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MLH3 | MutL homolog 3. (1449 aa) | ||||
PMS1 | PMS1 homolog 1, mismatch repair system component. (933 aa) | ||||
TP53BP1 | Tumor protein p53 binding protein 1. (1943 aa) | ||||
POLD1 | DNA polymerase. (1124 aa) | ||||
ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa) | ||||
XRCC5 | X-ray repair cross complementing 5. (805 aa) | ||||
PHF21A | PHD finger protein 21A. (680 aa) | ||||
RAD23B | RAD23 homolog B, nucleotide excision repair protein. (375 aa) | ||||
ENSRBIP00000041364 | Ku domain-containing protein. (498 aa) | ||||
NHEJ1 | Non-homologous end joining factor 1. (299 aa) | ||||
BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1818 aa) | ||||
ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (289 aa) | ||||
ASCC3 | Helicase C-terminal domain-containing protein. (665 aa) | ||||
ENSRBIP00000036862 | Ku domain-containing protein. (567 aa) | ||||
PAXX | PAXX non-homologous end joining factor. (204 aa) | ||||
ZSWIM7 | Zinc finger SWIM-type containing 7. (132 aa) | ||||
LIG4 | DNA ligase. (901 aa) | ||||
KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (883 aa) | ||||
XRCC6 | X-ray repair cross complementing 6. (568 aa) | ||||
PMS2 | PMS1 homolog 2, mismatch repair system component. (572 aa) | ||||
SWSAP1 | SWIM-type zinc finger 7 associated protein 1. (250 aa) | ||||
LOC108520834 | Helicase ATP-binding domain-containing protein. (705 aa) | ||||
RCOR1 | REST corepressor 1. (397 aa) | ||||
BRCA2 | Uncharacterized protein. (386 aa) | ||||
ENSRBIP00000000510 | Uncharacterized protein. (105 aa) | ||||
FANCI | FA complementation group I. (1288 aa) | ||||
MSH3 | MutS homolog 3. (1195 aa) | ||||
DCLRE1C | DNA cross-link repair 1C. (689 aa) | ||||
CETN2 | Centrin 2. (172 aa) | ||||
ENSRBIP00000001755 | Uncharacterized protein. (218 aa) | ||||
MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1305 aa) | ||||
FANCD2 | Uncharacterized protein. (1422 aa) | ||||
UPK3B | Uncharacterized protein. (378 aa) | ||||
MLH1 | MutL homolog 1. (754 aa) | ||||
ASCC1 | Activating signal cointegrator 1 complex subunit 1. (400 aa) | ||||
XPA | XPA, DNA damage recognition and repair factor. (303 aa) | ||||
ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (370 aa) | ||||
XRCC4 | X-ray repair cross complementing 4. (231 aa) | ||||
XPC | XPC complex subunit, DNA damage recognition and repair factor. (939 aa) | ||||
PALB2 | Partner and localizer of BRCA2. (1149 aa) | ||||
ENSRBIP00000011182 | Ku domain-containing protein. (328 aa) | ||||
PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa) | ||||
ATP23 | Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (246 aa) | ||||
ASCC2 | Activating signal cointegrator 1 complex subunit 2. (753 aa) | ||||
MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa) | ||||
ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (907 aa) |