(92 nodes) Cellular response to alcohol network (Rhinopithecus bieti)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	P2RY6	Pyrimidinergic receptor P2Y6. (290 aa)
	P2RY4	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (365 aa)
	FN1	Fibronectin 1. (2477 aa)
	PTGFR	Prostaglandin F receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
	GOLPH3	Golgi phosphoprotein 3. (298 aa)
	SCNN1B	Sodium channel epithelial 1 beta subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (696 aa)
	PTGDR	Prostaglandin D2 receptor. (359 aa)
	AIFM1	Apoptosis inducing factor mitochondria associated 1. (598 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
	ENSRBIP00000004795	DUF4502 domain-containing protein. (197 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
	ENSRBIP00000007485	Biotin carboxylation domain-containing protein. (156 aa)
	SLC23A2	Solute carrier family 23 member 2. (650 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	AKR1C3	Aldo-keto reductase family 1 member C3. (343 aa)
	INHBB	Inhibin subunit beta B. (407 aa)
	AKT1	AKT serine/threonine kinase 1. (486 aa)
	ENSRBIP00000010915	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (307 aa)
	BLM	BLM RecQ like helicase. (1396 aa)
	DAG1	Dystroglycan 1. (893 aa)
	AKAP8	A-kinase anchoring protein 8; Belongs to the AKAP95 family. (646 aa)
	PTCH1	Patched 1. (1455 aa)
	ENSRBIP00000014055	RL10P_insert domain-containing protein. (320 aa)
	KCNMB1	Potassium calcium-activated channel subfamily M regulatory beta subunit 1. (191 aa)
	CYP7A1	Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family. (405 aa)
	HNF1A	HNF1 homeobox A. (662 aa)
	DNMT3A	DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
	CDH1	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins. (924 aa)
	GLRA1	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
	PTRHD1	Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
	SFRP1	Secreted frizzled related protein 1. (313 aa)
	ATP2B1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1071 aa)
	GRAMD1C	GRAM domain containing 1C. (617 aa)
	JUP	Junction plakoglobin. (709 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
	SPIDR	DUF4503 domain-containing protein. (397 aa)
	TNFSF4	TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
	DYNAP	Dynactin associated protein. (165 aa)
	ENSRBIP00000019984	RL10P_insert domain-containing protein. (318 aa)
	LOC108532992	Aldo-keto reductase family 1 member C1. (303 aa)
	GRAMD1B	GRAM domain containing 1B. (877 aa)
	INHBA	Inhibin subunit beta A. (426 aa)
	NFE2L1	Nuclear factor, erythroid 2 like 1. (772 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (102 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2637 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (228 aa)
	GRAMD1A	GRAM domain containing 1A. (814 aa)
	ADCY8	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (847 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
	SPHK2	Sphingosine kinase 2. (658 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (574 aa)
	CYBB	Cytochrome b-245 beta chain. (513 aa)
	TP53INP1	Tumor protein p53 inducible nuclear protein 1. (241 aa)
	ADAM15	ADAM metallopeptidase domain 15. (865 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
	LARP1	La ribonucleoprotein domain family member 1. (1034 aa)
	KLF2	Uncharacterized protein. (194 aa)
	ENSRBIP00000029827	Uncharacterized protein. (106 aa)
	ENSRBIP00000031080	Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (191 aa)
	RAD51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa)
	FDX1	Ferredoxin 1. (184 aa)
	ENSRBIP00000032920	RL10P_insert domain-containing protein. (190 aa)
	ENSRBIP00000033767	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (320 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
	RPLP0	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (318 aa)
	MAP4K1	Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (819 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
	XRN1	5'-3' exoribonuclease 1. (1705 aa)
	LRP8	LDL receptor related protein 8. (972 aa)
	GNAS	GNAS complex locus. (1041 aa)
	OSBPL7	Oxysterol-binding protein; Belongs to the OSBP family. (842 aa)
	UCP1	Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
	NPAS4	Neuronal PAS domain protein 4. (802 aa)
	LOC108532991	Aldo_ket_red domain-containing protein. (323 aa)
	SCNN1G	Sodium channel epithelial 1 gamma subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (690 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (539 aa)
	PRKCE	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
	CTNNA1	Catenin alpha 1. (906 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1818 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (786 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1335 aa)
	PTGER2	Prostaglandin E receptor 2; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	ENSRBIP00000042758	Uncharacterized protein. (1677 aa)
	ENSRBIP00000042139	Uncharacterized protein. (108 aa)
	ENSRBIP00000000157	Uncharacterized protein. (249 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM15	CDH1	ENSRBIP00000027409	ENSRBIP00000015814	ADAM metallopeptidase domain 15.	Cadherin 1; Cadherins are calcium-dependent cell adhesion proteins.	0.562
ADCY1	ADCY2	ENSRBIP00000035296	ENSRBIP00000024365	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.458
ADCY1	ADCY3	ENSRBIP00000035296	ENSRBIP00000021747	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.944
ADCY1	ADCY5	ENSRBIP00000035296	ENSRBIP00000034265	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.429
ADCY1	ADCY6	ENSRBIP00000035296	ENSRBIP00000004607	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.429
ADCY1	ADCY7	ENSRBIP00000035296	ENSRBIP00000016019	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.488
ADCY1	ADCY8	ENSRBIP00000035296	ENSRBIP00000023627	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.957
ADCY1	GNAS	ENSRBIP00000035296	ENSRBIP00000036792	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.970
ADCY1	GNG2	ENSRBIP00000035296	ENSRBIP00000022343	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.827
ADCY1	PTRHD1	ENSRBIP00000035296	ENSRBIP00000016259	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Peptidyl-tRNA hydrolase domain containing 1.	0.465
ADCY2	ADCY1	ENSRBIP00000024365	ENSRBIP00000035296	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.458
ADCY2	ADCY5	ENSRBIP00000024365	ENSRBIP00000034265	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.778
ADCY2	ADCY6	ENSRBIP00000024365	ENSRBIP00000004607	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.772
ADCY2	ADCY7	ENSRBIP00000024365	ENSRBIP00000016019	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.416
ADCY2	ADCY8	ENSRBIP00000024365	ENSRBIP00000023627	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.450
ADCY2	GNAS	ENSRBIP00000024365	ENSRBIP00000036792	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	GNAS complex locus.	0.979
ADCY2	GNG2	ENSRBIP00000024365	ENSRBIP00000022343	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.772
ADCY3	ADCY1	ENSRBIP00000021747	ENSRBIP00000035296	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.944
ADCY3	ADCY6	ENSRBIP00000021747	ENSRBIP00000004607	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.936
ADCY3	ADCY8	ENSRBIP00000021747	ENSRBIP00000023627	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.949