STRINGSTRING
SGK1 SGK1 EP300 EP300 DUSP7 DUSP7 TRIB2 TRIB2 EGR1 EGR1 RPS6KA2 RPS6KA2 ASCL2 ASCL2 EGR3 EGR3 ELK1 ELK1 NAB1 NAB1 ENSRBIP00000006659 ENSRBIP00000006659 PPP2R5D PPP2R5D PPP2R1B PPP2R1B VRK3 VRK3 TCF12 TCF12 RPS6KA1 RPS6KA1 FOSB FOSB PPP2R1A PPP2R1A ASCL1 ASCL1 ID4 ID4 MEF2A MEF2A CDK5R1 CDK5R1 REST REST SH3GL3 SH3GL3 ATF1 ATF1 RPS6KA3 RPS6KA3 ENSRBIP00000015185 ENSRBIP00000015185 EGR2 EGR2 DUSP3 DUSP3 MAPK1 MAPK1 TRIB1 TRIB1 MAPK14 MAPK14 MEF2C MEF2C LOC108525504 LOC108525504 CREB1 CREB1 MAPKAPK2 MAPKAPK2 DNM2 DNM2 FOS FOS CDK5 CDK5 LOC108515310 LOC108515310 FOSL1 FOSL1 RELCH RELCH MAPK11 MAPK11 DUSP6 DUSP6 CHD4 CHD4 ATF2 ATF2 RPS6KA5 RPS6KA5 PPP4R1 PPP4R1 PPP4R4 PPP4R4 RRAD RRAD MAPK7 MAPK7 NAB2 NAB2 PPP2CA PPP2CA CREM CREM FNBP4 FNBP4 EGR4 EGR4 ID2 ID2 CDK5R2 CDK5R2 SRF SRF LYL1 LYL1 MAPK3 MAPK3 ARC ARC TPH1 TPH1 F3 F3 MEF2D MEF2D ID1 ID1 ID3 ID3 DUSP4 DUSP4 ENSRBIP00000020927 ENSRBIP00000020927 MAPK15 MAPK15 PPP2CB PPP2CB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SGK1Non-specific serine/threonine protein kinase. (526 aa)
EP300E1A binding protein p300. (2296 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (541 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
EGR3Early growth response 3. (387 aa)
ELK1ETS domain-containing protein. (428 aa)
NAB1NGFI-A binding protein 1. (487 aa)
ENSRBIP00000006659Protein kinase domain-containing protein. (275 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
VRK3VRK serine/threonine kinase 3. (479 aa)
TCF12Transcription factor 12. (706 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (234 aa)
ID4Inhibitor of DNA binding 4, HLH protein. (165 aa)
MEF2AMyocyte enhancer factor 2A. (511 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
RESTRE1 silencing transcription factor. (1080 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (286 aa)
ATF1Activating transcription factor 1. (269 aa)
RPS6KA3Uncharacterized protein. (66 aa)
ENSRBIP00000015185ETS domain-containing protein. (421 aa)
EGR2Early growth response 2. (542 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
TRIB1Tribbles pseudokinase 1. (372 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
LOC108525504Uncharacterized protein. (70 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MAPKAPK2MAPK activated protein kinase 2. (392 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (768 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
LOC108515310WRNPLPNID domain-containing protein. (954 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
CHD4Uncharacterized protein. (1906 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (429 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (684 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (930 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (807 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (297 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
NAB2NGFI-A binding protein 2. (525 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CREMcAMP responsive element modulator. (330 aa)
FNBP4Formin binding protein 4. (925 aa)
EGR4Early growth response 4. (588 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (367 aa)
SRFSerum response factor. (508 aa)
LYL1LYL1 basic helix-loop-helix family member. (280 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
ARCActivity regulated cytoskeleton associated protein. (396 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
F3Coagulation factor III, tissue factor. (296 aa)
MEF2DMyocyte enhancer factor 2D. (523 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
ENSRBIP00000020927Uncharacterized protein. (147 aa)
MAPK15Mitogen-activated protein kinase. (544 aa)
PPP2CBSerine/threonine-protein phosphatase. (304 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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