89 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GNB5	G protein subunit beta 5. (403 aa)
	PLXNB1	Plexin B1. (2130 aa)
	SOS2	SOS Ras/Rho guanine nucleotide exchange factor 2. (1268 aa)
	VAV3	Uncharacterized protein. (287 aa)
	GNGT2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (101 aa)
	TIAM2	T cell lymphoma invasion and metastasis 2. (1713 aa)
	RASGRF2	Ras protein specific guanine nucleotide releasing factor 2. (1188 aa)
	ADRA1A	Adrenoceptor alpha 1A. (455 aa)
	ROCK2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1387 aa)
	GNG10	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (62 aa)
	ABR	ABR activator of RhoGEF and GTPase. (859 aa)
	ARHGEF10L	Rho guanine nucleotide exchange factor 10 like. (1277 aa)
	NGEF	Neuronal guanine nucleotide exchange factor. (704 aa)
	RHOB	Ras homolog family member B. (196 aa)
	PREX1	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1629 aa)
	ARHGEF6	DH domain-containing protein. (402 aa)
	PLEKHG5	Pleckstrin homology and RhoGEF domain containing G5. (1083 aa)
	ECT2L	Epithelial cell transforming 2 like. (904 aa)
	MCF2L	MCF.2 cell line derived transforming sequence like. (1211 aa)
	VAV2	Vav guanine nucleotide exchange factor 2. (783 aa)
	ARHGEF37	Rho guanine nucleotide exchange factor 37. (613 aa)
	ARHGEF3	Rho guanine nucleotide exchange factor 3. (578 aa)
	ENSRBIP00000000056	Uncharacterized protein. (547 aa)
	ARHGEF15	Rho guanine nucleotide exchange factor 15. (831 aa)
	GNB4	G protein subunit beta 4. (340 aa)
	TGM6	Transglutaminase 6. (706 aa)
	ENSRBIP00000007423	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
	ARHGEF40	Rho guanine nucleotide exchange factor 40. (1520 aa)
	PLEKHG2	Pleckstrin homology and RhoGEF domain containing G2. (1377 aa)
	OBSCN	Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF. (8476 aa)
	ARHGEF39	Rho guanine nucleotide exchange factor 39. (335 aa)
	KALRN	Kalirin RhoGEF kinase. (2940 aa)
	ARHGEF10	Rho guanine nucleotide exchange factor 10. (1361 aa)
	ARHGEF17	Rho guanine nucleotide exchange factor 17. (2065 aa)
	GNA13	G protein subunit alpha 13. (353 aa)
	ADRA1D	Adrenoceptor alpha 1D. (491 aa)
	BTK	Tyrosine-protein kinase. (673 aa)
	ADRA1B	Adrenoceptor alpha 1B. (500 aa)
	GNG7	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	ROCK1	Rho associated coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1341 aa)
	GNG13	G protein subunit gamma 13. (67 aa)
	ARHGEF16	Rho guanine nucleotide exchange factor 16. (709 aa)
	ENSRBIP00000011770	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (66 aa)
	FGD3	FYVE, RhoGEF and PH domain containing 3. (672 aa)
	ENSRBIP00000013012	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	ARHGEF19	Rho guanine nucleotide exchange factor 19. (809 aa)
	ENSRBIP00000013802	Uncharacterized protein. (354 aa)
	ARHGEF9	Cdc42 guanine nucleotide exchange factor 9. (316 aa)
	FGD4	FYVE, RhoGEF and PH domain containing 4. (917 aa)
	ARHGEF5	Rho guanine nucleotide exchange factor 5. (1579 aa)
	NET1	Neuroepithelial cell transforming 1. (596 aa)
	GNB2	G protein subunit beta 2. (368 aa)
	GNB3	G protein subunit beta 3. (340 aa)
	TGM3	TGc domain-containing protein. (693 aa)
	GNG4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	GNG5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1591 aa)
	GNA12	G protein subunit alpha 12. (322 aa)
	GNG11	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	FGD1	FYVE, RhoGEF and PH domain containing 1. (939 aa)
	ARHGEF33	Rho guanine nucleotide exchange factor 33. (853 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (102 aa)
	ARHGEF2	Rho/Rac guanine nucleotide exchange factor 2. (1003 aa)
	SESTD1	SEC14 and spectrin domain containing 1. (696 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (755 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1561 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1536 aa)
