STRINGSTRING
NR1D1 NR1D1 MED29 MED29 CLOCK CLOCK NCOR1 NCOR1 FHL3 FHL3 ENSRBIP00000035740 ENSRBIP00000035740 SP1 SP1 ANGPTL4 ANGPTL4 HMGCS1 HMGCS1 TGS1 TGS1 PPARG PPARG MED10 MED10 TIAM2 TIAM2 MED27 MED27 NRF1 NRF1 RXRA RXRA NFYC NFYC FDFT1 FDFT1 NCOA2 NCOA2 FHL2 FHL2 CYP1A1 CYP1A1 MAP7D2 MAP7D2 ARNT ARNT MED11 MED11 HELZ2 HELZ2 MED8 MED8 ENSRBIP00000043357 ENSRBIP00000043357 TNFRSF21 TNFRSF21 SREBF1 SREBF1 NR1H3 NR1H3 G0S2 G0S2 MED7 MED7 ENSRBIP00000002260 ENSRBIP00000002260 MED22 MED22 NPAS2 NPAS2 MED6 MED6 MED23 MED23 MED15 MED15 ARNT2 ARNT2 GPS2 GPS2 ANKRD1 ANKRD1 GRHL2 GRHL2 RORA RORA GRHL1 GRHL1 TBL1XR1 TBL1XR1 MED20 MED20 SIN3B SIN3B MED9 MED9 PPARA PPARA SREBF2 SREBF2 TBL1X TBL1X CD36 CD36 CARM1 CARM1 MED25 MED25 BCLAF1 BCLAF1 ENSRBIP00000012004 ENSRBIP00000012004 ACADM ACADM PLIN2 PLIN2 SLC27A1 SLC27A1 NCOA3 NCOA3 MED26 MED26 CPT2 CPT2 TXNRD1 TXNRD1 THRAP3 THRAP3 CYP7A1 CYP7A1 NFYA NFYA MED1 MED1 LOC108532627 LOC108532627 APOA5 APOA5 ENSRBIP00000015311 ENSRBIP00000015311 ENSRBIP00000015912 ENSRBIP00000015912 PPARGC1A PPARGC1A MED21 MED21 APOA2 APOA2 MED18 MED18 MAP7D1 MAP7D1 HMGCS2 HMGCS2 ARNTL ARNTL PPARG-2 PPARG-2 NR1H4 NR1H4 CCNC CCNC MED30 MED30 MTF1 MTF1 CDK19 CDK19 FHL5 FHL5 ME1 ME1 GLIPR1 GLIPR1 ESRRA ESRRA AHRR AHRR ENSRBIP00000022219 ENSRBIP00000022219 ACSL1 ACSL1 NR1H2 NR1H2 NCOA1 NCOA1 CHD9 CHD9 SULT2A1 SULT2A1 ABCA1 ABCA1 ALAS1 ALAS1 MED28 MED28 PASD1 PASD1 PPARGC1B PPARGC1B MED16 MED16 RGL1 RGL1 ENSRBIP00000026006 ENSRBIP00000026006 MED4 MED4 ACOX1 ACOX1 HMGCR HMGCR MED31 MED31 ENSRBIP00000026924 ENSRBIP00000026924 FAM120B FAM120B MED13 MED13 FADS1 FADS1 NCOA6 NCOA6 PEX11A PEX11A ENSRBIP00000028880 ENSRBIP00000028880 MED19 MED19 NCOR2 NCOR2 MED14 MED14 MED24 MED24 AGT AGT FABP1 FABP1 CREBBP CREBBP C7orf57 C7orf57 ANKRD2 ANKRD2 MED12 MED12 RXRB RXRB SMARCD3 SMARCD3 TRIB3 TRIB3 MED13L MED13L HDAC3 HDAC3 EP300 EP300 TXNRD3 TXNRD3 AHR AHR CDK8 CDK8 NFYB NFYB MED17 MED17 SIN3A SIN3A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
MED29Mediator complex subunit 29. (221 aa)
CLOCKClock circadian regulator. (847 aa)
NCOR1Nuclear receptor corepressor 1. (2441 aa)
FHL3Four and a half LIM domains 3. (280 aa)
ENSRBIP00000035740Uncharacterized protein. (125 aa)
SP1Sp1 transcription factor. (769 aa)
ANGPTL4Angiopoietin like 4. (368 aa)
HMGCS13-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
TGS1Trimethylguanosine synthase 1. (843 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (298 aa)
MED10Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (135 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1713 aa)
MED27Mediator complex subunit 27. (311 aa)
NRF1Nuclear respiratory factor 1. (499 aa)
RXRARetinoid X receptor alpha. (492 aa)
NFYCNuclear transcription factor Y subunit gamma. (439 aa)
FDFT1Farnesyl-diphosphate farnesyltransferase 1. (468 aa)
NCOA2Nuclear receptor coactivator. (1475 aa)
FHL2Four and a half LIM domains 2. (389 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (512 aa)
MAP7D2MAP7 domain containing 2. (791 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
MED11Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (93 aa)
HELZ2Helicase with zinc finger 2. (2649 aa)
MED8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (338 aa)
ENSRBIP00000043357Uncharacterized protein. (714 aa)
TNFRSF21TNF receptor superfamily member 21. (655 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1047 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (441 aa)
G0S2G0/G1 switch protein 2; Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers. (103 aa)
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (232 aa)
ENSRBIP00000002260Btz domain-containing protein. (803 aa)
MED22Mediator complex subunit 22. (200 aa)
NPAS2Neuronal PAS domain protein 2. (824 aa)
MED6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (257 aa)
MED23Mediator complex subunit 23. (1374 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (710 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (723 aa)
GPS2G protein pathway suppressor 2. (327 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
GRHL2Grainyhead like transcription factor 2. (625 aa)
RORARAR related orphan receptor A. (555 aa)
GRHL1Grainyhead like transcription factor 1. (619 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
MED20Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (212 aa)
SIN3BSIN3 transcription regulator family member B. (1351 aa)
MED9Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (146 aa)
PPARAPeroxisome proliferator activated receptor alpha. (468 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1138 aa)
