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DRD2 DRD2 RHBDF2 RHBDF2 ABCC8 ABCC8 RAB11FIP3 RAB11FIP3 ANXA1 ANXA1 CBARP CBARP INHBB INHBB GHSR GHSR BCR BCR ENSRBIP00000009767 ENSRBIP00000009767 SIRT4 SIRT4 FMR1 FMR1 ATP9A ATP9A ADRA2B ADRA2B CARTPT CARTPT RAB33B RAB33B ENSRBIP00000002079 ENSRBIP00000002079 PPP3CA PPP3CA LIF LIF ENSRBIP00000001234 ENSRBIP00000001234 RAB11FIP5 RAB11FIP5 CRH CRH NR1H3 NR1H3 HADH HADH SREBF1 SREBF1 CEACAM1 CEACAM1 ENSRBIP00000011319 ENSRBIP00000011319 SYT4 SYT4 STXBP6 STXBP6 ASIC1 ASIC1 ADIPOQ ADIPOQ MIDN MIDN SERGEF SERGEF IRS1 IRS1 REST REST HTR1B HTR1B SMCR8 SMCR8 PNKD PNKD ADTRP ADTRP SFRP1 SFRP1 ENSRBIP00000016878 ENSRBIP00000016878 NCKAP1L NCKAP1L VAMP8 VAMP8 NPVF NPVF STXBP3 STXBP3 CCN3 CCN3 CHGA CHGA INHBA INHBA TRH TRH ERP29 ERP29 CRY1 CRY1 APOE APOE RHBDF1 RHBDF1 OSM OSM BRAF BRAF RAB7A RAB7A NOTCH1 NOTCH1 HLA-F HLA-F KCNB1 KCNB1 FFAR4 FFAR4 INHA INHA CRY2 CRY2 LOC108517114 LOC108517114 PPP3CA-2 PPP3CA-2 RAP1A RAP1A KCNJ11 KCNJ11 DRD3 DRD3 LOC108543093 LOC108543093 PFKL PFKL P2RY1 P2RY1 ENSRBIP00000006344 ENSRBIP00000006344 FOXO1 FOXO1 KALRN KALRN TSPO TSPO TACR2 TACR2 NF1 NF1 C9orf72 C9orf72 ENSRBIP00000042593 ENSRBIP00000042593 FOXF1 FOXF1 SRCIN1 SRCIN1 ENSRBIP00000041657 ENSRBIP00000041657 LEP LEP ENSRBIP00000039905 ENSRBIP00000039905 VSNL1 VSNL1 TNFRSF1A TNFRSF1A IL1RAPL1 IL1RAPL1 TNFRSF1B TNFRSF1B HRH3 HRH3 NMB NMB F2R F2R RABGEF1 RABGEF1 ABAT ABAT CD84 CD84 ADRA2A ADRA2A MTNR1B MTNR1B IL13RA2 IL13RA2 NDUFAF2 NDUFAF2 ACVR1C ACVR1C STXBP5L STXBP5L PSMD9 PSMD9 SYT11 SYT11 KLF7 KLF7 WDR41 WDR41 FKBP1B FKBP1B ENSRBIP00000032719 ENSRBIP00000032719 IL12A IL12A GABBR1 GABBR1 OPRM1 OPRM1 CRHBP CRHBP FRMD4A FRMD4A DPH3 DPH3 ENSRBIP00000029930 ENSRBIP00000029930 GHRL GHRL FAM3D FAM3D SYTL4 SYTL4 RSAD2 RSAD2 FGF23 FGF23 RAB11FIP1 RAB11FIP1 PTPN11 PTPN11 ENSRBIP00000026419 ENSRBIP00000026419 ENSRBIP00000007185 ENSRBIP00000007185 ENSRBIP00000007353 ENSRBIP00000007353 PRKN PRKN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
RHBDF2Rhomboid 5 homolog 2. (891 aa)
ABCC8ATP binding cassette subfamily C member 8. (1585 aa)
RAB11FIP3RAB11 family interacting protein 3. (739 aa)
ANXA1Annexin. (346 aa)
CBARPCACN subunit beta associated regulatory protein. (416 aa)
INHBBInhibin subunit beta B. (407 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
BCRBCR activator of RhoGEF and GTPase. (1089 aa)
ENSRBIP00000009767Uncharacterized protein. (546 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
FMR1Fragile X mental retardation 1. (595 aa)
ATP9APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1081 aa)
ADRA2BAdrenoceptor alpha 2B. (451 aa)
CARTPTCART prepropeptide. (116 aa)
RAB33BRAB33B, member RAS oncogene family. (229 aa)
ENSRBIP00000002079Uncharacterized protein. (202 aa)
PPP3CASerine/threonine-protein phosphatase. (310 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
ENSRBIP00000001234Uncharacterized protein. (93 aa)
RAB11FIP5Uncharacterized protein. (1319 aa)
CRHCorticotropin releasing hormone. (196 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (441 aa)
HADHHydroxyacyl-CoA dehydrogenase. (341 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1047 aa)
CEACAM1Uncharacterized protein. (525 aa)
ENSRBIP00000011319Protein kinase domain-containing protein. (265 aa)
SYT4Synaptotagmin 4. (424 aa)
STXBP6Syntaxin binding protein 6. (210 aa)
ASIC1Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (574 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (275 aa)
MIDNMidnolin. (385 aa)
SERGEFSecretion regulating guanine nucleotide exchange factor. (448 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
RESTRE1 silencing transcription factor. (1080 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
SMCR8SMCR8-C9orf72 complex subunit. (936 aa)
PNKDPNKD metallo-beta-lactamase domain containing. (385 aa)
ADTRPAndrogen dependent TFPI regulating protein. (248 aa)
SFRP1Secreted frizzled related protein 1. (313 aa)
ENSRBIP00000016878Uncharacterized protein. (251 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
VAMP8Vesicle associated membrane protein 8. (100 aa)
