(65 nodes) Nephron epithelium morphogenesis network (Rhinopithecus bieti)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP2	Bone morphogenetic protein 2. (321 aa)
	AHI1	Abelson helper integration site 1. (1195 aa)
	IRX1	Iroquois homeobox 1. (466 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (331 aa)
	HOXA11	Homeobox A11. (313 aa)
	COMMD5	COMM domain containing 5. (224 aa)
	WNT6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (81 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4129 aa)
	SALL1	Spalt like transcription factor 1. (1224 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (231 aa)
	LOC108542978	COMM domain-containing protein. (181 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
	LAMA5	Laminin subunit alpha 5. (3606 aa)
	IRX3	Iroquois homeobox 3. (502 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (861 aa)
	PAX2	Paired box 2. (242 aa)
	LOC108522363	Peptidase M12B domain-containing protein. (570 aa)
	SOX9	SRY-box transcription factor 9. (305 aa)
	GZF1	GDNF inducible zinc finger protein 1. (719 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (427 aa)
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1967 aa)
	LZTS2	Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
	TACSTD2	Tumor associated calcium signal transducer 2. (324 aa)
	GDNF	Glial cell derived neurotrophic factor. (228 aa)
	PTCH1	Patched 1. (1455 aa)
	TMEM59L	Transmembrane protein 59 like. (341 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (357 aa)
	GATA3	GATA binding protein 3. (444 aa)
	IRX2	Iroquois homeobox 2. (446 aa)
	DCHS1	Dachsous cadherin-related 1. (3295 aa)
	PGF	Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
	ENSRBIP00000016589	Uncharacterized protein. (267 aa)
	TCF21	Transcription factor 21. (179 aa)
	WNK4	WNK lysine deficient protein kinase 4. (1243 aa)
	ENSRBIP00000018476	Sulfotransferase; Belongs to the sulfotransferase 1 family. (253 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
	ENSRBIP00000022621	Homeobox domain-containing protein. (144 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	DSPP	Dentin sialophosphoprotein. (1310 aa)
	HES5	Hes family bHLH transcription factor 5. (152 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	KIF26B	Kinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1767 aa)
	GLI3	GLI family zinc finger 3. (1555 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	OSR1	Odd-skipped related transcription factor 1. (266 aa)
	WT1	WT1 transcription factor. (515 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
	KLHL3	Kelch like family member 3. (593 aa)
	SOX8	SRY-box transcription factor 8. (429 aa)
	FMN1	Formin 1. (1256 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	SIX2	SIX homeobox 2. (292 aa)
	PBX1	PBX homeobox 1. (465 aa)
	GREB1	Growth regulating estrogen receptor binding 1. (1949 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (931 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	SIX1	SIX homeobox 1. (284 aa)
	HS2ST1	Heparan sulfate 2-O-sulfotransferase 1. (356 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (958 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	CTNNB1	ENSRBIP00000010712	ENSRBIP00000022705	BCL2 apoptosis regulator.	Catenin beta 1.	0.484
BMP2	BMP4	ENSRBIP00000043407	ENSRBIP00000039189	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.413
BMP2	CTNNB1	ENSRBIP00000043407	ENSRBIP00000022705	Bone morphogenetic protein 2.	Catenin beta 1.	0.418
BMP2	FGF2	ENSRBIP00000043407	ENSRBIP00000030754	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.584
BMP2	FGF8	ENSRBIP00000043407	ENSRBIP00000028522	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.478
BMP2	NOG	ENSRBIP00000043407	ENSRBIP00000003551	Bone morphogenetic protein 2.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.535
BMP2	PTCH1	ENSRBIP00000043407	ENSRBIP00000012674	Bone morphogenetic protein 2.	Patched 1.	0.423
BMP2	SHH	ENSRBIP00000043407	ENSRBIP00000011175	Bone morphogenetic protein 2.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.438
BMP2	SMAD4	ENSRBIP00000043407	ENSRBIP00000018874	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.851
BMP2	SOX9	ENSRBIP00000043407	ENSRBIP00000009330	Bone morphogenetic protein 2.	SRY-box transcription factor 9.	0.438
BMP4	BMP2	ENSRBIP00000039189	ENSRBIP00000043407	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.413
BMP4	CTNNB1	ENSRBIP00000039189	ENSRBIP00000022705	Bone morphogenetic protein 4.	Catenin beta 1.	0.420
BMP4	FGF2	ENSRBIP00000039189	ENSRBIP00000030754	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.564
BMP4	FGF8	ENSRBIP00000039189	ENSRBIP00000028522	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.549
BMP4	NOG	ENSRBIP00000039189	ENSRBIP00000003551	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.951
BMP4	PTCH1	ENSRBIP00000039189	ENSRBIP00000012674	Bone morphogenetic protein 4.	Patched 1.	0.423
BMP4	SHH	ENSRBIP00000039189	ENSRBIP00000011175	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.595
BMP4	SMAD4	ENSRBIP00000039189	ENSRBIP00000018874	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.869
CITED1	SIX2	ENSRBIP00000021317	ENSRBIP00000035559	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1.	SIX homeobox 2.	0.455
CTNNB1	BCL2	ENSRBIP00000022705	ENSRBIP00000010712	Catenin beta 1.	BCL2 apoptosis regulator.	0.484