68 items (Rhinopithecus bieti) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ECRG4	ECRG4 augurin precursor. (148 aa)
	MAP2K3	Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
	CDKN2A	Uncharacterized protein. (173 aa)
	TBX3	T-box transcription factor 3. (743 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa)
	MAP2K6	Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
	HRAS	HRas proto-oncogene, GTPase. (189 aa)
	KAT6A	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (1703 aa)
	DNAJA3	DnaJ heat shock protein family (Hsp40) member A3. (480 aa)
	TBX2	T-box transcription factor 2. (686 aa)
	PRKCD	Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (676 aa)
	ENSRBIP00000023060	Protein kinase domain-containing protein. (120 aa)
	WNT16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
	CALR	Calreticulin. (417 aa)
	TERF2	Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (421 aa)
	MAP3K5	Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
	PRELP	Proline and arginine rich end leucine rich repeat protein. (382 aa)
	SRF	Serum response factor. (508 aa)
	BRCA2	Uncharacterized protein. (386 aa)
	PLA2R1	Phospholipase A2 receptor 1. (1445 aa)
	NSMCE2	SP-RING-type domain-containing protein. (246 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	PRMT6	Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (375 aa)
	MAPK10	Mitogen-activated protein kinase. (528 aa)
	LOC108525824	Uncharacterized protein. (121 aa)
	ENSRBIP00000005272	Uncharacterized protein. (264 aa)
	MAPK9	Mitogen-activated protein kinase. (407 aa)
	ENSRBIP00000007206	Nucleoplasmin domain-containing protein. (251 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (140 aa)
	SIRT1	Sirtuin 1. (731 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	ENSRBIP00000010478	SP-RING-type domain-containing protein. (216 aa)
	HMGA1	Uncharacterized protein. (201 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (253 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1073 aa)
	ENSRBIP00000013303	Uncharacterized protein. (138 aa)
	MAP2K1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
	ENSRBIP00000015186	Uncharacterized protein. (279 aa)
	WRN	WRN RecQ like helicase. (1394 aa)
	ENSRBIP00000015568	Uncharacterized protein. (258 aa)
	SMC6	Structural maintenance of chromosomes 6. (1040 aa)
	ENSRBIP00000016494	Protein kinase domain-containing protein. (253 aa)
	ULK3	Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (472 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator like. (594 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (408 aa)
	SMC5	Structural maintenance of chromosomes 5. (1054 aa)
	HMGA2	High mobility group AT-hook 2. (147 aa)
	MAPK8	Mitogen-activated protein kinase 8. (383 aa)
	ENSRBIP00000031480	Uncharacterized protein. (297 aa)
	MIF	Uncharacterized protein. (115 aa)
	LOC108523445	Uncharacterized protein. (106 aa)
	MAPKAPK5	MAPK activated protein kinase 5. (471 aa)
	MAPK11	Mitogen-activated protein kinase. (364 aa)
	PML	Promyelocytic leukemia. (932 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (728 aa)
	MAP2K7	Mitogen-activated protein kinase kinase 7. (414 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa)
	NPM1	Nucleophosmin 1. (294 aa)
	NUP62	Nucleoporin 62. (442 aa)
	OPA1	OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1018 aa)
	ENSRBIP00000041126	Uncharacterized protein. (322 aa)
	MNT	MAX network transcriptional repressor. (541 aa)
	ENSRBIP00000043094	Uncharacterized protein. (97 aa)
	ID2	Inhibitor of DNA binding 2. (134 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1335 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ATM	ENSRBIP00000007933	ENSRBIP00000020338	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.899
ABL1	CDKN1A	ENSRBIP00000007933	ENSRBIP00000008800	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1A.	0.575
ABL1	CDKN1B	ENSRBIP00000007933	ENSRBIP00000000920	Tyrosine-protein kinase.	Cyclin dependent kinase inhibitor 1B.	0.432
ABL1	HRAS	ENSRBIP00000007933	ENSRBIP00000021775	Tyrosine-protein kinase.	HRas proto-oncogene, GTPase.	0.476
ABL1	MAPK11	ENSRBIP00000007933	ENSRBIP00000034454	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.423
ABL1	MAPK14	ENSRBIP00000007933	ENSRBIP00000027919	Tyrosine-protein kinase.	Mitogen-activated protein kinase.	0.432
ABL1	TP53	ENSRBIP00000007933	ENSRBIP00000028632	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.631
ARNTL	SIRT1	ENSRBIP00000017529	ENSRBIP00000010135	Aryl hydrocarbon receptor nuclear translocator like.	Sirtuin 1.	0.804
ATM	ABL1	ENSRBIP00000020338	ENSRBIP00000007933	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.899
ATM	BRCA2	ENSRBIP00000020338	ENSRBIP00000000297	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.903
ATM	CDK2	ENSRBIP00000020338	ENSRBIP00000036901	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.811
ATM	CDKN1A	ENSRBIP00000020338	ENSRBIP00000008800	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin dependent kinase inhibitor 1A.	0.440
ATM	CDKN2A	ENSRBIP00000020338	ENSRBIP00000018374	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.436
ATM	KAT6A	ENSRBIP00000020338	ENSRBIP00000021921	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.591
ATM	LOC108525824	ENSRBIP00000020338	ENSRBIP00000004085	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.591
ATM	MAPK10	ENSRBIP00000020338	ENSRBIP00000003315	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase.	0.521
ATM	MAPK8	ENSRBIP00000020338	ENSRBIP00000031476	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase 8.	0.537
ATM	MAPK9	ENSRBIP00000020338	ENSRBIP00000007051	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Mitogen-activated protein kinase.	0.407
ATM	SIRT1	ENSRBIP00000020338	ENSRBIP00000010135	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Sirtuin 1.	0.598
ATM	SMC5	ENSRBIP00000020338	ENSRBIP00000031393	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Structural maintenance of chromosomes 5.	0.588