67 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	RXRA	Retinoid X receptor alpha. (492 aa)
	MBTPS2	Membrane bound transcription factor peptidase, site 2. (442 aa)
	TGS1	Trimethylguanosine synthase 1. (843 aa)
	MVK	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
	ACACB	Acetyl-CoA carboxylase beta. (2458 aa)
	SP1	Sp1 transcription factor. (769 aa)
	IDI1	Isopentenyl-diphosphate delta isomerase 1. (280 aa)
	SQLE	Squalene epoxidase. (574 aa)
	NFYB	CBFD_NFYB_HMF domain-containing protein. (208 aa)
	GGPS1	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (300 aa)
	SC5D	Sterol-C5-desaturase; Belongs to the sterol desaturase family. (299 aa)
	SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (501 aa)
	CREBBP	CREB binding protein. (2422 aa)
	ENSRBIP00000029827	Uncharacterized protein. (106 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1252 aa)
	ADGRD1	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family. (770 aa)
	NCOA6	Nuclear receptor coactivator 6. (2068 aa)
	FDPS	Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (419 aa)
	ENSRBIP00000027071	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (200 aa)
	ENSRBIP00000026970	Nudix hydrolase domain-containing protein. (159 aa)
	ENSRBIP00000026924	CBFD_NFYB_HMF domain-containing protein. (184 aa)
	SREBF2	Sterol regulatory element binding transcription factor 2. (1138 aa)
	KPNB1	Karyopherin subunit beta 1. (877 aa)
	SEC23B	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (767 aa)
	LSS	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (706 aa)
	SCAP	SREBF chaperone. (1469 aa)
	SAR1A	Uncharacterized protein; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1547 aa)
	NFYA	Nuclear transcription factor Y subunit alpha. (347 aa)
	CYP51A1	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
	ENSRBIP00000012004	Uncharacterized protein. (450 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
	ELOVL6	Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
	SAR1B	Secretion associated Ras related GTPase 1B; Belongs to the small GTPase superfamily. SAR1 family. (198 aa)
	SCD	Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family. (359 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (283 aa)
	FASN	Fatty acid synthase. (2477 aa)
	ENSRBIP00000023977	Uncharacterized protein. (166 aa)
	CHD9	Uncharacterized protein. (2416 aa)
	NCOA1	Nuclear receptor coactivator. (1433 aa)
	MVD	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (401 aa)
	IDI2	Isopentenyl-diphosphate delta isomerase 2. (154 aa)
	SEC24C	Uncharacterized protein. (1077 aa)
	MTF1	Metal regulatory transcription factor 1. (753 aa)
	ENSRBIP00000018460	Uncharacterized protein. (176 aa)
	SEC24D	SEC24 homolog D, COPII coat complex component. (1032 aa)
	PMVK	Phosphomevalonate kinase. (192 aa)
	SEC23A	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
	SREBF1	Sterol regulatory element binding transcription factor 1. (1047 aa)
	FDFT1	Farnesyl-diphosphate farnesyltransferase 1. (468 aa)
	CARM1	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (582 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
	TBL1X	Transducin beta like 1 X-linked. (586 aa)
	HELZ2	Helicase with zinc finger 2. (2649 aa)
	ENSRBIP00000042758	Uncharacterized protein. (1677 aa)
	RAN	GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (233 aa)
	SEC24A	SEC24 homolog A, COPII coat complex component. (986 aa)
	NCOA2	Nuclear receptor coactivator. (1475 aa)
	GPAM	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
	DHCR7	7-dehydrocholesterol reductase. (475 aa)
	MBTPS1	Membrane bound transcription factor peptidase, site 1. (1052 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (514 aa)
	TM7SF2	Transmembrane 7 superfamily member 2. (418 aa)
	ENSRBIP00000007485	Biotin carboxylation domain-containing protein. (156 aa)
	PPARA	Peroxisome proliferator activated receptor alpha. (468 aa)
	NFYC	Nuclear transcription factor Y subunit gamma. (439 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACB	ELOVL6	ENSRBIP00000035944	ENSRBIP00000026190	Acetyl-CoA carboxylase beta.	Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...]	0.419
ACACB	FASN	ENSRBIP00000035944	ENSRBIP00000023412	Acetyl-CoA carboxylase beta.	Fatty acid synthase.	0.969
ACACB	SCD	ENSRBIP00000035944	ENSRBIP00000025633	Acetyl-CoA carboxylase beta.	Stearoyl-CoA desaturase; Belongs to the fatty acid desaturase type 1 family.	0.463
ACACB	SREBF1	ENSRBIP00000035944	ENSRBIP00000000450	Acetyl-CoA carboxylase beta.	Sterol regulatory element binding transcription factor 1.	0.546
ADGRD1	KPNB1	ENSRBIP00000028558	ENSRBIP00000000461	Adhesion G protein-coupled receptor D1; Belongs to the G-protein coupled receptor 2 family.	Karyopherin subunit beta 1.	0.929
CARM1	CREBBP	ENSRBIP00000010739	ENSRBIP00000030593	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	CREB binding protein.	0.899
CARM1	FDFT1	ENSRBIP00000010739	ENSRBIP00000039124	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Farnesyl-diphosphate farnesyltransferase 1.	0.427
CARM1	HELZ2	ENSRBIP00000010739	ENSRBIP00000042854	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Helicase with zinc finger 2.	0.642
CARM1	MED1	ENSRBIP00000010739	ENSRBIP00000014931	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.941
CARM1	NCOA1	ENSRBIP00000010739	ENSRBIP00000022859	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator.	0.832
CARM1	NCOA2	ENSRBIP00000010739	ENSRBIP00000039622	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator.	0.867
CARM1	NCOA6	ENSRBIP00000010739	ENSRBIP00000027786	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Nuclear receptor coactivator 6.	0.480
CARM1	RXRA	ENSRBIP00000010739	ENSRBIP00000038762	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Retinoid X receptor alpha.	0.461
CARM1	TBL1X	ENSRBIP00000010739	ENSRBIP00000008765	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Transducin beta like 1 X-linked.	0.462
CARM1	TBL1XR1	ENSRBIP00000010739	ENSRBIP00000005900	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Transducin beta like 1 X-linked receptor 1.	0.462
CARM1	TGS1	ENSRBIP00000010739	ENSRBIP00000036570	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	Trimethylguanosine synthase 1.	0.477
CHD9	ENSRBIP00000012004	ENSRBIP00000023318	ENSRBIP00000012004	Uncharacterized protein.	Uncharacterized protein.	0.893
CHD9	PPARA	ENSRBIP00000023318	ENSRBIP00000007565	Uncharacterized protein.	Peroxisome proliferator activated receptor alpha.	0.414
CREBBP	CARM1	ENSRBIP00000030593	ENSRBIP00000010739	CREB binding protein.	Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.899
CREBBP	HELZ2	ENSRBIP00000030593	ENSRBIP00000042854	CREB binding protein.	Helicase with zinc finger 2.	0.778