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H2BC21 H2BC21 LOC108516755 LOC108516755 LOC108543823 LOC108543823 LOC108533652 LOC108533652 LOC108513410 LOC108513410 POLR2A POLR2A LOC108512615 LOC108512615 LOC108536802 LOC108536802 LOC108513418 LOC108513418 H3-4 H3-4 H2BC5 H2BC5 LOC108513411-3 LOC108513411-3 BLM BLM LOC108513409 LOC108513409 PPP6R2 PPP6R2 MEIOB MEIOB H2BC3 H2BC3 ENSRBIP00000012852 ENSRBIP00000012852 H2BC11 H2BC11 DAXX DAXX ENSRBIP00000013617 ENSRBIP00000013617 EXD2 EXD2 WRN WRN POLR2H POLR2H TERT TERT ENSRBIP00000017217 ENSRBIP00000017217 POLD1 POLD1 H2AZ2 H2AZ2 POLR2E POLR2E LOC108544889 LOC108544889 DKC1 DKC1 RBPMS2 RBPMS2 RCBTB2 RCBTB2 ENSRBIP00000008656 ENSRBIP00000008656 PCNA PCNA LOC108513393 LOC108513393 ENSRBIP00000006972 ENSRBIP00000006972 LOC108525434 LOC108525434 LOC108515442 LOC108515442 POLR2C POLR2C SHQ1 SHQ1 ENSRBIP00000005985 ENSRBIP00000005985 H2AC20 H2AC20 LOC108513411-2 LOC108513411-2 CHTF8 CHTF8 LOC108530030 LOC108530030 H2BC1 H2BC1 LOC108513437 LOC108513437 LOC108517067 LOC108517067 H2BC13 H2BC13 LOC108540122 LOC108540122 LOC108513411 LOC108513411 LOC108513408 LOC108513408 GAR1 GAR1 LOC108513419 LOC108513419 H2AX H2AX LOC108520555 LOC108520555 NHP2 NHP2 CHTF18 CHTF18 LOC108525496 LOC108525496 LOC108540645 LOC108540645 FEN1 FEN1 LOC108530500-3 LOC108530500-3 H2BU1 H2BU1 LOC108538754 LOC108538754 LOC108530500-2 LOC108530500-2 LOC108530500 LOC108530500 TEN1 TEN1 POLR2G POLR2G POLR2F POLR2F ANKRD66 ANKRD66 PPP6R3 PPP6R3 POLD3 POLD3 PPP6C PPP6C ANKRD44 ANKRD44 PIF1 PIF1 TERF2IP TERF2IP ENSRBIP00000018131 ENSRBIP00000018131 RUVBL1 RUVBL1 TRUB1 TRUB1 RECQL4 RECQL4 POLR2L POLR2L RCBTB1 RCBTB1 RFC2 RFC2 DSCC1 DSCC1 RUVBL2 RUVBL2 POLR2K POLR2K WRAP53 WRAP53 CCNA1 CCNA1 POLD4 POLD4 RPA1 RPA1 ANKRD28 ANKRD28 ENSRBIP00000025761 ENSRBIP00000025761 POLD2 POLD2 POLR2I POLR2I RFC4 RFC4 LOC108537360 LOC108537360 RFC5 RFC5 ENSRBIP00000029015 ENSRBIP00000029015 RTEL1 RTEL1 TERF2 TERF2 ENSRBIP00000030766 ENSRBIP00000030766 POLR2D POLR2D PRIM1 PRIM1 STN1 STN1 CDK3 CDK3 PRIM2 PRIM2 POT1 POT1 RPA3 RPA3 RFC1 RFC1 ENSRBIP00000033764 ENSRBIP00000033764 H2AJ H2AJ ENSRBIP00000034985 ENSRBIP00000034985 DNA2 DNA2 CCNA2 CCNA2 CDK2 CDK2 TINF2 TINF2 ENSRBIP00000037689 ENSRBIP00000037689 POLR2J POLR2J CTC1 CTC1 ACD ACD ENSRBIP00000038474 ENSRBIP00000038474 TERF1 TERF1 ENSRBIP00000038793 ENSRBIP00000038793 POLR2B POLR2B RFC3 RFC3 H2BC15 H2BC15 LIG1 LIG1 POLA2 POLA2 H2AC6 H2AC6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108516755Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108543823Histone H3; Belongs to the histone H3 family. (136 aa)
LOC108533652Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC108513410Histone H2A; Belongs to the histone H2A family. (130 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1941 aa)
LOC108512615Histone domain-containing protein; Belongs to the histone H2B family. (168 aa)
LOC108536802Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108513418Histone H4. (103 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108513411-3Histone H2B type 1. (126 aa)
BLMBLM RecQ like helicase. (1396 aa)
LOC108513409Histone H2A; Belongs to the histone H2A family. (131 aa)
PPP6R2Protein phosphatase 6 regulatory subunit 2. (922 aa)
MEIOBMeiosis specific with OB-fold. (449 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSRBIP00000012852Uncharacterized protein. (77 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
DAXXDeath domain associated protein. (740 aa)
ENSRBIP00000013617Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (245 aa)
EXD2Exonuclease 3'-5' domain containing 2. (621 aa)
WRNWRN RecQ like helicase. (1394 aa)
POLR2HRNA polymerase II subunit H. (174 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1167 aa)
ENSRBIP00000017217Uncharacterized protein. (71 aa)
POLD1DNA polymerase. (1124 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (128 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
LOC108544889Histone domain-containing protein; Belongs to the histone H2B family. (168 aa)
DKC1Dyskerin pseudouridine synthase 1. (597 aa)
RBPMS2Uncharacterized protein. (98 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
ENSRBIP00000008656Histone H2A; Belongs to the histone H2A family. (139 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
LOC108513393Histone H2B type 1. (126 aa)
ENSRBIP00000006972Uncharacterized protein. (194 aa)
