(19 nodes) Collecting duct development network (Rhinopithecus bieti)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NOTCH1	Notch receptor 1. (2438 aa)
	UMOD	Uromodulin. (690 aa)
	ENSRBIP00000016589	Uncharacterized protein. (267 aa)
	PTCH1	Patched 1. (1455 aa)
	DLG5	Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1919 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
	AKR1B1	Aldo-keto reductase family 1 member B. (316 aa)
	PAX2	Paired box 2. (242 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4129 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	ENSRBIP00000035533	Aldo_ket_red domain-containing protein. (261 aa)
	WNT7B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	ENSRBIP00000035121	Uncharacterized protein. (276 aa)
	AQP2	Aquaporin 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	TFAP2B	Transcription factor AP-2 beta. (442 aa)
	ENSRBIP00000031182	Uncharacterized protein. (276 aa)
	ENSRBIP00000028771	Aldo_ket_red domain-containing protein. (290 aa)
	CALB1	Calbindin 1. (261 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQP2	UMOD	ENSRBIP00000033441	ENSRBIP00000019106	Aquaporin 2; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uromodulin.	0.726
BMP4	PTCH1	ENSRBIP00000039189	ENSRBIP00000012674	Bone morphogenetic protein 4.	Patched 1.	0.423
BMP4	SHH	ENSRBIP00000039189	ENSRBIP00000011175	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.595
NOTCH1	SHH	ENSRBIP00000022251	ENSRBIP00000011175	Notch receptor 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.421
PTCH1	BMP4	ENSRBIP00000012674	ENSRBIP00000039189	Patched 1.	Bone morphogenetic protein 4.	0.423
PTCH1	SHH	ENSRBIP00000012674	ENSRBIP00000011175	Patched 1.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.998
SHH	BMP4	ENSRBIP00000011175	ENSRBIP00000039189	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Bone morphogenetic protein 4.	0.595
SHH	NOTCH1	ENSRBIP00000011175	ENSRBIP00000022251	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Notch receptor 1.	0.421
SHH	PTCH1	ENSRBIP00000011175	ENSRBIP00000012674	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	Patched 1.	0.998
UMOD	AQP2	ENSRBIP00000019106	ENSRBIP00000033441	Uromodulin.	Aquaporin 2; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.726
WNT7B	WNT9B	ENSRBIP00000033773	ENSRBIP00000027103	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.424
WNT9B	WNT7B	ENSRBIP00000027103	ENSRBIP00000033773	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.424