STRINGSTRING
C17orf64 C17orf64 DDX11 DDX11 ENSRBIP00000034301 ENSRBIP00000034301 POLB POLB MUS81 MUS81 SETX SETX RFC1 RFC1 UNG UNG DNMT3B DNMT3B LOC108523445 LOC108523445 ALKBH4 ALKBH4 SMARCAL1 SMARCAL1 LIG4 LIG4 ZRANB3 ZRANB3 XRCC6 XRCC6 RAD51 RAD51 HMGA2 HMGA2 PMS2 PMS2 XRCC2 XRCC2 CHD8 CHD8 ARID3A ARID3A HELB HELB DNASE2 DNASE2 SMARCA4 SMARCA4 SMARCA2 SMARCA2 PRIMPOL PRIMPOL ZGRF1 ZGRF1 RTEL1 RTEL1 MPG MPG ENSRBIP00000000510 ENSRBIP00000000510 NEIL1 NEIL1 MSH3 MSH3 TOP1MT TOP1MT RAD51D RAD51D POLN POLN ENSRBIP00000001755 ENSRBIP00000001755 RECQL5 RECQL5 FANCM FANCM ENSRBIP00000002430 ENSRBIP00000002430 RPS3 RPS3 MYO18A MYO18A RBBP8 RBBP8 SMARCA5 SMARCA5 DHX36 DHX36 MGME1 MGME1 CHD1 CHD1 DNTT DNTT IGHMBP2 IGHMBP2 EP400 EP400 ENSRBIP00000041364 ENSRBIP00000041364 SELENOV SELENOV LIG1 LIG1 DMC1 DMC1 CHD7 CHD7 RAD17 RAD17 RAD54L RAD54L DNASE1L2 DNASE1L2 RSF1 RSF1 MSH4 MSH4 UPF1 UPF1 FEN1 FEN1 ENSRBIP00000003378 ENSRBIP00000003378 HLTF HLTF MCM8 MCM8 ERCC6L2 ERCC6L2 MSH6 MSH6 DICER1 DICER1 GTF2F2 GTF2F2 NEIL3 NEIL3 POLQ POLQ TOP2B TOP2B BRIP1 BRIP1 MGMT MGMT DNASE2B DNASE2B N6AMT1 N6AMT1 ENDOG ENDOG PLD4 PLD4 ALKBH1 ALKBH1 OGG1 OGG1 SHPRH SHPRH PCNA PCNA MLH1 MLH1 BTAF1 BTAF1 MUTYH MUTYH MSH5 MSH5 ERCC3 ERCC3 MBD4 MBD4 MCM9 MCM9 PGBD5 PGBD5 TOP2A TOP2A DFFB DFFB CECR2 CECR2 TM4SF19 TM4SF19 POLH POLH DKC1 DKC1 ENSRBIP00000009490 ENSRBIP00000009490 ENSRBIP00000009858 ENSRBIP00000009858 ATAD5 ATAD5 TOP1 TOP1 EXOG EXOG LIG3 LIG3 CDK7 CDK7 DNASE1L3 DNASE1L3 ENSRBIP00000011182 ENSRBIP00000011182 ENSRBIP00000011440 ENSRBIP00000011440 SMUG1 SMUG1 BLM BLM ENSRBIP00000012004 ENSRBIP00000012004 HMGA1 HMGA1 DNASE1L1 DNASE1L1 MEIOB MEIOB WRNIP1 WRNIP1 ENSRBIP00000013167 ENSRBIP00000013167 ENSRBIP00000013303 ENSRBIP00000013303 ENSRBIP00000013617 ENSRBIP00000013617 EXD2 EXD2 TOP3A TOP3A TEP1 TEP1 SETMAR SETMAR MSH2 MSH2 TDG TDG XRCC3 XRCC3 ERCC4 ERCC4 MLH3 MLH3 ERCC2 ERCC2 PLD3 PLD3 SUPV3L1 SUPV3L1 DNMT1-2 DNMT1-2 SPO11 SPO11 RAD51C RAD51C DNMT3A DNMT3A ANKLE1 ANKLE1 WRN WRN INO80 INO80 TATDN1 TATDN1 SMC6 SMC6 CHD5 CHD5 TERT TERT RAD9A RAD9A RAD54L2 RAD54L2 TDP1 TDP1 DCLRE1B DCLRE1B POLD1 POLD1 MCM7 MCM7 DCLRE1A DCLRE1A PIF1 PIF1 ENSRBIP00000017801 ENSRBIP00000017801 XRCC5 XRCC5 POLI POLI LOC108525261 LOC108525261 RUVBL1 RUVBL1 RECQL4 RECQL4 ENSRBIP00000019290 ENSRBIP00000019290 CHD3 CHD3 ENSRBIP00000019555 ENSRBIP00000019555 HFM1 HFM1 ENSRBIP00000019958 ENSRBIP00000019958 FAN1 FAN1 DNASE1 DNASE1 GEN1 GEN1 ALKBH3 ALKBH3 ENSRBIP00000020474 ENSRBIP00000020474 MCM2 MCM2 MRE11 MRE11 POLL POLL RECQL RECQL POLE POLE TOP3B TOP3B NAV2 NAV2 SLX1A SLX1A PMS1 PMS1 ERCC6 ERCC6 RUVBL2 RUVBL2 ENSRBIP00000022922 ENSRBIP00000022922 MCM5 MCM5 C11orf80 C11orf80 CHD9 CHD9 ENSRBIP00000023338 ENSRBIP00000023338 RAD9B RAD9B APLF APLF SRCAP SRCAP ENSRBIP00000024049 ENSRBIP00000024049 RAD51B RAD51B SMARCA1 SMARCA1 RAD1 RAD1 POLG2 POLG2 MCM3 MCM3 APEX2 APEX2 POLD4 POLD4 POLE4 POLE4 ERCC6L ERCC6L EXO1 EXO1 CHD2 CHD2 POLE2 POLE2 METTL4 METTL4 TDP2 TDP2 HAUS3 HAUS3 POLK POLK CHD6 CHD6 ENSRBIP00000027300 ENSRBIP00000027300 ENSRBIP00000027339 ENSRBIP00000027339 MCM4 MCM4 REXO2 REXO2 DNMT1 DNMT1 FBH1 FBH1 APEX1 APEX1 LOC108520834 LOC108520834 ENSRBIP00000029216 ENSRBIP00000029216 MCM6 MCM6 MPHOSPH9 MPHOSPH9 RFC3 RFC3 APTX APTX TENT4B TENT4B TWNK TWNK NEIL2 NEIL2 CEP41 CEP41 CHRAC1 CHRAC1 TTF2 TTF2 NTHL1 NTHL1 ENDOV ENDOV ASCC3 ASCC3 ALKBH2 ALKBH2 G3BP1 G3BP1 ENSRBIP00000037360 ENSRBIP00000037360 POLM POLM ENSRBIP00000037149 ENSRBIP00000037149 DDX1 DDX1 ENSRBIP00000036862 ENSRBIP00000036862 SMARCAD1 SMARCAD1 DQX1 DQX1 HELQ HELQ ISG20 ISG20 CHD4 CHD4 CHD1L CHD1L DNA2 DNA2 DHX9 DHX9 POLG POLG HELLS HELLS REV3L REV3L
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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C17orf64Chromosome 17 open reading frame 64. (236 aa)
DDX11DEAD/H-box helicase 11. (906 aa)
ENSRBIP00000034301Ribosomal_S3_C domain-containing protein. (253 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
