56 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WWP2	E3 ubiquitin-protein ligase. (870 aa)
	UBE2G1	Ubiquitin conjugating enzyme E2 G1; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
	MAGEL2	MAGE family member L2. (1198 aa)
	UBE2E3	Ubiquitin conjugating enzyme E2 E3; Belongs to the ubiquitin-conjugating enzyme family. (207 aa)
	BFAR	Bifunctional apoptosis regulator. (450 aa)
	UBE2O	Ubiquitin conjugating enzyme E2 O. (1324 aa)
	HECTD1	HECT domain E3 ubiquitin protein ligase 1. (2472 aa)
	RNF186	Ring finger protein 186. (224 aa)
	RNF8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (468 aa)
	UBE2V1-2	UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
	UBE2NL	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
	TRIM56	Tripartite motif containing 56. (755 aa)
	TRIM27	Tripartite motif containing 27. (513 aa)
	LOC108520651	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	TRIM21	Tripartite motif containing 21. (475 aa)
	ENSRBIP00000006958	TNF receptor-associated factor. (473 aa)
	RNF4	Ring finger protein 4. (190 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
	ENSRBIP00000007797	Uncharacterized protein. (186 aa)
	LOC108526191	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (112 aa)
	TRAF3IP2	TRAF3 interacting protein 2. (563 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (563 aa)
	TRAF1	TNF receptor-associated factor. (416 aa)
	STUB1	STIP1 homology and U-box containing protein 1. (303 aa)
	ZFP91	Uncharacterized protein. (562 aa)
	ENSRBIP00000011806	UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
	TRIM5	Uncharacterized protein. (486 aa)
	RNF152	Ring finger protein 152. (203 aa)
	PELI3	Pellino E3 ubiquitin protein ligase family member 3. (397 aa)
	UBE2S	Ubiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
	RNF213	Ring finger protein 213. (5215 aa)
	ENSRBIP00000014363	UBIQUITIN_CONJUGAT_2 domain-containing protein. (128 aa)
	ENSRBIP00000014751	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (105 aa)
	ENSRBIP00000014902	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (94 aa)
	ENSRBIP00000015432	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (173 aa)
	RNF135	Ring finger protein 135. (421 aa)
	CDKN2A	Uncharacterized protein. (173 aa)
	LOC108517237	Uncharacterized protein. (89 aa)
	ENSRBIP00000019157	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (78 aa)
	ENSRBIP00000020891	Uncharacterized protein. (64 aa)
	UBE2V2	Ubiquitin conjugating enzyme E2 V2. (144 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (418 aa)
	ITCH	E3 ubiquitin-protein ligase. (862 aa)
	RNF5	Ring finger protein 5. (180 aa)
	PRPF19	Pre-mRNA processing factor 19. (518 aa)
	NEDD4	NEDD4 E3 ubiquitin protein ligase. (1224 aa)
	FBXW9	F-box and WD repeat domain containing 9. (458 aa)
	UBE2T	Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (240 aa)
	RNF115	Ring finger protein 115. (304 aa)
	RNF168	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
	UBE2D4	Ubiquitin conjugating enzyme E2 D4 (putative); Belongs to the ubiquitin-conjugating enzyme family. (173 aa)
	ENSRBIP00000033406	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	ARIH2	RBR-type E3 ubiquitin transferase. (493 aa)
	TRAF3	TNF receptor-associated factor. (477 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BFAR	RNF8	ENSRBIP00000002263	ENSRBIP00000004033	Bifunctional apoptosis regulator.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.435
ENSRBIP00000006958	ENSRBIP00000011806	ENSRBIP00000006958	ENSRBIP00000011806	TNF receptor-associated factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.474
ENSRBIP00000006958	ENSRBIP00000014363	ENSRBIP00000006958	ENSRBIP00000014363	TNF receptor-associated factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.604
ENSRBIP00000006958	ENSRBIP00000014751	ENSRBIP00000006958	ENSRBIP00000014751	TNF receptor-associated factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.727
ENSRBIP00000006958	ENSRBIP00000019157	ENSRBIP00000006958	ENSRBIP00000019157	TNF receptor-associated factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.727
ENSRBIP00000006958	ENSRBIP00000020891	ENSRBIP00000006958	ENSRBIP00000020891	TNF receptor-associated factor.	Uncharacterized protein.	0.679
ENSRBIP00000006958	ENSRBIP00000033406	ENSRBIP00000006958	ENSRBIP00000033406	TNF receptor-associated factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.712
ENSRBIP00000006958	ITCH	ENSRBIP00000006958	ENSRBIP00000024021	TNF receptor-associated factor.	E3 ubiquitin-protein ligase.	0.595
ENSRBIP00000006958	LOC108520651	ENSRBIP00000006958	ENSRBIP00000005853	TNF receptor-associated factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.727
ENSRBIP00000006958	LOC108526191	ENSRBIP00000006958	ENSRBIP00000007914	TNF receptor-associated factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.727
ENSRBIP00000006958	PELI1	ENSRBIP00000006958	ENSRBIP00000023743	TNF receptor-associated factor.	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.	0.725
ENSRBIP00000006958	PELI3	ENSRBIP00000006958	ENSRBIP00000012489	TNF receptor-associated factor.	Pellino E3 ubiquitin protein ligase family member 3.	0.745
ENSRBIP00000006958	STUB1	ENSRBIP00000006958	ENSRBIP00000011071	TNF receptor-associated factor.	STIP1 homology and U-box containing protein 1.	0.452
ENSRBIP00000006958	TRAF1	ENSRBIP00000006958	ENSRBIP00000010995	TNF receptor-associated factor.	TNF receptor-associated factor.	0.731
ENSRBIP00000006958	TRAF2	ENSRBIP00000006958	ENSRBIP00000031083	TNF receptor-associated factor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.827
ENSRBIP00000006958	TRAF3	ENSRBIP00000006958	ENSRBIP00000042322	TNF receptor-associated factor.	TNF receptor-associated factor.	0.859
ENSRBIP00000006958	TRAF3IP2	ENSRBIP00000006958	ENSRBIP00000008973	TNF receptor-associated factor.	TRAF3 interacting protein 2.	0.781
ENSRBIP00000006958	TRAF5	ENSRBIP00000006958	ENSRBIP00000009610	TNF receptor-associated factor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.929
ENSRBIP00000006958	UBE2NL	ENSRBIP00000006958	ENSRBIP00000004804	TNF receptor-associated factor.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.727
ENSRBIP00000006958	UBE2S	ENSRBIP00000006958	ENSRBIP00000012688	TNF receptor-associated factor.	Ubiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family.	0.522