STRINGSTRING
MLH3 MLH3 PMS1 PMS1 TP53BP1 TP53BP1 POLD1 POLD1 ATM ATM XRCC5 XRCC5 PHF21A PHF21A RAD23B RAD23B ENSRBIP00000041364 ENSRBIP00000041364 NHEJ1 NHEJ1 BRCA1 BRCA1 ERCC1 ERCC1 ASCC3 ASCC3 ENSRBIP00000036862 ENSRBIP00000036862 PAXX PAXX ZSWIM7 ZSWIM7 LIG4 LIG4 KDM1A KDM1A XRCC6 XRCC6 PMS2 PMS2 SWSAP1 SWSAP1 LOC108520834 LOC108520834 RCOR1 RCOR1 BRCA2 BRCA2 ENSRBIP00000000510 ENSRBIP00000000510 FANCI FANCI MSH3 MSH3 DCLRE1C DCLRE1C CETN2 CETN2 ENSRBIP00000001755 ENSRBIP00000001755 MSH6 MSH6 FANCD2 FANCD2 UPK3B UPK3B MLH1 MLH1 ASCC1 ASCC1 XPA XPA ERCC8 ERCC8 XRCC4 XRCC4 XPC XPC PALB2 PALB2 ENSRBIP00000011182 ENSRBIP00000011182 PRKDC PRKDC ATP23 ATP23 ASCC2 ASCC2 MSH2 MSH2 ERCC4 ERCC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MLH3MutL homolog 3. (1449 aa)
PMS1PMS1 homolog 1, mismatch repair system component. (933 aa)
TP53BP1Tumor protein p53 binding protein 1. (1943 aa)
POLD1DNA polymerase. (1124 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa)
XRCC5X-ray repair cross complementing 5. (805 aa)
PHF21APHD finger protein 21A. (680 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (375 aa)
ENSRBIP00000041364Ku domain-containing protein. (498 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1818 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (289 aa)
ASCC3Helicase C-terminal domain-containing protein. (665 aa)
ENSRBIP00000036862Ku domain-containing protein. (567 aa)
PAXXPAXX non-homologous end joining factor. (204 aa)
ZSWIM7Zinc finger SWIM-type containing 7. (132 aa)
LIG4DNA ligase. (901 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (883 aa)
XRCC6X-ray repair cross complementing 6. (568 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (572 aa)
SWSAP1SWIM-type zinc finger 7 associated protein 1. (250 aa)
LOC108520834Helicase ATP-binding domain-containing protein. (705 aa)
RCOR1REST corepressor 1. (397 aa)
BRCA2Uncharacterized protein. (386 aa)
ENSRBIP00000000510Uncharacterized protein. (105 aa)
FANCIFA complementation group I. (1288 aa)
MSH3MutS homolog 3. (1195 aa)
DCLRE1CDNA cross-link repair 1C. (689 aa)
CETN2Centrin 2. (172 aa)
ENSRBIP00000001755Uncharacterized protein. (218 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1305 aa)
FANCD2Uncharacterized protein. (1422 aa)
UPK3BUncharacterized protein. (378 aa)
MLH1MutL homolog 1. (754 aa)
ASCC1Activating signal cointegrator 1 complex subunit 1. (400 aa)
XPAXPA, DNA damage recognition and repair factor. (303 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (370 aa)
XRCC4X-ray repair cross complementing 4. (231 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (939 aa)
PALB2Partner and localizer of BRCA2. (1149 aa)
ENSRBIP00000011182Ku domain-containing protein. (328 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
ATP23Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (246 aa)
ASCC2Activating signal cointegrator 1 complex subunit 2. (753 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (907 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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