SETXSenataxin. (2655 aa)
RFC1Replication factor C subunit 1. (1114 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (345 aa)
DNMT3BUncharacterized protein. (834 aa)
LOC108523445Uncharacterized protein. (106 aa)
ALKBH4AlkB homolog 4, lysine demethylase. (302 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (959 aa)
LIG4DNA ligase. (901 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (998 aa)
XRCC6X-ray repair cross complementing 6. (568 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa)
HMGA2High mobility group AT-hook 2. (147 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (572 aa)
XRCC2X-ray repair cross complementing 2. (281 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2535 aa)
ARID3AAT-rich interaction domain 3A. (477 aa)
HELBDNA helicase B. (1087 aa)
DNASE2Uncharacterized protein. (119 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1679 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1556 aa)
PRIMPOLPrimase and DNA directed polymerase. (551 aa)
ZGRF1DUF2439 domain-containing protein. (1060 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1343 aa)
MPGN-methylpurine DNA glycosylase. (284 aa)
ENSRBIP00000000510Uncharacterized protein. (105 aa)
NEIL1Nei like DNA glycosylase 1. (390 aa)
MSH3MutS homolog 3. (1195 aa)
TOP1MTDNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (601 aa)
RAD51DRAD51 paralog D. (347 aa)
POLNDNA polymerase nu. (892 aa)
ENSRBIP00000001755Uncharacterized protein. (218 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (991 aa)
FANCMFA complementation group M. (2047 aa)
ENSRBIP00000002430Ribosomal_S3_C domain-containing protein. (168 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
MYO18AMyosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2212 aa)
RBBP8RB binding protein 8, endonuclease. (898 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1053 aa)
DHX36DEAH-box helicase 36. (971 aa)
MGME1Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (342 aa)
CHD1Chromodomain helicase DNA binding protein 1. (1686 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (509 aa)
IGHMBP2Immunoglobulin mu DNA binding protein 2. (985 aa)
EP400E1A binding protein p400. (3059 aa)
ENSRBIP00000041364Ku domain-containing protein. (498 aa)
SELENOVSelenoprotein V. (327 aa)
LIG1DNA ligase. (928 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (376 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2986 aa)
RAD17RAD17 checkpoint clamp loader component. (676 aa)
RAD54LRAD54 like. (747 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (278 aa)
RSF1Remodeling and spacing factor 1. (1441 aa)
MSH4MutS homolog 4. (935 aa)
UPF1UPF1 RNA helicase and ATPase. (1068 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
ENSRBIP00000003378Metallophos domain-containing protein. (233 aa)
HLTFHelicase like transcription factor. (999 aa)
MCM8MCM domain-containing protein; Belongs to the MCM family. (880 aa)
ERCC6L2ERCC excision repair 6 like 2. (691 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1305 aa)
DICER1Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1920 aa)
GTF2F2General transcription factor IIF subunit 2. (232 aa)
NEIL3Nei like DNA glycosylase 3. (594 aa)
POLQDNA polymerase theta. (2717 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1559 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1226 aa)
MGMTMethyltransf_1N domain-containing protein. (122 aa)
DNASE2BDeoxyribonuclease 2 beta. (364 aa)
N6AMT1N-6 adenine-specific DNA methyltransferase 1. (214 aa)
ENDOGEndonuclease. (282 aa)
PLD4Phospholipase D family member 4. (306 aa)
ALKBH1AlkB homolog 1, histone H2A dioxygenase. (389 aa)
OGG18-oxoguanine DNA glycosylase. (391 aa)
SHPRHSNF2 histone linker PHD RING helicase. (1682 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
MLH1MutL homolog 1. (754 aa)
BTAF1B-TFIID TATA-box binding protein associated factor 1. (1857 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (536 aa)
