STRINGSTRING
GDF2 GDF2 BMP2 BMP2 BMP7 BMP7 LEFTY1 LEFTY1 BMP4 BMP4 ACVR2A ACVR2A GDF11 GDF11 ENG ENG TGFBR1 TGFBR1 TWSG1 TWSG1 SMAD6 SMAD6 NODAL NODAL RBPMS RBPMS SMAD7 SMAD7 LOC108522423 LOC108522423 INHBE INHBE BMP5 BMP5 TGFB3 TGFB3 LOC108538722 LOC108538722 DKK1 DKK1 INHA INHA TGFBR2 TGFBR2 XBP1 XBP1 INHBA INHBA BMPER BMPER GDF10 GDF10 EMILIN1 EMILIN1 ENSRBIP00000019241 ENSRBIP00000019241 GDF3 GDF3 BMP3 BMP3 SMAD4 SMAD4 GDF5 GDF5 ENSRBIP00000017597 ENSRBIP00000017597 HFE HFE LDLRAD4 LDLRAD4 LRP1 LRP1 SDCBP SDCBP BMPR1A BMPR1A BMP15 BMP15 GDF7 GDF7 BMP6 BMP6 BMPR2 BMPR2 BMP10 BMP10 ENSRBIP00000012047 ENSRBIP00000012047 ENSRBIP00000012040 ENSRBIP00000012040 ACVRL1 ACVRL1 INHBB INHBB DAB2 DAB2 ACVR1 ACVR1 TGFB1 TGFB1 PIN1 PIN1 LOC108517059 LOC108517059 ENSRBIP00000005444 ENSRBIP00000005444 PMEPA1 PMEPA1 NOG NOG TGFB2 TGFB2 GDF6 GDF6 INHBC INHBC LOC108517065 LOC108517065
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDF2Growth differentiation factor 2. (429 aa)
BMP2Bone morphogenetic protein 2. (321 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
LEFTY1Left-right determination factor. (366 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
GDF11Growth differentiation factor 11. (348 aa)
ENGEndoglin. (607 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
SMAD6Mothers against decapentaplegic homolog. (452 aa)
NODALNodal growth differentiation factor. (347 aa)
RBPMSRNA binding protein, mRNA processing factor. (243 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
LOC108522423PX domain-containing protein. (420 aa)
INHBEInhibin subunit beta E. (351 aa)
BMP5TGF_BETA_2 domain-containing protein. (154 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LOC108538722TGF_BETA_2 domain-containing protein. (262 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (367 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
XBP1BZIP domain-containing protein. (380 aa)
INHBAInhibin subunit beta A. (426 aa)
BMPERBMP binding endothelial regulator. (685 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa)
EMILIN1Elastin microfibril interfacer 1. (620 aa)
ENSRBIP00000019241Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (458 aa)
GDF3Growth differentiation factor 3. (364 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (474 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GDF5Growth differentiation factor 5. (499 aa)
ENSRBIP00000017597PXA domain-containing protein. (147 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (306 aa)
LRP1LDL receptor related protein 1. (4461 aa)
SDCBPSyndecan binding protein. (329 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
GDF7Growth differentiation factor 7. (432 aa)
BMP6Bone morphogenetic protein 6. (440 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ENSRBIP00000012047Peptidyl-prolyl cis-trans isomerase. (154 aa)
ENSRBIP00000012040PDZ domain-containing protein. (305 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
INHBBInhibin subunit beta B. (407 aa)
DAB2DAB adaptor protein 2. (756 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (511 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
LOC108517059TGF_BETA_2 domain-containing protein. (402 aa)
ENSRBIP00000005444PDZ domain-containing protein. (212 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (268 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (231 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
GDF6Growth differentiation factor 6. (455 aa)
INHBCInhibin subunit beta C. (352 aa)
LOC108517065TGF_BETA_2 domain-containing protein. (261 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.