LOC108525434Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108515442Histone H2A; Belongs to the histone H2A family. (146 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
SHQ1SHQ1, H/ACA ribonucleoprotein assembly factor. (554 aa)
ENSRBIP00000005985Uncharacterized protein. (64 aa)
H2AC20Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC108513411-2Histone H2B type 1. (126 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
LOC108530030Histone domain-containing protein. (136 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC108513437Histone H4. (103 aa)
LOC108517067Uncharacterized protein. (64 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108540122Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108513411Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108513408Histone H2A type 1. (130 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (217 aa)
LOC108513419Histone H4. (103 aa)
H2AXHistone H2A; Belongs to the histone H2A family. (143 aa)
LOC108520555Histone H4. (103 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
CHTF18Chromosome transmission fidelity factor 18. (999 aa)
LOC108525496Histone H4-like. (101 aa)
LOC108540645Histone domain-containing protein. (136 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
LOC108530500-3Histone H4. (103 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108538754Histone H3; Belongs to the histone H3 family. (124 aa)
LOC108530500-2Histone H4. (103 aa)
LOC108530500Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
TEN1Uncharacterized protein. (123 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
POLR2FRNA polymerase II subunit F. (150 aa)
ANKRD66Ankyrin repeat domain 66. (250 aa)
PPP6R3Protein phosphatase 6 regulatory subunit 3. (879 aa)
POLD3Uncharacterized protein. (454 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
ANKRD44Ankyrin repeat domain 44. (969 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa)
TERF2IPTERF2 interacting protein. (400 aa)
ENSRBIP00000018131Histone H2B; Belongs to the histone H2B family. (129 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
TRUB1TruB pseudouridine synthase family member 1. (324 aa)
RECQL4RecQ like helicase 4. (1197 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
RFC2Replication factor C subunit 2. (352 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (416 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
POLR2KRNA polymerase II subunit K. (58 aa)
WRAP53WD repeat containing antisense to TP53. (549 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
POLD4Uncharacterized protein. (107 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
ANKRD28Ankyrin repeat domain 28. (1083 aa)
ENSRBIP00000025761TINF2_N domain-containing protein. (517 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
RFC4Replication factor C subunit 4. (362 aa)
LOC108537360Histone H3.3. (136 aa)
RFC5Replication factor C subunit 5. (309 aa)
ENSRBIP00000029015Histone H2A; Belongs to the histone H2A family. (127 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1343 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (421 aa)
ENSRBIP00000030766Histone H2A; Belongs to the histone H2A family. (89 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (486 aa)
POT1Protection of telomeres 1. (633 aa)
RPA3Replication protein A3. (121 aa)
RFC1Replication factor C subunit 1. (1114 aa)
ENSRBIP00000033764Histone H2B; Belongs to the histone H2B family. (134 aa)
H2AJHistone H2A; Belongs to the histone H2A family. (158 aa)
ENSRBIP00000034985TINF2_N domain-containing protein. (339 aa)
DNA2DNA replication helicase/nuclease 2. (1047 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa)
TINF2TINF2_N domain-containing protein. (451 aa)
ENSRBIP00000037689H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (191 aa)
POLR2JRNA_pol_L_2 domain-containing protein. (159 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (528 aa)
ENSRBIP00000038474Histone H2A; Belongs to the histone H2A family. (131 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (406 aa)
ENSRBIP00000038793Histone H2A; Belongs to the histone H2A family. (87 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1156 aa)
RFC3Replication factor C subunit 3. (356 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (166 aa)
LIG1DNA ligase. (928 aa)
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
H2AC6Histone H2A; Belongs to the histone H2A family. (130 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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