STRINGSTRING
POLA2 POLA2 DNA2 DNA2 ENSRBIP00000034985 ENSRBIP00000034985 RFC1 RFC1 RPA3 RPA3 POT1 POT1 TERF1 TERF1 PRIM2 PRIM2 STN1 STN1 PRIM1 PRIM1 TERF2 TERF2 RFC5 RFC5 RFC4 RFC4 POLD2 POLD2 ENSRBIP00000025761 ENSRBIP00000025761 RPA1 RPA1 POLD4 POLD4 DSCC1 DSCC1 RFC2 RFC2 TINF2 TINF2 CTC1 CTC1 ACD ACD RFC3 RFC3 RCBTB1 RCBTB1 TERF2IP TERF2IP POLD1 POLD1 WRN WRN ENSRBIP00000013617 ENSRBIP00000013617 BLM BLM RCBTB2 RCBTB2 PCNA PCNA CHTF8 CHTF8 CHTF18 CHTF18 FEN1 FEN1 TEN1 TEN1 POLD3 POLD3 LIG1 LIG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLA2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa)
DNA2DNA replication helicase/nuclease 2. (1047 aa)
ENSRBIP00000034985TINF2_N domain-containing protein. (339 aa)
RFC1Replication factor C subunit 1. (1114 aa)
RPA3Replication protein A3. (121 aa)
POT1Protection of telomeres 1. (633 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (406 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (486 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
PRIM1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (420 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (421 aa)
RFC5Replication factor C subunit 5. (309 aa)
RFC4Replication factor C subunit 4. (362 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
ENSRBIP00000025761TINF2_N domain-containing protein. (517 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
POLD4Uncharacterized protein. (107 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (416 aa)
RFC2Replication factor C subunit 2. (352 aa)
TINF2TINF2_N domain-containing protein. (451 aa)
CTC1CST telomere replication complex component 1. (1217 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (528 aa)
RFC3Replication factor C subunit 3. (356 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
TERF2IPTERF2 interacting protein. (400 aa)
POLD1DNA polymerase. (1124 aa)
WRNWRN RecQ like helicase. (1394 aa)
ENSRBIP00000013617Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (245 aa)
BLMBLM RecQ like helicase. (1396 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CHTF8Chromosome transmission fidelity factor 8. (121 aa)
CHTF18Chromosome transmission fidelity factor 18. (999 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
TEN1Uncharacterized protein. (123 aa)
POLD3Uncharacterized protein. (454 aa)
LIG1DNA ligase. (928 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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