STRINGSTRING
MCU MCU G6PC2 G6PC2 ICA1 ICA1 SLC8B1 SLC8B1 SIRT6 SIRT6 SLC16A1 SLC16A1 MIDN MIDN FFAR1 FFAR1 NNAT NNAT IRS1 IRS1 REST REST HNF1A HNF1A GPER1 GPER1 BAIAP3 BAIAP3 ENSRBIP00000015369 ENSRBIP00000015369 GRP GRP ALOX5 ALOX5 IRS2 IRS2 SFRP1 SFRP1 AIMP1 AIMP1 FOXA2 FOXA2 SIRT4 SIRT4 ENSRBIP00000009767 ENSRBIP00000009767 PER2 PER2 GHSR GHSR INHBB INHBB CDV3 CDV3 ABCC8 ABCC8 ENSA ENSA DRD2 DRD2 PRKN PRKN FFAR2 FFAR2 TM7SF3 TM7SF3 ISL1 ISL1 GPR68 GPR68 CASR CASR FOXO1 FOXO1 ENSRBIP00000006344 ENSRBIP00000006344 MYRIP MYRIP PFKL PFKL SYT7 SYT7 NEUROD1 NEUROD1 SELENOT SELENOT KCNA5 KCNA5 KCNJ11 KCNJ11 SYT9 SYT9 PPP3CA-2 PPP3CA-2 ANO1 ANO1 ENSRBIP00000002993 ENSRBIP00000002993 STXBP4 STXBP4 TUNAR TUNAR PPP3CB PPP3CB PPP3CA PPP3CA ENSRBIP00000002079 ENSRBIP00000002079 SOX4 SOX4 CPT1A CPT1A CARTPT CARTPT ENSRBIP00000001234 ENSRBIP00000001234 TCF7L2 TCF7L2 CRH CRH HADH HADH SREBF1 SREBF1 ENSRBIP00000016878 ENSRBIP00000016878 RFX3 RFX3 HFE HFE SCT SCT ARNTL ARNTL ECRG4 ECRG4 IL1B IL1B RBP4 RBP4 NR1H4 NR1H4 CAPN10 CAPN10 CDK16 CDK16 ADCYAP1 ADCYAP1 PAX8 PAX8 SLC25A22 SLC25A22 SPINK1 SPINK1 C1QTNF12 C1QTNF12 PASK PASK CCN3 CCN3 CHGA CHGA GHRHR GHRHR TRH TRH RAB8B RAB8B GCK GCK FGB FGB SSTR5 SSTR5 ENSRBIP00000022449 ENSRBIP00000022449 EFNA5 EFNA5 KCNB1 KCNB1 HMGN3 HMGN3 ADCY8 ADCY8 FFAR4 FFAR4 MPC2 MPC2 GPLD1 GPLD1 ARHGEF7 ARHGEF7 HNF4A HNF4A LRRC8A LRRC8A TNFSF11 TNFSF11 TCIRG1 TCIRG1 ENSRBIP00000026419 ENSRBIP00000026419 LOC108525236 LOC108525236 PTPN11 PTPN11 BIRC5 BIRC5 GCG GCG NR0B2 NR0B2 CFTR CFTR TRPM4 TRPM4 SYTL4 SYTL4 RASL10B RASL10B FAM3D FAM3D GHRL GHRL BRSK2 BRSK2 PFKM PFKM CCL5 CCL5 RPH3AL RPH3AL PDX1 PDX1 LOC108528963 LOC108528963 NLGN2 NLGN2 CRHBP CRHBP EIPR1 EIPR1 IFNG IFNG STX4 STX4 TFR2 TFR2 GIP GIP GABBR1 GABBR1 ILDR1 ILDR1 ENSRBIP00000032719 ENSRBIP00000032719 C2CD2L C2CD2L DOC2B DOC2B TFAP2B TFAP2B FKBP1B FKBP1B ADCY5 ADCY5 KLF7 KLF7 PSMD9 PSMD9 NR1D1 NR1D1 FGG FGG STXBP5L STXBP5L CLOCK CLOCK PCK2 PCK2 ACVR1C ACVR1C NDUFAF2 NDUFAF2 ENSRBIP00000035558 ENSRBIP00000035558 SLC30A8 SLC30A8 PPARD PPARD MTNR1B MTNR1B SRI SRI SIDT2 SIDT2 SLC9B2 SLC9B2 TRPM2 TRPM2 ABAT ABAT PICK1 PICK1 GHRH GHRH HIF1A HIF1A PLA2G6 PLA2G6 VSNL1 VSNL1 ABCA12 ABCA12 CHD7 CHD7 PRKCE PRKCE EPHA5 EPHA5 LEP LEP FGA FGA IL6 IL6 GIPR GIPR BAD BAD BLK BLK RFX6 RFX6 LRP5L LRP5L KALRN KALRN OSBP OSBP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCUMitochondrial calcium uniporter. (351 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
ICA1Islet cell autoantigen 1. (512 aa)
SLC8B1Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (583 aa)
SIRT6Sirtuin 6. (355 aa)
SLC16A1Solute carrier family 16 member 1. (500 aa)
MIDNMidnolin. (385 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
NNATNeuronatin. (80 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
RESTRE1 silencing transcription factor. (1080 aa)
HNF1AHNF1 homeobox A. (662 aa)
GPER1G protein-coupled estrogen receptor 1. (373 aa)
BAIAP3BAI1 associated protein 3. (1186 aa)
ENSRBIP00000015369Uncharacterized protein. (89 aa)
GRPGastrin releasing peptide. (142 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
IRS2Insulin receptor substrate 2. (904 aa)
SFRP1Secreted frizzled related protein 1. (313 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (321 aa)
FOXA2Forkhead box A2. (463 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
ENSRBIP00000009767Uncharacterized protein. (546 aa)
PER2Period circadian regulator 2. (1311 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
INHBBInhibin subunit beta B. (407 aa)
CDV3CDV3 homolog. (244 aa)
ABCC8ATP binding cassette subfamily C member 8. (1585 aa)
ENSAUncharacterized protein. (136 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
FFAR2Free fatty acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (330 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
ISL1ISL LIM homeobox 1. (349 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CASRCalcium sensing receptor. (1078 aa)
FOXO1Forkhead box O1. (539 aa)
ENSRBIP00000006344C2H2-type domain-containing protein. (250 aa)
MYRIPMyosin VIIA and Rab interacting protein. (859 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (774 aa)
SYT7Synaptotagmin 7. (672 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (189 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
SYT9Synaptotagmin 9. (442 aa)
PPP3CA-2Uncharacterized protein. (70 aa)
ANO1Anoctamin. (962 aa)
ENSRBIP00000002993Uncharacterized protein. (237 aa)
STXBP4Syntaxin binding protein 4. (322 aa)
TUNARTCL1 upstream neural differentiation-associated RNA. (48 aa)
PPP3CBSerine/threonine-protein phosphatase. (524 aa)
PPP3CASerine/threonine-protein phosphatase. (310 aa)
ENSRBIP00000002079Uncharacterized protein. (202 aa)
SOX4Transcription factor SOX. (475 aa)
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (762 aa)
CARTPTCART prepropeptide. (116 aa)
ENSRBIP00000001234Uncharacterized protein. (93 aa)
