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ENSRBIP00000035163 ENSRBIP00000035163 MAPK11 MAPK11 MAPKAPK2 MAPKAPK2 CREB1 CREB1 LOC108525504 LOC108525504 MEF2C MEF2C SOS1 SOS1 EP300 EP300 DNM1 DNM1 SGK1 SGK1 MAPK13 MAPK13 ENSRBIP00000032719 ENSRBIP00000032719 RALGDS RALGDS DUSP4 DUSP4 RALA RALA PCSK5 PCSK5 GAB1 GAB1 ID3 ID3 DNAL4 DNAL4 CSDE1 CSDE1 ID1 ID1 CRKL CRKL ADCYAP1R1 ADCYAP1R1 PCSK6 PCSK6 FRS2 FRS2 CSDE1-2 CSDE1-2 MEF2D MEF2D MAPK14 MAPK14 PTPN11 PTPN11 RALB RALB KRAS KRAS MAPK1 MAPK1 ENSRBIP00000026419 ENSRBIP00000026419 TRIB1 TRIB1 DNM2 DNM2 FOS FOS ADORA2A ADORA2A CDK5 CDK5 LOC108515310 LOC108515310 PCSK4 PCSK4 RAPGEF1 RAPGEF1 ENSRBIP00000023060 ENSRBIP00000023060 FOSL1 FOSL1 FURIN FURIN KIDINS220 KIDINS220 DNM3 DNM3 HRAS HRAS BRAF BRAF RELCH RELCH ENSRBIP00000020927 ENSRBIP00000020927 NTF3 NTF3 FNDC3A FNDC3A ADCYAP1 ADCYAP1 NELFB NELFB TIAM1 TIAM1 MAPK15 MAPK15 NTRK3 NTRK3 PIK3CA PIK3CA AP2A1 AP2A1 ENSRBIP00000016878 ENSRBIP00000016878 PPP2CB PPP2CB IRS2 IRS2 GRB2 GRB2 AP2B1 AP2B1 DUSP3 DUSP3 FRS3 FRS3 EGR2 EGR2 ENSRBIP00000015185 ENSRBIP00000015185 DOCK3 DOCK3 MAP2K1 MAP2K1 SHC4 SHC4 PIK3R2 PIK3R2 RIT2 RIT2 RPS6KA3 RPS6KA3 ATF1 ATF1 SH3GL3 SH3GL3 REST REST IRS1 IRS1 PIK3CB PIK3CB MAPKAPK3 MAPKAPK3 CDK5R1 CDK5R1 MEF2A MEF2A MAP2K2 MAP2K2 ENSRBIP00000011319 ENSRBIP00000011319 ID4 ID4 FNDC3B FNDC3B AP2A2 AP2A2 ASCL1 ASCL1 PPP2R1A PPP2R1A SHC2 SHC2 FOSB FOSB ENSRBIP00000009767 ENSRBIP00000009767 RPS6KA1 RPS6KA1 TCF12 TCF12 VRK3 VRK3 STAT3 STAT3 MAPK12 MAPK12 BDNF BDNF PPP2R1B PPP2R1B SH3GL2 SH3GL2 PPP2R5D PPP2R5D ENSRBIP00000006659 ENSRBIP00000006659 NAB1 NAB1 ELK1 ELK1 ERAS ERAS FYN FYN EGR3 EGR3 ASCL2 ASCL2 NTF4 NTF4 RPS6KA2 RPS6KA2 EGR1 EGR1 RAP1A RAP1A TRIB2 TRIB2 DUSP7 DUSP7 F3 F3 SRC SRC ENSRBIP00000002079 ENSRBIP00000002079 CLTA CLTA AP2M1 AP2M1 TPH1 TPH1 PIK3R1 PIK3R1 CRK CRK ARC ARC MAPK3 MAPK3 LYL1 LYL1 SRF SRF CDK5R2 CDK5R2 PPP2CA PPP2CA ID2 ID2 EGR4 EGR4 GRIN2B GRIN2B SHC3 SHC3 SHC1 SHC1 NGF NGF ENSRBIP00000040717 ENSRBIP00000040717 PTPRS PTPRS NTRK1 NTRK1 FNBP4 FNBP4 NRAS NRAS CREM CREM NAB2 NAB2 CLTC CLTC PLCG1 PLCG1 MAPK7 MAPK7 PTPRO PTPRO MAP2K5 MAP2K5 RRAD RRAD PPP4R4 PPP4R4 NTRK2 NTRK2 PPP4R1 PPP4R1 RPS6KA5 RPS6KA5 AP2S1 AP2S1 ATF2 ATF2 CHD4 CHD4 DUSP6 DUSP6 RIT1 RIT1 YWHAB YWHAB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSRBIP00000035163B2-adapt-app_C domain-containing protein. (224 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPKAPK2MAPK activated protein kinase 2. (392 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
LOC108525504Uncharacterized protein. (70 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
EP300E1A binding protein p300. (2296 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (863 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ENSRBIP00000032719SH2 domain-containing protein. (203 aa)
RALGDSUncharacterized protein. (918 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
RALARAS like proto-oncogene A. (206 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1860 aa)
GAB1GRB2 associated binding protein 1. (722 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
DNAL4Dynein light chain. (105 aa)
CSDE1Uncharacterized protein. (818 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
ADCYAP1R1ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family. (577 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (921 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
CSDE1-2Uncharacterized protein. (820 aa)
MEF2DMyocyte enhancer factor 2D. (523 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
RALBRAS like proto-oncogene B. (212 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
ENSRBIP00000026419Uncharacterized protein. (249 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (768 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
LOC108515310WRNPLPNID domain-containing protein. (954 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (724 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1095 aa)
ENSRBIP00000023060Protein kinase domain-containing protein. (120 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
FURINFurin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. (787 aa)
KIDINS220Kinase D interacting substrate 220. (1771 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (753 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa)
ENSRBIP00000020927Uncharacterized protein. (147 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (278 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (176 aa)
