STRINGSTRING
ESRP1 ESRP1 ENSRBIP00000032719 ENSRBIP00000032719 SOS1 SOS1 FGF5 FGF5 HNRNPM HNRNPM FGF18 FGF18 POLR2J POLR2J CBL CBL PLCG1 PLCG1 POLR2B POLR2B NRAS NRAS NCBP1 NCBP1 ENSRBIP00000040717 ENSRBIP00000040717 SHC1 SHC1 PTBP1 PTBP1 HRAS HRAS POLR2K POLR2K LOC108524569 LOC108524569 ENSRBIP00000026419 ENSRBIP00000026419 MAPK1 MAPK1 KRAS KRAS FGF7 FGF7 POLR2I POLR2I ENSRBIP00000020228 ENSRBIP00000020228 FNDC3A FNDC3A POLR2L POLR2L RBFOX2 RBFOX2 MKNK1 MKNK1 PIK3CA PIK3CA ENSRBIP00000017217 ENSRBIP00000017217 ENSRBIP00000016878 ENSRBIP00000016878 PPP2CB PPP2CB FGF16 FGF16 GRB2 GRB2 POLR2H POLR2H PTBP2 PTBP2 FRS3 FRS3 FGFR2 FGFR2 FGF3 FGF3 TIA1 TIA1 ENSRBIP00000012514 ENSRBIP00000012514 FGFBP1 FGFBP1 ENSRBIP00000011319 ENSRBIP00000011319 HNRNPA1 HNRNPA1 FNDC3B FNDC3B PPP2R1A PPP2R1A ENSRBIP00000009767 ENSRBIP00000009767 POLR2E POLR2E FGF1 FGF1 NCBP2 NCBP2 UBA52 UBA52 TIAL1 TIAL1 ENSRBIP00000006972 ENSRBIP00000006972 ENSRBIP00000006745 ENSRBIP00000006745 ERAS ERAS POLR2C POLR2C LOC108529634 LOC108529634 LOC108540530 LOC108540530 ESRP2 ESRP2 ENSRBIP00000004747 ENSRBIP00000004747 GTF2F2 GTF2F2 ENSRBIP00000004187 ENSRBIP00000004187 ENSRBIP00000003802 ENSRBIP00000003802 FGF20 FGF20 ENSRBIP00000003370 ENSRBIP00000003370 PTBP3 PTBP3 SRC SRC ENSRBIP00000002079 ENSRBIP00000002079 FGF4 FGF4 POLR2G POLR2G PIK3R1 PIK3R1 FGF10 FGF10 ENSRBIP00000001403 ENSRBIP00000001403 ENSRBIP00000001317 ENSRBIP00000001317 ENSRBIP00000000734 ENSRBIP00000000734 RPS27A RPS27A POLR2A POLR2A MAPK3 MAPK3 GTF2F1 GTF2F1 PTPN11 PTPN11 POLR2F POLR2F PPP2CA PPP2CA MKNK2 MKNK2 FGF23 FGF23 CSDE1-2 CSDE1-2 FGF22 FGF22 FGF8 FGF8 FRS2 FRS2 ENSRBIP00000029173 ENSRBIP00000029173 FGF9 FGF9 CSDE1 CSDE1 FGF6 FGF6 FGF2 FGF2 BRAF BRAF GAB1 GAB1 POLR2D POLR2D FGF17 FGF17 ENSRBIP00000032140 ENSRBIP00000032140
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ESRP1Epithelial splicing regulatory protein 1. (681 aa)
ENSRBIP00000032719SH2 domain-containing protein. (203 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
HNRNPMHeterogeneous nuclear ribonucleoprotein M. (664 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
POLR2JRNA_pol_L_2 domain-containing protein. (159 aa)
CBLCbl proto-oncogene. (802 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1156 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
NCBP1Nuclear cap binding protein subunit 1. (790 aa)
ENSRBIP00000040717Uncharacterized protein. (100 aa)
SHC1SHC adaptor protein 1. (584 aa)
PTBP1Polypyrimidine tract binding protein 1. (556 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
POLR2KRNA polymerase II subunit K. (58 aa)
LOC108524569Ubiquitin-like domain-containing protein. (141 aa)
ENSRBIP00000026419Uncharacterized protein. (249 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
ENSRBIP00000020228Uncharacterized protein. (132 aa)
FNDC3AFibronectin type III domain containing 3A. (1198 aa)
POLR2LRNA polymerase II subunit L. (67 aa)
RBFOX2RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (391 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (464 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
ENSRBIP00000017217Uncharacterized protein. (71 aa)
ENSRBIP00000016878Uncharacterized protein. (251 aa)
PPP2CBSerine/threonine-protein phosphatase. (304 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
POLR2HRNA polymerase II subunit H. (174 aa)
PTBP2Polypyrimidine tract binding protein 2. (504 aa)
FRS3Fibroblast growth factor receptor substrate 3. (491 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (239 aa)
TIA1TIA1 cytotoxic granule associated RNA binding protein. (321 aa)
ENSRBIP00000012514Ubiquitin-like domain-containing protein. (121 aa)
FGFBP1Fibroblast growth factor binding protein 1. (234 aa)
ENSRBIP00000011319Protein kinase domain-containing protein. (265 aa)
HNRNPA1Uncharacterized protein. (372 aa)
FNDC3BFibronectin type III domain containing 3B. (1178 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
ENSRBIP00000009767Uncharacterized protein. (546 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (166 aa)
UBA52Ubiquitin-like domain-containing protein. (232 aa)
TIAL1TIA1 cytotoxic granule associated RNA binding protein like 1. (392 aa)
ENSRBIP00000006972Uncharacterized protein. (194 aa)
ENSRBIP00000006745RRM domain-containing protein. (455 aa)
ERASES cell expressed Ras. (233 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
LOC108529634Ubiquitin-like domain-containing protein. (128 aa)
LOC108540530Ubiquitin A-52 residue ribosomal protein fusion product 1. (77 aa)
ESRP2Epithelial splicing regulatory protein 2. (711 aa)
ENSRBIP00000004747Ubiquitin-like domain-containing protein. (128 aa)
GTF2F2General transcription factor IIF subunit 2. (232 aa)
ENSRBIP00000004187Ubiquitin-like domain-containing protein. (153 aa)
ENSRBIP00000003802Ubiquitin-like domain-containing protein. (84 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
ENSRBIP00000003370Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (431 aa)
PTBP3Polypyrimidine tract binding protein 3. (505 aa)
SRCTyrosine-protein kinase. (627 aa)
ENSRBIP00000002079Uncharacterized protein. (202 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSRBIP00000001403Uncharacterized protein. (183 aa)
ENSRBIP00000001317Ubiquitin-like domain-containing protein. (155 aa)
ENSRBIP00000000734RRM domain-containing protein. (350 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1941 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (469 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
POLR2FRNA polymerase II subunit F. (150 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (465 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
CSDE1-2Uncharacterized protein. (820 aa)
FGF22Fibroblast growth factor 22; Belongs to the heparin-binding growth factors family. (147 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FRS2Fibroblast growth factor receptor substrate 2. (522 aa)
ENSRBIP00000029173Ubiquitin-like domain-containing protein. (166 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CSDE1Uncharacterized protein. (818 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (263 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (753 aa)
GAB1GRB2 associated binding protein 1. (722 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ENSRBIP00000032140Uncharacterized protein. (620 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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