TCF7L2HMG box domain-containing protein. (376 aa)
CRHCorticotropin releasing hormone. (196 aa)
HADHHydroxyacyl-CoA dehydrogenase. (341 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1047 aa)
ENSRBIP00000016878Uncharacterized protein. (251 aa)
RFX3Regulatory factor X3. (668 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
SCTSecretin. (101 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (594 aa)
ECRG4ECRG4 augurin precursor. (148 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (201 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (481 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (672 aa)
CDK16Cyclin dependent kinase 16. (570 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
PAX8Paired box 8. (484 aa)
SLC25A22Solute carrier family 25 member 22; Belongs to the mitochondrial carrier (TC 2.A.29) family. (323 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
C1QTNF12C1q and TNF related 12. (278 aa)
PASKPAS domain containing serine/threonine kinase. (1321 aa)
CCN3Cellular communication network factor 3. (357 aa)
CHGAChromogranin A. (510 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (242 aa)
RAB8BRAB8B, member RAS oncogene family. (207 aa)
GCKPhosphotransferase. (466 aa)
FGBFibrinogen beta chain. (491 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ENSRBIP00000022449Uncharacterized protein. (254 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
HMGN3High mobility group nucleosomal binding domain 3. (117 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
FFAR4Free fatty acid receptor 4. (377 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (847 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (755 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (317 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
ENSRBIP00000026419Uncharacterized protein. (249 aa)
LOC108525236Uncharacterized protein. (137 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
GCGGlucagon. (180 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1052 aa)
SYTL4Synaptotagmin like 4. (672 aa)
RASL10BRAS like family 10 member B. (203 aa)
FAM3DFamily with sequence similarity 3 member D. (224 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
BRSK2BR serine/threonine kinase 2. (756 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
CCL5C-C motif chemokine. (91 aa)
RPH3ALRabphilin 3A like (without C2 domains). (311 aa)
PDX1Pancreatic and duodenal homeobox 1. (284 aa)
LOC108528963ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
NLGN2Neuroligin 2. (698 aa)
CRHBPCorticotropin releasing hormone binding protein. (275 aa)
EIPR1EARP complex and GARP complex interacting protein 1. (387 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (159 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (297 aa)
TFR2Transferrin receptor 2. (643 aa)
GIPGastric inhibitory polypeptide. (151 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (1046 aa)
ILDR1Immunoglobulin like domain containing receptor 1. (546 aa)
ENSRBIP00000032719SH2 domain-containing protein. (203 aa)
C2CD2LC2CD2 like. (707 aa)
DOC2BDouble C2-like domain-containing protein. (406 aa)
TFAP2BTranscription factor AP-2 beta. (442 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
KLF7Kruppel like factor 7. (302 aa)
PSMD9PDZ domain-containing protein. (223 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
FGGFibrinogen gamma chain. (453 aa)
STXBP5LSyntaxin binding protein 5 like. (1180 aa)
CLOCKClock circadian regulator. (847 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (413 aa)
NDUFAF2NADH:ubiquinone oxidoreductase complex assembly factor 2. (111 aa)
ENSRBIP00000035558Uncharacterized protein. (101 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (362 aa)
SRISorcin. (198 aa)
SIDT2SID1 transmembrane family member 2. (855 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1552 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (506 aa)
PICK1Protein interacting with PRKCA 1. (415 aa)
GHRHGrowth hormone releasing hormone. (107 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (842 aa)
PLA2G6Phospholipase A2 group VI. (806 aa)
VSNL1Visinin like 1. (191 aa)
ABCA12ATP binding cassette subfamily A member 12. (2595 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2986 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
EPHA5EPH receptor A5. (1038 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
FGAFibrinogen alpha chain. (906 aa)
IL6Interleukin 6. (214 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (466 aa)
BADBCL2 associated agonist of cell death. (167 aa)
BLKTyrosine-protein kinase. (505 aa)
RFX6Regulatory factor X6. (916 aa)
LRP5LLDL receptor related protein 5 like. (251 aa)
KALRNKalirin RhoGEF kinase. (2940 aa)
OSBPOxysterol-binding protein; Belongs to the OSBP family. (791 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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