NELFBNegative elongation factor complex member B. (581 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
MAPK15Mitogen-activated protein kinase. (544 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (977 aa)
ENSRBIP00000016878Uncharacterized protein. (251 aa)
PPP2CBSerine/threonine-protein phosphatase. (304 aa)
IRS2Insulin receptor substrate 2. (904 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
AP2B1AP complex subunit beta. (951 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
FRS3Fibroblast growth factor receptor substrate 3. (491 aa)
EGR2Early growth response 2. (542 aa)
ENSRBIP00000015185ETS domain-containing protein. (421 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (2008 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SHC4SHC adaptor protein 4. (630 aa)
PIK3R2Uncharacterized protein. (626 aa)
RIT2Ras like without CAAX 2. (217 aa)
RPS6KA3Uncharacterized protein. (66 aa)
ATF1Activating transcription factor 1. (269 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (286 aa)
RESTRE1 silencing transcription factor. (1080 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (929 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (434 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
MEF2AMyocyte enhancer factor 2A. (511 aa)
MAP2K2Protein kinase domain-containing protein. (341 aa)
ENSRBIP00000011319Protein kinase domain-containing protein. (265 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (165 aa)
FNDC3BFibronectin type III domain containing 3B. (1178 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (894 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (234 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
SHC2Uncharacterized protein. (421 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
ENSRBIP00000009767Uncharacterized protein. (546 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
TCF12Transcription factor 12. (706 aa)
VRK3VRK serine/threonine kinase 3. (479 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MAPK12Mitogen-activated protein kinase. (369 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (315 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
ENSRBIP00000006659Protein kinase domain-containing protein. (275 aa)
NAB1NGFI-A binding protein 1. (487 aa)
ELK1ETS domain-containing protein. (428 aa)
ERASES cell expressed Ras. (233 aa)
FYNTyrosine-protein kinase. (537 aa)
EGR3Early growth response 3. (387 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
F3Coagulation factor III, tissue factor. (296 aa)
SRCTyrosine-protein kinase. (627 aa)
ENSRBIP00000002079Uncharacterized protein. (202 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (248 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (458 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
ARCActivity regulated cytoskeleton associated protein. (396 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
LYL1LYL1 basic helix-loop-helix family member. (280 aa)
SRFSerum response factor. (508 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
EGR4Early growth response 4. (588 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
SHC3SHC adaptor protein 3. (596 aa)
SHC1SHC adaptor protein 1. (584 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
ENSRBIP00000040717Uncharacterized protein. (100 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1739 aa)
NTRK1Tyrosine-protein kinase receptor. (816 aa)
FNBP4Formin binding protein 4. (925 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
CREMcAMP responsive element modulator. (330 aa)
NAB2NGFI-A binding protein 2. (525 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1681 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1216 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (297 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (807 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (930 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (684 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (158 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (429 aa)
CHD4Uncharacterized protein. (1906 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
RIT1Ras like without CAAX 1. (164 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (246 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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