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| | SIRT6 | Sirtuin 6. (355 aa) |
| | LOC108513418 | Histone H4. (103 aa) |
| | LOC108536802 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LIG3 | DNA ligase. (950 aa) |
| | H2BC5 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (277 aa) |
| | LOC108538182 | MPN domain-containing protein. (237 aa) |
| | LOC108544889 | Histone domain-containing protein; Belongs to the histone H2B family. (168 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1149 aa) |
| | POLH | DNA polymerase eta. (697 aa) |
| | RCBTB2 | RCC1 and BTB domain containing protein 2. (556 aa) |
| | LOC108513260 | SER_THR_PHOSPHATASE domain-containing protein. (120 aa) |
| | UBA52 | Ubiquitin-like domain-containing protein. (232 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | LOC108526191 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (112 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (419 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | LOC108513393 | Histone H2B type 1. (126 aa) |
| | RNF4 | Ring finger protein 4. (190 aa) |
| | RMI1 | RecQ mediated genome instability 1. (625 aa) |
| | ENSRBIP00000006844 | Uncharacterized protein. (72 aa) |
| | LOC108525434 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC108520651 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | LOC108513411-2 | Histone H2B type 1. (126 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (1226 aa) |
| | LOC108529634 | Ubiquitin-like domain-containing protein. (128 aa) |
| | HERC2 | HECT domain-containing protein. (507 aa) |
| | POLQ | DNA polymerase theta. (2717 aa) |
| | LOC108540530 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (77 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | LOC108513437 | Histone H4. (103 aa) |
| | H2BC13 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC108540122 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | UBE2NL | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa) |
| | LOC108513411 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSRBIP00000004795 | DUF4502 domain-containing protein. (197 aa) |
| | ENSRBIP00000004777 | Rad60-SLD domain-containing protein. (51 aa) |
| | ENSRBIP00000004747 | Ubiquitin-like domain-containing protein. (128 aa) |
| | ENSRBIP00000004187 | Ubiquitin-like domain-containing protein. (153 aa) |
| | LOC108513419 | Histone H4. (103 aa) |
| | LOC108520555 | Histone H4. (103 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (468 aa) |
| | ENSRBIP00000003802 | Ubiquitin-like domain-containing protein. (84 aa) |
| | LOC108525496 | Histone H4-like. (101 aa) |
| | ENSRBIP00000003512 | Small ubiquitin-related modifier. (95 aa) |
| | ENSRBIP00000003466 | Ubiquitin-like domain-containing protein. (128 aa) |
| | ENSRBIP00000003378 | Metallophos domain-containing protein. (233 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | LOC108530500-3 | Histone H4. (103 aa) |
| | ENSRBIP00000002862 | Uncharacterized protein. (276 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | UBE2I | Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (231 aa) |
| | LOC108530500-2 | Histone H4. (103 aa) |
| | TIMELESS | Timeless circadian regulator. (1208 aa) |
| | LOC108530500 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | LOC108513434 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | RAD51D | RAD51 paralog D. (347 aa) |
| | H2BC21 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSRBIP00000001317 | Ubiquitin-like domain-containing protein. (155 aa) |
| | LOC108533652 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | RPS27A | Ubiquitin-like domain-containing protein. (156 aa) |
| | LOC108512615 | Histone domain-containing protein; Belongs to the histone H2B family. (168 aa) |
| | BRCA2 | Uncharacterized protein. (386 aa) |
| | CDCA7L | Cell division cycle associated 7 like. (455 aa) |
| | LOC108515700 | Serine/threonine-protein phosphatase. (281 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa) |
| | RFC5 | Replication factor C subunit 5. (309 aa) |
| | ENSRBIP00000029173 | Ubiquitin-like domain-containing protein. (166 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1343 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (281 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa) |
| | SIRT7 | Sirtuin 7. (421 aa) |
| | CDK3 | Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (719 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1814 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | ENSRBIP00000033406 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa) |
| | RFC1 | Replication factor C subunit 1. (1114 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (531 aa) |
| | ENSRBIP00000033764 | Histone H2B; Belongs to the histone H2B family. (134 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (633 aa) |
| | PPP4R2 | Uncharacterized protein. (417 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (551 aa) |
