIP00000012877	Bone morphogenetic protein 6.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.975
BMP6	ENSRBIP00000019241	ENSRBIP00000013611	ENSRBIP00000019241	Bone morphogenetic protein 6.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.686
BMP6	SMAD4	ENSRBIP00000013611	ENSRBIP00000018874	Bone morphogenetic protein 6.	Mothers against decapentaplegic homolog.	0.532