STRINGSTRING
LOC108513918 LOC108513918 PRKAA1 PRKAA1 NOS1 NOS1 GCG GCG GUCA1A GUCA1A ENSRBIP00000027656 ENSRBIP00000027656 TREM2 TREM2 ZBTB20 ZBTB20 PPP1R3E PPP1R3E PID1 PID1 ADCYAP1R1 ADCYAP1R1 HTR2A HTR2A GUCA1B GUCA1B FABP1 FABP1 PTPN2 PTPN2 SORBS1 SORBS1 BEND3 BEND3 IFNG IFNG PLA2G3 PLA2G3 ARPP19 ARPP19 ENSRBIP00000032659 ENSRBIP00000032659 RCVRN RCVRN ABCG4 ABCG4 AKT2 AKT2 NOS3 NOS3 ADORA2B ADORA2B NR1D1 NR1D1 NNMT NNMT PPARD PPARD AVP AVP SLC45A3 SLC45A3 PPARG PPARG CD74 CD74 GPD1 GPD1 APP APP PRKAA2 PRKAA2 CLYBL CLYBL IGF2 IGF2 KAT2A KAT2A EPM2AIP1 EPM2AIP1 P2RY6 P2RY6 SREBF1 SREBF1 NR1H3 NR1H3 WNT4 WNT4 RDH10 RDH10 GUCA2A GUCA2A MID1IP1 MID1IP1 CPT1A CPT1A SRC SRC VCP VCP PLIN5 PLIN5 LPGAT1 LPGAT1 MLST8 MLST8 GUCA2B GUCA2B MLXIPL MLXIPL PSEN1 PSEN1 MAS1 MAS1 MTOR MTOR PTH PTH ACTN3 ACTN3 LOC108526381 LOC108526381 P2RY1 P2RY1 FOXO1 FOXO1 GUCA1C GUCA1C STK11 STK11 ABCG1 ABCG1 ENSRBIP00000007280 ENSRBIP00000007280 AAED1 AAED1 PPARA PPARA SCAP SCAP KAT2B KAT2B POR POR ENSRBIP00000008335 ENSRBIP00000008335 DAB2 DAB2 SREBF2 SREBF2 IGF1 IGF1 LOC108522821 LOC108522821 GHSR GHSR ENSRBIP00000009622 ENSRBIP00000009622 FGF1 FGF1 LHCGR LHCGR SIRT1 SIRT1 PINK1 PINK1 AKT1 AKT1 P2RX7 P2RX7 RPTOR RPTOR MLYCD MLYCD CD244 CD244 ADIPOQ ADIPOQ ENSRBIP00000011851 ENSRBIP00000011851 WDR5 WDR5 IRS1 IRS1 BMP6 BMP6 GPT GPT CYP7A1 CYP7A1 HNF1A HNF1A DYRK2 DYRK2 LDLRAP1 LDLRAP1 GPER1 GPER1 MTLN MTLN APOA5 APOA5 SLC4A4 SLC4A4 STAR STAR PHKG2 PHKG2 IRS2 IRS2 PPARGC1A PPARGC1A STARD4 STARD4 ABCD2 ABCD2 IL1B IL1B PPARG-2 PPARG-2 NR1H4 NR1H4 AVPR1A AVPR1A AVPR1B AVPR1B DDB1 DDB1 NTSR1 NTSR1 GCK GCK APOE APOE APOC2 APOC2 DGAT2 DGAT2 NR1H2 NR1H2 PTGS2 PTGS2 GPLD1 GPLD1 INSR INSR PARK7 PARK7 NR4A3 NR4A3 HIF1A HIF1A ARNT ARNT PRKCE PRKCE ADM ADM ABCD1 ABCD1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108513918Uncharacterized protein. (875 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1333 aa)
GCGGlucagon. (180 aa)
GUCA1AUncharacterized protein. (202 aa)
ENSRBIP00000027656START domain-containing protein. (252 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (231 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
PPP1R3EProtein phosphatase 1 regulatory subunit 3E. (266 aa)
PID1Phosphotyrosine interaction domain containing 1. (250 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (577 aa)
HTR2A5-hydroxytryptamine receptor 2A. (472 aa)
GUCA1BGuanylate cyclase activator 1B. (200 aa)
FABP1Fatty acid binding protein 1. (127 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (387 aa)
SORBS1Sorbin and SH3 domain containing 1. (1294 aa)
BEND3BEN domain containing 3. (828 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
PLA2G3Phospholipase A2 group III. (508 aa)
ARPP19Uncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (131 aa)
ENSRBIP00000032659Uncharacterized protein. (211 aa)
RCVRNRecoverin. (200 aa)
ABCG4ATP binding cassette subfamily G member 4. (646 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (394 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
NNMTNicotinamide N-methyltransferase. (264 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
AVPArginine vasopressin; Belongs to the vasopressin/oxytocin family. (164 aa)
SLC45A3Solute carrier family 45 member 3. (553 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (298 aa)
CD74CD74 molecule. (294 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
APPAmyloid beta precursor protein. (770 aa)
PRKAA2Non-specific serine/threonine protein kinase. (539 aa)
CLYBLCitrate lyase beta like. (340 aa)
IGF2Insulin like growth factor 2. (236 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
EPM2AIP1EPM2A interacting protein 1. (607 aa)
P2RY6Pyrimidinergic receptor P2Y6. (290 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1047 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (441 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
