46 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MLH3	MutL homolog 3. (1449 aa)
	PMS1	PMS1 homolog 1, mismatch repair system component. (933 aa)
	TP53BP1	Tumor protein p53 binding protein 1. (1943 aa)
	POLD1	DNA polymerase. (1124 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa)
	XRCC5	X-ray repair cross complementing 5. (805 aa)
	PHF21A	PHD finger protein 21A. (680 aa)
	RAD23B	RAD23 homolog B, nucleotide excision repair protein. (375 aa)
	ENSRBIP00000041364	Ku domain-containing protein. (498 aa)
	NHEJ1	Non-homologous end joining factor 1. (299 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1818 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (289 aa)
	ASCC3	Helicase C-terminal domain-containing protein. (665 aa)
	ENSRBIP00000036862	Ku domain-containing protein. (567 aa)
	PAXX	PAXX non-homologous end joining factor. (204 aa)
	ZSWIM7	Zinc finger SWIM-type containing 7. (132 aa)
	LIG4	DNA ligase. (901 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (883 aa)
	XRCC6	X-ray repair cross complementing 6. (568 aa)
	PMS2	PMS1 homolog 2, mismatch repair system component. (572 aa)
	SWSAP1	SWIM-type zinc finger 7 associated protein 1. (250 aa)
	LOC108520834	Helicase ATP-binding domain-containing protein. (705 aa)
	RCOR1	REST corepressor 1. (397 aa)
	BRCA2	Uncharacterized protein. (386 aa)
	ENSRBIP00000000510	Uncharacterized protein. (105 aa)
	FANCI	FA complementation group I. (1288 aa)
	MSH3	MutS homolog 3. (1195 aa)
	DCLRE1C	DNA cross-link repair 1C. (689 aa)
	CETN2	Centrin 2. (172 aa)
	ENSRBIP00000001755	Uncharacterized protein. (218 aa)
	MSH6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1305 aa)
	FANCD2	Uncharacterized protein. (1422 aa)
	UPK3B	Uncharacterized protein. (378 aa)
	MLH1	MutL homolog 1. (754 aa)
	ASCC1	Activating signal cointegrator 1 complex subunit 1. (400 aa)
	XPA	XPA, DNA damage recognition and repair factor. (303 aa)
	ERCC8	ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (370 aa)
	XRCC4	X-ray repair cross complementing 4. (231 aa)
	XPC	XPC complex subunit, DNA damage recognition and repair factor. (939 aa)
	PALB2	Partner and localizer of BRCA2. (1149 aa)
	ENSRBIP00000011182	Ku domain-containing protein. (328 aa)
	PRKDC	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
	ATP23	Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (246 aa)
	ASCC2	Activating signal cointegrator 1 complex subunit 2. (753 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (907 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCC1	ASCC2	ENSRBIP00000019045	ENSRBIP00000014457	Activating signal cointegrator 1 complex subunit 1.	Activating signal cointegrator 1 complex subunit 2.	0.956
ASCC1	ASCC3	ENSRBIP00000019045	ENSRBIP00000037662	Activating signal cointegrator 1 complex subunit 1.	Helicase C-terminal domain-containing protein.	0.820
ASCC1	DCLRE1C	ENSRBIP00000019045	ENSRBIP00000001132	Activating signal cointegrator 1 complex subunit 1.	DNA cross-link repair 1C.	0.411
ASCC1	ERCC8	ENSRBIP00000019045	ENSRBIP00000025822	Activating signal cointegrator 1 complex subunit 1.	ERCC excision repair 8, CSA ubiquitin ligase complex subunit.	0.418
ASCC1	LOC108520834	ENSRBIP00000019045	ENSRBIP00000029047	Activating signal cointegrator 1 complex subunit 1.	Helicase ATP-binding domain-containing protein.	0.820
ASCC1	PMS2	ENSRBIP00000019045	ENSRBIP00000031396	Activating signal cointegrator 1 complex subunit 1.	PMS1 homolog 2, mismatch repair system component.	0.425
ASCC2	ASCC1	ENSRBIP00000014457	ENSRBIP00000019045	Activating signal cointegrator 1 complex subunit 2.	Activating signal cointegrator 1 complex subunit 1.	0.956
ASCC2	ASCC3	ENSRBIP00000014457	ENSRBIP00000037662	Activating signal cointegrator 1 complex subunit 2.	Helicase C-terminal domain-containing protein.	0.944
ASCC2	LOC108520834	ENSRBIP00000014457	ENSRBIP00000029047	Activating signal cointegrator 1 complex subunit 2.	Helicase ATP-binding domain-containing protein.	0.944
ASCC2	RAD23B	ENSRBIP00000014457	ENSRBIP00000042869	Activating signal cointegrator 1 complex subunit 2.	RAD23 homolog B, nucleotide excision repair protein.	0.428
ASCC3	ASCC1	ENSRBIP00000037662	ENSRBIP00000019045	Helicase C-terminal domain-containing protein.	Activating signal cointegrator 1 complex subunit 1.	0.820
ASCC3	ASCC2	ENSRBIP00000037662	ENSRBIP00000014457	Helicase C-terminal domain-containing protein.	Activating signal cointegrator 1 complex subunit 2.	0.944
ASCC3	LOC108520834	ENSRBIP00000037662	ENSRBIP00000029047	Helicase C-terminal domain-containing protein.	Helicase ATP-binding domain-containing protein.	0.928
ASCC3	MLH1	ENSRBIP00000037662	ENSRBIP00000007384	Helicase C-terminal domain-containing protein.	MutL homolog 1.	0.489
ASCC3	MLH3	ENSRBIP00000037662	ENSRBIP00000014905	Helicase C-terminal domain-containing protein.	MutL homolog 3.	0.443
ASCC3	MSH2	ENSRBIP00000037662	ENSRBIP00000014641	Helicase C-terminal domain-containing protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.403
ATM	BRCA1	ENSRBIP00000020338	ENSRBIP00000041182	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.996
ATM	BRCA2	ENSRBIP00000020338	ENSRBIP00000000297	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.903
ATM	DCLRE1C	ENSRBIP00000020338	ENSRBIP00000001132	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA cross-link repair 1C.	0.768
ATM	ENSRBIP00000000510	ENSRBIP00000020338	ENSRBIP00000000510	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.662