| | ENSRBIP00000034615 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1047 aa) |
| | BRCC3 | MPN domain-containing protein. (297 aa) |
| | ENSRBIP00000035711 | RAD51_interact domain-containing protein. (282 aa) |
| | CCNA2 | Cyclin A2; Belongs to the cyclin family. (432 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (508 aa) |
| | ENSRBIP00000037358 | DUF1725 domain-containing protein. (64 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1527 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1368 aa) |
| | RFC3 | Replication factor C subunit 3. (356 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (570 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (676 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (771 aa) |
| | H2BC15 | Histone H2B; Belongs to the histone H2B family. (166 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (329 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (289 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1818 aa) |
| | ATRIP | ATR interacting protein. (790 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1050 aa) |
| | POLD3 | Uncharacterized protein. (454 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (898 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1943 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (377 aa) |
| | POLD1 | DNA polymerase. (1124 aa) |
| | ENSRBIP00000017948 | Ubiquitin-like domain-containing protein. (119 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (415 aa) |
| | ENSRBIP00000018131 | Histone H2B; Belongs to the histone H2B family. (129 aa) |
| | SUMO3 | Small ubiquitin-related modifier. (97 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (571 aa) |
| | RECQL4 | RecQ like helicase 4. (1197 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1281 aa) |
| | ENSRBIP00000019157 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (78 aa) |
| | SPIDR | DUF4503 domain-containing protein. (397 aa) |
| | SUMO2 | Ubiquitin-like domain-containing protein. (80 aa) |
| | ENSRBIP00000019958 | Uncharacterized protein. (231 aa) |
| | ENSRBIP00000020228 | Uncharacterized protein. (132 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (908 aa) |
| | RCBTB1 | RCC1 and BTB domain containing protein 1. (531 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | ENSRBIP00000020891 | Uncharacterized protein. (64 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2253 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (144 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (288 aa) |
| | SLX1A | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (404 aa) |
| | ENSRBIP00000023642 | Uncharacterized protein. (72 aa) |
| | RNF169 | Ring finger protein 169. (659 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (465 aa) |
| | RAD51B | RAD51 paralog B. (426 aa) |
| | RAD1 | Uncharacterized protein. (280 aa) |
| | POLD4 | Uncharacterized protein. (107 aa) |
| | LOC108524569 | Ubiquitin-like domain-containing protein. (141 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (117 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | EXO1 | Exonuclease 1. (827 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (504 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (492 aa) |
| | POLK | DNA polymerase kappa. (866 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa) |
| | RFC4 | Replication factor C subunit 4. (362 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (408 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | RMI2 | RecQ mediated genome instability 2. (150 aa) |
| | ENSRBIP00000015800 | Ubiquitin-like domain-containing protein. (132 aa) |
| | MDC1 | Mediator of DNA damage checkpoint 1. (2087 aa) |
| | WRN | WRN RecQ like helicase. (1394 aa) |
| | RAD51C | RAD51 paralog C. (376 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (907 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (347 aa) |
| | ENSRBIP00000014751 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (105 aa) |
| | TDRD3 | Tudor domain containing 3. (749 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (621 aa) |
| | ENSRBIP00000013688 | Uncharacterized protein. (232 aa) |
| | ENSRBIP00000013673 | Ubiquitin-like domain-containing protein. (132 aa) |
| | ENSRBIP00000013617 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (245 aa) |
| | CLSPN | Claspin. (1301 aa) |
| | RHNO1 | Uncharacterized protein. (240 aa) |
| | H2BC11 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | ENSRBIP00000012514 | Ubiquitin-like domain-containing protein. (121 aa) |
| | MEIOB | Meiosis specific with OB-fold. (449 aa) |
| | ENSRBIP00000011806 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa) |
| | BLM | BLM RecQ like helicase. (1396 aa) |
| | LOC108513411-3 | Histone H2B type 1. (126 aa) |
| | H3-4 | Histone H3; Belongs to the histone H3 family. (136 aa) |
