83 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CACTIN	Cactin, spliceosome C complex subunit. (804 aa)
	UPF1	UPF1 RNA helicase and ATPase. (1068 aa)
	GBP3	Guanylate binding protein 3. (595 aa)
	AKAP12	A-kinase anchoring protein 12. (1783 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
	ANKRD1	Ankyrin repeat domain 1. (319 aa)
	NKX3-1	NK3 homeobox 1. (230 aa)
	RORA	RAR related orphan receptor A. (555 aa)
	TNIP2	CCHC NOA-type domain-containing protein. (337 aa)
	PTGIS	Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (500 aa)
	FN1	Fibronectin 1. (2477 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
	HYAL1	Hyaluronidase. (435 aa)
	ST18	ST18 C2H2C-type zinc finger transcription factor. (1038 aa)
	LOC108526721	SCY domain-containing protein. (114 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (596 aa)
	ENSRBIP00000006958	TNF receptor-associated factor. (473 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1079 aa)
	IL1RL2	Interleukin 1 receptor like 2. (652 aa)
	MYLK3	Myosin light chain kinase 3. (818 aa)
	CCL20	C-C motif chemokine. (96 aa)
	INHBB	Inhibin subunit beta B. (407 aa)
	IL1R1	Interleukin 1 receptor type 1. (568 aa)
	GBP2	Guanylate binding protein 2. (490 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
	CCL16	C-C motif chemokine. (120 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	ENSRBIP00000012634	RRM domain-containing protein. (343 aa)
	HAS2	Hyaluronan synthase 2. (552 aa)
	DAB2IP	DAB2 interacting protein. (1156 aa)
	HYAL3	Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Belongs to the glycosyl hydrolase 56 family. (417 aa)
	CCL21	C-C motif chemokine ligand 21. (131 aa)
	LOC108526722	SCY domain-containing protein. (114 aa)
	CCL1	C-C motif chemokine. (96 aa)
	SFRP1	Secreted frizzled related protein 1. (313 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	RELA	Uncharacterized protein. (282 aa)
	ACOD1	Aconitate decarboxylase 1. (458 aa)
	HYAL2	Hyaluronidase. (467 aa)
	CCL18	C-C motif chemokine. (66 aa)
	MMP2	Matrix metallopeptidase 2. (660 aa)
	TOLLIP	Toll interacting protein. (274 aa)
	CX3CL1	C-X3-C motif chemokine ligand 1. (407 aa)
	FGB	Fibrinogen beta chain. (491 aa)
	SIRPA	Uncharacterized protein. (505 aa)
	CCL22	C-C motif chemokine. (93 aa)
	TANK	TRAF family member associated NFKB activator. (425 aa)
	CCL23	C-C motif chemokine. (120 aa)
	IRAK1	Interleukin 1 receptor associated kinase 1. (702 aa)
	LOC108539397	SCY domain-containing protein. (112 aa)
	CCL13	C-C motif chemokine. (98 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1134 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
	ENSRBIP00000027860	RRM domain-containing protein. (357 aa)
	KLF2	Uncharacterized protein. (194 aa)
	LOC108541410	SCY domain-containing protein. (102 aa)
	CCL14	C-C motif chemokine. (92 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (537 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (802 aa)
	CCL19	C-C motif chemokine. (98 aa)
	CCL5	C-C motif chemokine. (91 aa)
	CCL24	C-C motif chemokine ligand 24. (111 aa)
	LOC108539097	C-C motif chemokine. (109 aa)
	CCL17	C-C motif chemokine. (91 aa)
	RPS6KA4	Ribosomal protein S6 kinase. (771 aa)
	MAPK13	Mitogen-activated protein kinase. (365 aa)
	CCL8	C-C motif chemokine. (99 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	NR1D1	Nuclear receptor subfamily 1 group D member 1. (613 aa)
	FGG	Fibrinogen gamma chain. (453 aa)
	KMO	Kynurenine 3-monooxygenase. (431 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (414 aa)
	RPS6KA5	Non-specific serine/threonine protein kinase. (684 aa)
	CCL26	C-C motif chemokine. (94 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (570 aa)
	ENSRBIP00000038500	RHD domain-containing protein. (112 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	IRAK4	Interleukin 1 receptor associated kinase 4. (461 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (842 aa)
	ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif 12. (1597 aa)
	IL17A	Interleukin 17A. (155 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL1	CCL16	ENSRBIP00000015940	ENSRBIP00000010359	C-C motif chemokine.	C-C motif chemokine.	0.414
CCL1	CCL17	ENSRBIP00000015940	ENSRBIP00000032757	C-C motif chemokine.	C-C motif chemokine.	0.633
CCL1	CCL20	ENSRBIP00000015940	ENSRBIP00000008004	C-C motif chemokine.	C-C motif chemokine.	0.493
CCL1	CCL21	ENSRBIP00000015940	ENSRBIP00000015130	C-C motif chemokine.	C-C motif chemokine ligand 21.	0.407
CCL1	CCL22	ENSRBIP00000015940	ENSRBIP00000024020	C-C motif chemokine.	C-C motif chemokine.	0.516
CCL1	CCL24	ENSRBIP00000015940	ENSRBIP00000031414	C-C motif chemokine.	C-C motif chemokine ligand 24.	0.442
CCL1	CCL5	ENSRBIP00000015940	ENSRBIP00000030686	C-C motif chemokine.	C-C motif chemokine.	0.690
CCL1	CX3CL1	ENSRBIP00000015940	ENSRBIP00000021483	C-C motif chemokine.	C-X3-C motif chemokine ligand 1.	0.521
CCL1	CXCL8	ENSRBIP00000015940	ENSRBIP00000006595	C-C motif chemokine.	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.685
CCL1	LOC108539397	ENSRBIP00000015940	ENSRBIP00000026638	C-C motif chemokine.	SCY domain-containing protein.	0.526
CCL1	LOC108541410	ENSRBIP00000015940	ENSRBIP00000028906	C-C motif chemokine.	SCY domain-containing protein.	0.480
CCL13	CCL21	ENSRBIP00000027696	ENSRBIP00000015130	C-C motif chemokine.	C-C motif chemokine ligand 21.	0.963
CCL13	CCL22	ENSRBIP00000027696	ENSRBIP00000024020	C-C motif chemokine.	C-C motif chemokine.	0.624
CCL13	CCL23	ENSRBIP00000027696	ENSRBIP00000026286	C-C motif chemokine.	C-C motif chemokine.	0.925
CCL13	CCL24	ENSRBIP00000027696	ENSRBIP00000031414	C-C motif chemokine.	C-C motif chemokine ligand 24.	0.995
CCL13	CCL26	ENSRBIP00000027696	ENSRBIP00000036845	C-C motif chemokine.	C-C motif chemokine.	0.994
CCL13	CCL5	ENSRBIP00000027696	ENSRBIP00000030686	C-C motif chemokine.	C-C motif chemokine.	0.996
CCL13	CCL8	ENSRBIP00000027696	ENSRBIP00000033499	C-C motif chemokine.	C-C motif chemokine.	0.996
CCL13	CXCL8	ENSRBIP00000027696	ENSRBIP00000006595	C-C motif chemokine.	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.480
CCL13	IL1B	ENSRBIP00000027696	ENSRBIP00000017788	C-C motif chemokine.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.431