MSH5DNA_MISMATCH_REPAIR_2 domain-containing protein. (778 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (782 aa)
MBD4Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (572 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1140 aa)
PGBD5PiggyBac transposable element derived 5. (508 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1515 aa)
DFFBDNA fragmentation factor subunit beta. (363 aa)
CECR2CECR2 histone acetyl-lysine reader. (1419 aa)
TM4SF19Uncharacterized protein. (295 aa)
POLHDNA polymerase eta. (697 aa)
DKC1Dyskerin pseudouridine synthase 1. (597 aa)
ENSRBIP00000009490Uncharacterized protein. (81 aa)
ENSRBIP00000009858Uncharacterized protein. (392 aa)
ATAD5ATPase family AAA domain containing 5. (1718 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (766 aa)
EXOGExo/endonuclease G. (370 aa)
LIG3DNA ligase. (950 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (346 aa)
DNASE1L3Deoxyribonuclease; Belongs to the DNase I family. (305 aa)
ENSRBIP00000011182Ku domain-containing protein. (328 aa)
ENSRBIP00000011440HELICc2 domain-containing protein. (117 aa)
SMUG1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (270 aa)
BLMBLM RecQ like helicase. (1396 aa)
ENSRBIP00000012004Uncharacterized protein. (450 aa)
HMGA1Uncharacterized protein. (201 aa)
DNASE1L1Deoxyribonuclease 1 like 1. (211 aa)
MEIOBMeiosis specific with OB-fold. (449 aa)
WRNIP1WRN helicase interacting protein 1. (663 aa)
ENSRBIP00000013167AAA_12 domain-containing protein. (221 aa)
ENSRBIP00000013303Uncharacterized protein. (138 aa)
ENSRBIP00000013617Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (245 aa)
EXD2Exonuclease 3'-5' domain containing 2. (621 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
TEP1Telomerase associated protein 1. (2633 aa)
SETMARSET domain and mariner transposase fusion gene. (684 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
TDGThymine DNA glycosylase. (397 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (347 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (907 aa)
MLH3MutL homolog 3. (1449 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (675 aa)
PLD3Phospholipase D family member 3. (490 aa)
SUPV3L1Suv3 like RNA helicase. (544 aa)
DNMT1-2DMAP-interaction domain-containing protein. (89 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (407 aa)
RAD51CRAD51 paralog C. (376 aa)
DNMT3ADNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (912 aa)
ANKLE1Ankyrin repeat and LEM domain containing 1. (669 aa)
WRNWRN RecQ like helicase. (1394 aa)
INO80INO80 complex ATPase subunit. (1555 aa)
TATDN1TatD DNase domain containing 1. (299 aa)
SMC6Structural maintenance of chromosomes 6. (1040 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1978 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1167 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa)
RAD54L2RAD54 like 2. (1467 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (573 aa)
DCLRE1BDNA cross-link repair 1B. (532 aa)
POLD1DNA polymerase. (1124 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
DCLRE1ADNA cross-link repair 1A. (1040 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa)
ENSRBIP00000017801Uncharacterized protein. (86 aa)
XRCC5X-ray repair cross complementing 5. (805 aa)
POLIDNA polymerase iota. (738 aa)
LOC108525261Uncharacterized protein. (75 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
RECQL4RecQ like helicase 4. (1197 aa)
ENSRBIP00000019290KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (242 aa)
CHD3Chromodomain helicase DNA binding protein 3. (2012 aa)
ENSRBIP00000019555Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (743 aa)
HFM1Helicase ATP-binding domain-containing protein. (471 aa)
ENSRBIP00000019958Uncharacterized protein. (231 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1017 aa)
DNASE1Deoxyribonuclease; Belongs to the DNase I family. (285 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (908 aa)