TBL1XTransducin beta like 1 X-linked. (586 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (582 aa)
MED25Mediator complex subunit 25. (707 aa)
BCLAF1BCL2 associated transcription factor 1. (921 aa)
ENSRBIP00000012004Uncharacterized protein. (450 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (454 aa)
PLIN2Perilipin; Belongs to the perilipin family. (445 aa)
SLC27A1Solute carrier family 27 member 1. (651 aa)
NCOA3Nuclear receptor coactivator. (1418 aa)
MED26TFIIS N-terminal domain-containing protein. (600 aa)
CPT2Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (659 aa)
TXNRD1Glutaredoxin domain-containing protein. (647 aa)
THRAP3Thyroid hormone receptor associated protein 3. (946 aa)
CYP7A1Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family. (405 aa)
NFYANuclear transcription factor Y subunit alpha. (347 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1547 aa)
LOC108532627Hist_deacetyl domain-containing protein. (210 aa)
APOA5Apolipoprotein A5. (366 aa)
ENSRBIP00000015311Uncharacterized protein. (117 aa)
ENSRBIP00000015912Uncharacterized protein. (143 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (159 aa)
APOA2Apolipoprotein A2. (132 aa)
MED18Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (208 aa)
MAP7D1MAP7 domain containing 1. (901 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (594 aa)
PPARG-2Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (217 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (481 aa)
CCNCCyclin C; Belongs to the cyclin family. (265 aa)
MED30Mediator complex subunit 30. (178 aa)
MTF1Metal regulatory transcription factor 1. (753 aa)
CDK19Cyclin dependent kinase 19. (502 aa)
FHL5Four and a half LIM domains 5. (284 aa)
ME1Malic enzyme. (562 aa)
GLIPR1GLI pathogenesis related 1; Belongs to the CRISP family. (266 aa)
ESRRAUncharacterized protein. (400 aa)
AHRRUncharacterized protein. (718 aa)
ENSRBIP00000022219Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (77 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (721 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (461 aa)
NCOA1Nuclear receptor coactivator. (1433 aa)
CHD9Uncharacterized protein. (2416 aa)
SULT2A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (280 aa)
ABCA1ATP binding cassette subfamily A member 1. (2261 aa)
ALAS15-aminolevulinate synthase. (640 aa)
MED28Mediator complex subunit 28. (178 aa)
PASD1PAS domain containing repressor 1. (675 aa)
PPARGC1BPPARG coactivator 1 beta. (1024 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (877 aa)
RGL1Ral guanine nucleotide dissociation stimulator like 1. (803 aa)
ENSRBIP00000026006Uncharacterized protein. (480 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (226 aa)
ACOX1Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (642 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
MED31Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (131 aa)
ENSRBIP00000026924CBFD_NFYB_HMF domain-containing protein. (184 aa)
FAM120BFamily with sequence similarity 120B. (866 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2143 aa)
FADS1Fatty acid desaturase 1. (501 aa)
NCOA6Nuclear receptor coactivator 6. (2068 aa)
PEX11APeroxisomal biogenesis factor 11 alpha. (207 aa)
ENSRBIP00000028880Uncharacterized protein. (375 aa)
MED19Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (261 aa)
NCOR2Nuclear receptor corepressor 2. (2488 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1196 aa)
MED24Mediator complex subunit 24. (1028 aa)
AGTAngiotensinogen; Belongs to the serpin family. (472 aa)
FABP1Fatty acid binding protein 1. (127 aa)
CREBBPCREB binding protein. (2422 aa)
C7orf57Chromosome 7 open reading frame 57. (323 aa)
ANKRD2Ankyrin repeat domain 2. (237 aa)
MED12Mediator complex subunit 12. (2055 aa)
RXRBRetinoid X receptor beta. (508 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (501 aa)
TRIB3Tribbles pseudokinase 3. (385 aa)
MED13LMediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2050 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
EP300E1A binding protein p300. (2296 aa)
TXNRD3Thioredoxin reductase 3; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (685 aa)
AHRUncharacterized protein. (833 aa)
CDK8Cyclin dependent kinase 8; Belongs to the protein kinase superfamily. (482 aa)
NFYBCBFD_NFYB_HMF domain-containing protein. (208 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (652 aa)
SIN3ASIN3 transcription regulator family member A. (1228 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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