NPVFNeuropeptide VF precursor. (166 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (548 aa)
CCN3Cellular communication network factor 3. (357 aa)
CHGAChromogranin A. (510 aa)
INHBAInhibin subunit beta A. (426 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (242 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
CRY1Cryptochrome circadian regulator 1. (586 aa)
APOEApolipoprotein E. (317 aa)
RHBDF1Rhomboid 5 homolog 1. (890 aa)
OSMOncostatin M. (231 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (753 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
NOTCH1Notch receptor 1. (2438 aa)
HLA-FMajor histocompatibility complex, class I, F; Belongs to the MHC class I family. (369 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
FFAR4Free fatty acid receptor 4. (377 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (367 aa)
CRY2Cryptochrome circadian regulator 2. (613 aa)
LOC108517114Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
PPP3CA-2Uncharacterized protein. (70 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
KCNJ11Potassium voltage-gated channel subfamily J member 11. (390 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (400 aa)
LOC108543093Ig-like domain-containing protein; Belongs to the MHC class I family. (378 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (774 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
ENSRBIP00000006344C2H2-type domain-containing protein. (250 aa)
FOXO1Forkhead box O1. (539 aa)
KALRNKalirin RhoGEF kinase. (2940 aa)
TSPOTranslocator protein. (169 aa)
TACR2Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (398 aa)
NF1Neurofibromin 1. (2822 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
ENSRBIP00000042593Uncharacterized protein. (229 aa)
FOXF1Forkhead box F1. (380 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1395 aa)
ENSRBIP00000041657V-SNARE coiled-coil homology domain-containing protein. (98 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ENSRBIP00000039905VPS9 domain-containing protein. (259 aa)
VSNL1Visinin like 1. (191 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
IL1RAPL1TIR domain-containing protein. (295 aa)
TNFRSF1BTNF receptor superfamily member 1B. (462 aa)
HRH3Histamine receptor H3; Belongs to the G-protein coupled receptor 1 family. (405 aa)
NMBUncharacterized protein. (203 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (425 aa)
RABGEF1Uncharacterized protein. (430 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (506 aa)
CD84CD84 molecule. (328 aa)
ADRA2AAdrenoceptor alpha 2A. (400 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (362 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (348 aa)
NDUFAF2NADH:ubiquinone oxidoreductase complex assembly factor 2. (111 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (413 aa)
STXBP5LSyntaxin binding protein 5 like. (1180 aa)
PSMD9PDZ domain-containing protein. (223 aa)
SYT11Synaptotagmin 11. (431 aa)
KLF7Kruppel like factor 7. (302 aa)
WDR41WD repeat domain 41. (459 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
ENSRBIP00000032719SH2 domain-containing protein. (203 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1. (1046 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (446 aa)
CRHBPCorticotropin releasing hormone binding protein. (275 aa)
FRMD4AFERM domain containing 4A. (1083 aa)
DPH3Diphthamide biosynthesis 3. (82 aa)
ENSRBIP00000029930Amino_oxidase domain-containing protein. (205 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
FAM3DFamily with sequence similarity 3 member D. (224 aa)
SYTL4Synaptotagmin like 4. (672 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (360 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
RAB11FIP1RAB11 family interacting protein 1. (1283 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
ENSRBIP00000026419Uncharacterized protein. (249 aa)
ENSRBIP00000007185Ig-like domain-containing protein; Belongs to the MHC class I family. (392 aa)
ENSRBIP00000007353A20-type domain-containing protein. (128 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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