STRINGSTRING
TRIM63 TRIM63 IL1B IL1B SFRP1 SFRP1 CCL1 CCL1 LOC108526722 LOC108526722 CCL21 CCL21 HYAL3 HYAL3 DAB2IP DAB2IP HAS2 HAS2 ENSRBIP00000012634 ENSRBIP00000012634 NFKB1 NFKB1 CYBA CYBA CCL16 CCL16 MYD88 MYD88 GBP2 GBP2 IL1R1 IL1R1 INHBB INHBB TNFRSF11A TNFRSF11A CCL20 CCL20 PCSK1 PCSK1 MYLK3 MYLK3 IL1RL2 IL1RL2 PLCB1 PLCB1 ENSRBIP00000006958 ENSRBIP00000006958 IRAK3 IRAK3 CXCL8 CXCL8 LOC108526721 LOC108526721 ST18 ST18 RORA RORA NKX3-1 NKX3-1 ANKRD1 ANKRD1 RIPK2 RIPK2 EGR1 EGR1 AKAP12 AKAP12 GBP3 GBP3 UPF1 UPF1 SRC SRC CACTIN CACTIN TNIP2 TNIP2 PTGIS PTGIS FN1 FN1 MAPK3 MAPK3 TLE5 TLE5 HYAL1 HYAL1 IL17A IL17A ADAMTS12 ADAMTS12 CHI3L1 CHI3L1 HIF1A HIF1A IRAK4 IRAK4 PYCARD PYCARD ENSRBIP00000038500 ENSRBIP00000038500 ZC3H12A ZC3H12A CCL26 CCL26 RPS6KA5 RPS6KA5 MAP2K7 MAP2K7 TRAF6 TRAF6 SLC30A8 SLC30A8 KMO KMO FGG FGG NR1D1 NR1D1 MAPK11 MAPK11 CCL8 CCL8 MAPK13 MAPK13 SELE SELE RPS6KA4 RPS6KA4 CCL17 CCL17 LOC108539097 LOC108539097 CCL24 CCL24 LOC108514681 LOC108514681 CCL5 CCL5 CCL19 CCL19 USP10 USP10 IRAK2 IRAK2 CCL14 CCL14 LOC108541410 LOC108541410 KLF2 KLF2 ENSRBIP00000027860 ENSRBIP00000027860 IKBKB IKBKB RC3H1 RC3H1 CCL13 CCL13 LOC108539397 LOC108539397 IRAK1 IRAK1 CCL23 CCL23 TANK TANK SMPD1 SMPD1 GCLC GCLC CCL22 CCL22 SIRPA SIRPA ENSRBIP00000022247 ENSRBIP00000022247 FGB FGB CX3CL1 CX3CL1 TOLLIP TOLLIP HDAC4 HDAC4 CITED1 CITED1 MMP2 MMP2 PRKCA PRKCA CCL18 CCL18 HYAL2 HYAL2 ACOD1 ACOD1 RELA RELA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRIM63Tripartite motif containing 63. (383 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
SFRP1Secreted frizzled related protein 1. (313 aa)
CCL1C-C motif chemokine. (96 aa)
LOC108526722SCY domain-containing protein. (114 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
DAB2IPDAB2 interacting protein. (1156 aa)
HAS2Hyaluronan synthase 2. (552 aa)
ENSRBIP00000012634RRM domain-containing protein. (343 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
CCL16C-C motif chemokine. (120 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
GBP2Guanylate binding protein 2. (490 aa)
IL1R1Interleukin 1 receptor type 1. (568 aa)
INHBBInhibin subunit beta B. (407 aa)
TNFRSF11ATNF receptor superfamily member 11a. (614 aa)
CCL20C-C motif chemokine. (96 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (749 aa)
MYLK3Myosin light chain kinase 3. (818 aa)
IL1RL2Interleukin 1 receptor like 2. (652 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
ENSRBIP00000006958TNF receptor-associated factor. (473 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (596 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
LOC108526721SCY domain-containing protein. (114 aa)
ST18ST18 C2H2C-type zinc finger transcription factor. (1038 aa)
RORARAR related orphan receptor A. (555 aa)
NKX3-1NK3 homeobox 1. (230 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (443 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
AKAP12A-kinase anchoring protein 12. (1783 aa)
GBP3Guanylate binding protein 3. (595 aa)
UPF1UPF1 RNA helicase and ATPase. (1068 aa)
SRCTyrosine-protein kinase. (627 aa)
CACTINCactin, spliceosome C complex subunit. (804 aa)
TNIP2CCHC NOA-type domain-containing protein. (337 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
FN1Fibronectin 1. (2477 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
TLE5TLE family member 5, transcriptional modulator. (264 aa)
HYAL1Hyaluronidase. (435 aa)
IL17AInterleukin 17A. (155 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1597 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (405 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (461 aa)
PYCARDPYD and CARD domain containing. (195 aa)
ENSRBIP00000038500RHD domain-containing protein. (112 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (570 aa)
CCL26C-C motif chemokine. (94 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (684 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (414 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
KMOKynurenine 3-monooxygenase. (431 aa)
FGGFibrinogen gamma chain. (453 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
CCL8C-C motif chemokine. (99 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
SELESelectin E. (610 aa)
RPS6KA4Ribosomal protein S6 kinase. (771 aa)
CCL17C-C motif chemokine. (91 aa)
LOC108539097C-C motif chemokine. (109 aa)
CCL24C-C motif chemokine ligand 24. (111 aa)
LOC108514681Uncharacterized protein. (252 aa)
CCL5C-C motif chemokine. (91 aa)
CCL19C-C motif chemokine. (98 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (802 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (537 aa)
CCL14C-C motif chemokine. (92 aa)
LOC108541410SCY domain-containing protein. (102 aa)
KLF2Uncharacterized protein. (194 aa)
ENSRBIP00000027860RRM domain-containing protein. (357 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
RC3H1Ring finger and CCCH-type domains 1. (1134 aa)
CCL13C-C motif chemokine. (98 aa)
LOC108539397SCY domain-containing protein. (112 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (702 aa)
CCL23C-C motif chemokine. (120 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
CCL22C-C motif chemokine. (93 aa)
SIRPAUncharacterized protein. (505 aa)
ENSRBIP00000022247Uncharacterized protein. (70 aa)
FGBFibrinogen beta chain. (491 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (407 aa)
TOLLIPToll interacting protein. (274 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1112 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (604 aa)
CCL18C-C motif chemokine. (66 aa)
HYAL2Hyaluronidase. (467 aa)
ACOD1Aconitate decarboxylase 1. (458 aa)
RELAUncharacterized protein. (282 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
Server load: low (16%) [HD]