GUCA2AGuanylate cyclase activator 2A. (115 aa)
MID1IP1MID1 interacting protein 1. (183 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (762 aa)
SRCTyrosine-protein kinase. (627 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (806 aa)
PLIN5Perilipin; Belongs to the perilipin family. (462 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (357 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
GUCA2BGuanylate cyclase activator 2B. (112 aa)
MLXIPLMLX interacting protein like. (798 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (432 aa)
MAS1MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (937 aa)
LOC108526381Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (560 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
FOXO1Forkhead box O1. (539 aa)
GUCA1CGuanylate cyclase activator 1C. (209 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
ABCG1ATP binding cassette subfamily G member 1. (676 aa)
ENSRBIP00000007280Tyrosine-protein phosphatase non-receptor type. (354 aa)
AAED1Uncharacterized protein. (213 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
SCAPSREBF chaperone. (1469 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (798 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (729 aa)
ENSRBIP00000008335Uncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (68 aa)
DAB2DAB adaptor protein 2. (756 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1138 aa)
IGF1Insulin like growth factor 1. (208 aa)
LOC108522821Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (502 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ENSRBIP00000009622Uncharacterized protein. (329 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (645 aa)
SIRT1Sirtuin 1. (731 aa)
PINK1PTEN induced kinase 1. (581 aa)
AKT1AKT serine/threonine kinase 1. (486 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1309 aa)
MLYCDMalonyl-CoA decarboxylase. (493 aa)
CD244CD244 molecule. (367 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (275 aa)
ENSRBIP00000011851Uncharacterized protein. (107 aa)
WDR5WD repeat domain 5. (334 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
BMP6Bone morphogenetic protein 6. (440 aa)
GPTGlutamic--pyruvic transaminase. (490 aa)
CYP7A1Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family. (405 aa)
HNF1AHNF1 homeobox A. (662 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (595 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (278 aa)
GPER1G protein-coupled estrogen receptor 1. (373 aa)
MTLNMitoregulin. (111 aa)
APOA5Apolipoprotein A5. (366 aa)
SLC4A4Anion exchange protein. (1110 aa)
STARSteroidogenic acute regulatory protein. (294 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (410 aa)
IRS2Insulin receptor substrate 2. (904 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
STARD4StAR related lipid transfer domain containing 4. (205 aa)
ABCD2ATP binding cassette subfamily D member 2. (740 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
PPARG-2Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (217 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (481 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (421 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (424 aa)
DDB1Damage specific DNA binding protein 1. (1140 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
GCKPhosphotransferase. (466 aa)
APOEApolipoprotein E. (317 aa)
APOC2Apolipoprotein C2. (101 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (847 aa)
INSRTyrosine-protein kinase receptor. (1372 aa)
PARK7Parkinsonism associated deglycase. (191 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (637 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ADMAdrenomedullin. (185 aa)
ABCD1ATP binding cassette subfamily D member 1. (734 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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