STRINGSTRING
STAM2 STAM2 SPRY1 SPRY1 RNF222 RNF222 ENSRBIP00000000419 ENSRBIP00000000419 EPN1 EPN1 RPS27A RPS27A LPXN LPXN ENSRBIP00000001317 ENSRBIP00000001317 PIK3R1 PIK3R1 ENSRBIP00000002079 ENSRBIP00000002079 SRC SRC ENSRBIP00000003802 ENSRBIP00000003802 ENSRBIP00000004187 ENSRBIP00000004187 ENSRBIP00000004747 ENSRBIP00000004747 LOC108540530 LOC108540530 LOC108529634 LOC108529634 HGS HGS ERAS ERAS SH3GL2 SH3GL2 CSK CSK EREG EREG UBA52 UBA52 ENSRBIP00000009767 ENSRBIP00000009767 FNDC3B FNDC3B PTPRT PTPRT STAM STAM ADAM10 ADAM10 ENSRBIP00000012514 ENSRBIP00000012514 EPGN EPGN SH3GL3 SH3GL3 ADAM17 ADAM17 TGFA TGFA ENSRBIP00000015347 ENSRBIP00000015347 PXN PXN ENSRBIP00000016224 ENSRBIP00000016224 LRIG2 LRIG2 EGF EGF GRB2 GRB2 PTPN12 PTPN12 ENSRBIP00000016878 ENSRBIP00000016878 TGFB1I1 TGFB1I1 PIK3CA PIK3CA SH3KBP1 SH3KBP1 FNDC3A FNDC3A ENSRBIP00000020228 ENSRBIP00000020228 HRAS HRAS SH3GL1 SH3GL1 ARHGEF7 ARHGEF7 ADAM12 ADAM12 LOC108524569 LOC108524569 ENSRBIP00000026419 ENSRBIP00000026419 KRAS KRAS ENSRBIP00000026615 ENSRBIP00000026615 PTPN11 PTPN11 BTC BTC PTPRM PTPRM CSDE1-2 CSDE1-2 ENSRBIP00000029173 ENSRBIP00000029173 PAG1 PAG1 HBEGF HBEGF CSDE1 CSDE1 GAB1 GAB1 PTPRT-2 PTPRT-2 ENSRBIP00000032719 ENSRBIP00000032719 SOS1 SOS1 LRIG3 LRIG3 PTPN3 PTPN3 AREG AREG AAMP AAMP EGFR EGFR CDC42 CDC42 ENSRBIP00000037737 ENSRBIP00000037737 CBL CBL ENSRBIP00000038277 ENSRBIP00000038277 PLCG1 PLCG1 LRIG1 LRIG1 NRAS NRAS ENSRBIP00000040717 ENSRBIP00000040717 SHC1 SHC1 EPS15 EPS15 EPS15L1 EPS15L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAM2Signal transducing adaptor molecule 2. (519 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
RNF222Ring finger protein 222. (220 aa)
ENSRBIP00000000419Uncharacterized protein. (191 aa)
EPN1Epsin 1. (662 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
LPXNLeupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). (386 aa)
ENSRBIP00000001317Ubiquitin-like domain-containing protein. (155 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ENSRBIP00000002079Uncharacterized protein. (202 aa)
SRCTyrosine-protein kinase. (627 aa)
ENSRBIP00000003802Ubiquitin-like domain-containing protein. (84 aa)
ENSRBIP00000004187Ubiquitin-like domain-containing protein. (153 aa)
ENSRBIP00000004747Ubiquitin-like domain-containing protein. (128 aa)
LOC108540530Ubiquitin A-52 residue ribosomal protein fusion product 1. (77 aa)
LOC108529634Ubiquitin-like domain-containing protein. (128 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
ERASES cell expressed Ras. (233 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (315 aa)
CSKTyrosine-protein kinase. (450 aa)
EREGEpiregulin. (169 aa)
UBA52Ubiquitin-like domain-containing protein. (232 aa)
ENSRBIP00000009767Uncharacterized protein. (546 aa)
FNDC3BFibronectin type III domain containing 3B. (1178 aa)
PTPRTProtein tyrosine phosphatase receptor type T. (1059 aa)
STAMSignal transducing adaptor molecule. (540 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
ENSRBIP00000012514Ubiquitin-like domain-containing protein. (121 aa)
EPGNEpithelial mitogen. (156 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (286 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
TGFATransforming growth factor alpha. (166 aa)
ENSRBIP00000015347Uncharacterized protein. (182 aa)
PXNPaxillin. (1083 aa)
ENSRBIP00000016224Uncharacterized protein. (184 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1065 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1208 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (763 aa)
ENSRBIP00000016878Uncharacterized protein. (251 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (444 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (372 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
ENSRBIP00000020228Uncharacterized protein. (132 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (368 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (755 aa)
ADAM12ADAM metallopeptidase domain 12. (938 aa)
LOC108524569Ubiquitin-like domain-containing protein. (141 aa)
ENSRBIP00000026419Uncharacterized protein. (249 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ENSRBIP00000026615Uncharacterized protein. (185 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
BTCBetacellulin. (129 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1496 aa)
CSDE1-2Uncharacterized protein. (820 aa)
ENSRBIP00000029173Ubiquitin-like domain-containing protein. (166 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (432 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
CSDE1Uncharacterized protein. (818 aa)
GAB1GRB2 associated binding protein 1. (722 aa)
PTPRT-2Uncharacterized protein. (339 aa)
ENSRBIP00000032719SH2 domain-containing protein. (203 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1119 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (913 aa)
AREGAmphiregulin. (264 aa)
AAMPAngio associated migratory cell protein. (434 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
CDC42Uncharacterized protein. (191 aa)
ENSRBIP00000037737annotation not available (191 aa)
CBLCbl proto-oncogene. (802 aa)
ENSRBIP00000038277Uncharacterized protein. (843 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1090 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
ENSRBIP00000040717Uncharacterized protein. (100 aa)
SHC1SHC adaptor protein 1. (584 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (899 aa)
EPS15L1Uncharacterized protein. (899 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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