	TBXA2R	Thromboxane A2 receptor. (379 aa)
	ARHGEF4	Uncharacterized protein. (1813 aa)
	GNG3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	ARHGEF1	Rho guanine nucleotide exchange factor 1. (968 aa)
	ARHGEF38	DH domain-containing protein. (219 aa)
	TRIO	Trio Rho guanine nucleotide exchange factor. (3073 aa)
	ECT2	Epithelial cell transforming 2. (893 aa)
	ENSRBIP00000029649	DH domain-containing protein. (251 aa)
	MCF2L2	MCF.2 cell line derived transforming sequence-like 2. (1114 aa)
	ITSN1	Intersectin 1. (1720 aa)
	AKAP13	A-kinase anchoring protein 13. (2816 aa)
	GNG12	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	ARHGEF26	Rho guanine nucleotide exchange factor 26. (935 aa)
	GNB1	G protein subunit beta 1. (340 aa)
	GNG8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
	MCF2	MCF.2 cell line derived transforming sequence. (864 aa)
	FGD2	FYVE, RhoGEF and PH domain containing 2. (656 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
	ARHGEF18	Uncharacterized protein. (1173 aa)
	ENSRBIP00000034184	G protein gamma domain-containing protein. (68 aa)
	RHOC	Ras homolog family member C. (193 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (843 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABR	ARHGEF18	ENSRBIP00000042797	ENSRBIP00000033819	ABR activator of RhoGEF and GTPase.	Uncharacterized protein.	0.628
ABR	ENSRBIP00000013802	ENSRBIP00000042797	ENSRBIP00000013802	ABR activator of RhoGEF and GTPase.	Uncharacterized protein.	0.504
ABR	RHOB	ENSRBIP00000042797	ENSRBIP00000005292	ABR activator of RhoGEF and GTPase.	Ras homolog family member B.	0.469
ABR	RHOC	ENSRBIP00000042797	ENSRBIP00000034378	ABR activator of RhoGEF and GTPase.	Ras homolog family member C.	0.469
ABR	TIAM1	ENSRBIP00000042797	ENSRBIP00000018873	ABR activator of RhoGEF and GTPase.	T cell lymphoma invasion and metastasis 1.	0.477
ADRA1A	ADRA1B	ENSRBIP00000040631	ENSRBIP00000010087	Adrenoceptor alpha 1A.	Adrenoceptor alpha 1B.	0.430
ADRA1A	ARHGEF1	ENSRBIP00000040631	ENSRBIP00000026726	Adrenoceptor alpha 1A.	Rho guanine nucleotide exchange factor 1.	0.411
ADRA1A	ARHGEF11	ENSRBIP00000040631	ENSRBIP00000024851	Adrenoceptor alpha 1A.	Rho guanine nucleotide exchange factor 11.	0.411
ADRA1A	ARHGEF12	ENSRBIP00000040631	ENSRBIP00000024903	Adrenoceptor alpha 1A.	Rho guanine nucleotide exchange factor 12.	0.521
ADRA1A	ENSRBIP00000007423	ENSRBIP00000040631	ENSRBIP00000007423	Adrenoceptor alpha 1A.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.458
ADRA1A	ENSRBIP00000011770	ENSRBIP00000040631	ENSRBIP00000011770	Adrenoceptor alpha 1A.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.460
ADRA1A	ENSRBIP00000013012	ENSRBIP00000040631	ENSRBIP00000013012	Adrenoceptor alpha 1A.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.400
ADRA1A	GNA12	ENSRBIP00000040631	ENSRBIP00000019387	Adrenoceptor alpha 1A.	G protein subunit alpha 12.	0.961
ADRA1A	GNA13	ENSRBIP00000040631	ENSRBIP00000009729	Adrenoceptor alpha 1A.	G protein subunit alpha 13.	0.961
ADRA1A	GNB1	ENSRBIP00000040631	ENSRBIP00000032151	Adrenoceptor alpha 1A.	G protein subunit beta 1.	0.532
ADRA1A	GNB2	ENSRBIP00000040631	ENSRBIP00000016906	Adrenoceptor alpha 1A.	G protein subunit beta 2.	0.532
ADRA1A	GNB3	ENSRBIP00000040631	ENSRBIP00000017763	Adrenoceptor alpha 1A.	G protein subunit beta 3.	0.527
ADRA1A	GNB4	ENSRBIP00000040631	ENSRBIP00000006724	Adrenoceptor alpha 1A.	G protein subunit beta 4.	0.532
ADRA1A	GNB5	ENSRBIP00000040631	ENSRBIP00000034869	Adrenoceptor alpha 1A.	G protein subunit beta 5.	0.678
ADRA1A	GNG10	ENSRBIP00000040631	ENSRBIP00000040097	Adrenoceptor alpha 1A.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.458