ALKBH3AlkB homolog 3, alpha-ketoglutaratedependent dioxygenase. (286 aa)
ENSRBIP00000020474MTS domain-containing protein. (205 aa)
MCM2DNA helicase; Belongs to the MCM family. (907 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2253 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
NAV2Neuron navigator 2. (2452 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
PMS1PMS1 homolog 1, mismatch repair system component. (933 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1484 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
ENSRBIP00000022922Protein kinase domain-containing protein. (254 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
C11orf80Chromosome 11 open reading frame 80. (511 aa)
CHD9Uncharacterized protein. (2416 aa)
ENSRBIP00000023338Uncharacterized protein. (572 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (404 aa)
APLFAprataxin and PNKP like factor. (511 aa)
SRCAPUncharacterized protein. (3230 aa)
ENSRBIP00000024049EP400_N domain-containing protein. (391 aa)
RAD51BRAD51 paralog B. (426 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (752 aa)
RAD1Uncharacterized protein. (280 aa)
POLG2DNA polymerase gamma 2, accessory subunit. (485 aa)
MCM3DNA helicase; Belongs to the MCM family. (828 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (518 aa)
POLD4Uncharacterized protein. (107 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (117 aa)
ERCC6LERCC excision repair 6 like, spindle assembly checkpoint helicase. (1200 aa)
EXO1Exonuclease 1. (827 aa)
CHD2Uncharacterized protein. (1799 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (492 aa)
METTL4Methyltransferase like 4; Belongs to the MT-A70-like family. (410 aa)
TDP2Tyrosyl-DNA phosphodiesterase 2. (358 aa)
HAUS3HAUS augmin like complex subunit 3. (603 aa)
POLKDNA polymerase kappa. (866 aa)
CHD6BRK domain-containing protein. (1359 aa)
ENSRBIP00000027300FTO_CTD domain-containing protein. (127 aa)
ENSRBIP00000027339Nucleoside diphosphate kinase. (176 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
REXO2RNA exonuclease 2. (237 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1482 aa)
FBH1F-box DNA helicase 1. (1079 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (322 aa)
LOC108520834Helicase ATP-binding domain-containing protein. (705 aa)
ENSRBIP00000029216FTO_NTD domain-containing protein. (461 aa)
MCM6DNA helicase; Belongs to the MCM family. (821 aa)
MPHOSPH9M-phase phosphoprotein 9. (1132 aa)
RFC3Replication factor C subunit 3. (356 aa)
APTXAprataxin. (368 aa)
TENT4BTerminal nucleotidyltransferase 4B. (673 aa)
TWNKTwinkle mtDNA helicase. (684 aa)
NEIL2Nei like DNA glycosylase 2. (332 aa)
CEP41Centrosomal protein 41. (373 aa)
CHRAC1Chromatin accessibility complex subunit 1. (82 aa)
TTF2Transcription termination factor 2. (1170 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (312 aa)
ENDOVEndonuclease V. (281 aa)
ASCC3Helicase C-terminal domain-containing protein. (665 aa)
ALKBH2AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase. (261 aa)
G3BP1G3BP stress granule assembly factor 1. (466 aa)
ENSRBIP00000037360KH type-2 domain-containing protein. (143 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa)
ENSRBIP00000037149MTS domain-containing protein. (205 aa)
DDX1DEAD-box helicase 1. (734 aa)
ENSRBIP00000036862Ku domain-containing protein. (567 aa)
SMARCAD1Uncharacterized protein. (1026 aa)
DQX1DEAQ-box RNA dependent ATPase 1. (717 aa)
HELQHelicase, POLQ like. (1101 aa)
ISG20Interferon stimulated exonuclease gene 20. (181 aa)
CHD4Uncharacterized protein. (1906 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (899 aa)
DNA2DNA replication helicase/nuclease 2. (1047 aa)
DHX9DExH-box helicase 9. (1275 aa)
POLGDNA polymerase gamma, catalytic subunit. (1234 aa)
HELLSHelicase, lymphoid specific. (877 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3106 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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