STRINGSTRING
FEN1 FEN1 TINF2 TINF2 DNA2 DNA2 ENSRBIP00000034985 ENSRBIP00000034985 RPA3 RPA3 POT1 POT1 TERF2 TERF2 POLD2 POLD2 ENSRBIP00000025761 ENSRBIP00000025761 RPA1 RPA1 POLD4 POLD4 TERF2IP TERF2IP POLD1 POLD1 WRN WRN ENSRBIP00000013617 ENSRBIP00000013617 PCNA PCNA ACD ACD TERF1 TERF1 POLD3 POLD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
TINF2TINF2_N domain-containing protein. (451 aa)
DNA2DNA replication helicase/nuclease 2. (1047 aa)
ENSRBIP00000034985TINF2_N domain-containing protein. (339 aa)
RPA3Replication protein A3. (121 aa)
POT1Protection of telomeres 1. (633 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (421 aa)
POLD2DNA polymerase delta 2, accessory subunit. (504 aa)
ENSRBIP00000025761TINF2_N domain-containing protein. (517 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
POLD4Uncharacterized protein. (107 aa)
TERF2IPTERF2 interacting protein. (400 aa)
POLD1DNA polymerase. (1124 aa)
WRNWRN RecQ like helicase. (1394 aa)
ENSRBIP00000013617Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (245 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ACDACD shelterin complex subunit and telomerase recruitment factor. (528 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (406 aa)
POLD3Uncharacterized protein. (454 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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