STRINGSTRING
BABAM2 BABAM2 XRCC5 XRCC5 TDP1 TDP1 TP53BP1 TP53BP1 MDC1 MDC1 ENSRBIP00000014751 ENSRBIP00000014751 PRKDC PRKDC H2BC11 H2BC11 H2BC3 H2BC3 ENSRBIP00000011806 ENSRBIP00000011806 LOC108513411-3 LOC108513411-3 H3-4 H3-4 ENSRBIP00000011182 ENSRBIP00000011182 LOC108513418 LOC108513418 LOC108536802 LOC108536802 H2BC5 H2BC5 LOC108538182 LOC108538182 LOC108544889 LOC108544889 LOC108526191 LOC108526191 LOC108513393 LOC108513393 LOC108525434 LOC108525434 LOC108520651 LOC108520651 LOC108513411-2 LOC108513411-2 LOC108512615 LOC108512615 LOC108533652 LOC108533652 DCLRE1C DCLRE1C RIF1 RIF1 H2BC21 H2BC21 ENSRBIP00000001755 ENSRBIP00000001755 LOC108513434 LOC108513434 HERC2 HERC2 H2BC1 H2BC1 LOC108513437 LOC108513437 H2BC13 H2BC13 LOC108540122 LOC108540122 UBE2NL UBE2NL LOC108513411 LOC108513411 LOC108513419 LOC108513419 LOC108520555 LOC108520555 RNF8 RNF8 LOC108525496 LOC108525496 ENSRBIP00000003378 ENSRBIP00000003378 LOC108530500-3 LOC108530500-3 ENSRBIP00000002862 ENSRBIP00000002862 H2BU1 H2BU1 LOC108530500-2 LOC108530500-2 LOC108530500 LOC108530500 TMEM182 TMEM182 H2BC15 H2BC15 BABAM1 BABAM1 BRCA1 BRCA1 NHEJ1 NHEJ1 ENSRBIP00000041364 ENSRBIP00000041364 DNTT DNTT BRCC3 BRCC3 PAXIP1 PAXIP1 ENSRBIP00000036862 ENSRBIP00000036862 POLM POLM PIAS4 PIAS4 ENSRBIP00000037358 ENSRBIP00000037358 NSD2 NSD2 ENSRBIP00000033406 ENSRBIP00000033406 ENSRBIP00000033764 ENSRBIP00000033764 UIMC1 UIMC1 LIG4 LIG4 CNPPD1 CNPPD1 XRCC6 XRCC6 RNF168 RNF168 KAT5 KAT5 ABRAXAS1 ABRAXAS1 TDP2 TDP2 NBN NBN RNF169 RNF169 XRCC4 XRCC4 UBE2V2 UBE2V2 POLL POLL MRE11 MRE11 SLC23A3 SLC23A3 ENSRBIP00000020891 ENSRBIP00000020891 ATM ATM ENSRBIP00000019157 ENSRBIP00000019157 BARD1 BARD1 RAD50 RAD50 ENSRBIP00000018131 ENSRBIP00000018131
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BABAM2BRISC and BRCA1 A complex member 2. (415 aa)
XRCC5X-ray repair cross complementing 5. (805 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (573 aa)
TP53BP1Tumor protein p53 binding protein 1. (1943 aa)
MDC1Mediator of DNA damage checkpoint 1. (2087 aa)
ENSRBIP00000014751UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (105 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSRBIP00000011806UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
LOC108513411-3Histone H2B type 1. (126 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
ENSRBIP00000011182Ku domain-containing protein. (328 aa)
LOC108513418Histone H4. (103 aa)
LOC108536802Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108538182MPN domain-containing protein. (237 aa)
LOC108544889Histone domain-containing protein; Belongs to the histone H2B family. (168 aa)
LOC108526191UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (112 aa)
LOC108513393Histone H2B type 1. (126 aa)
LOC108525434Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108520651UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LOC108513411-2Histone H2B type 1. (126 aa)
LOC108512615Histone domain-containing protein; Belongs to the histone H2B family. (168 aa)
LOC108533652Histone H2B; Belongs to the histone H2B family. (127 aa)
DCLRE1CDNA cross-link repair 1C. (689 aa)
RIF1Replication timing regulatory factor 1. (2444 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSRBIP00000001755Uncharacterized protein. (218 aa)
LOC108513434Histone H2B; Belongs to the histone H2B family. (126 aa)
HERC2HECT domain-containing protein. (507 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
LOC108513437Histone H4. (103 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108540122Histone H2B; Belongs to the histone H2B family. (126 aa)
UBE2NLUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
LOC108513411Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108513419Histone H4. (103 aa)
LOC108520555Histone H4. (103 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (468 aa)
LOC108525496Histone H4-like. (101 aa)
ENSRBIP00000003378Metallophos domain-containing protein. (233 aa)
LOC108530500-3Histone H4. (103 aa)
ENSRBIP00000002862Uncharacterized protein. (276 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108530500-2Histone H4. (103 aa)
LOC108530500Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
TMEM182Transmembrane protein 182. (228 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (166 aa)
BABAM1BRISC and BRCA1 A complex member 1. (329 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1818 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
ENSRBIP00000041364Ku domain-containing protein. (498 aa)
DNTTDNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (509 aa)
BRCC3MPN domain-containing protein. (297 aa)
PAXIP1PAX interacting protein 1. (1086 aa)
ENSRBIP00000036862Ku domain-containing protein. (567 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (494 aa)
PIAS4Protein inhibitor of activated STAT 4. (508 aa)
ENSRBIP00000037358DUF1725 domain-containing protein. (64 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1368 aa)
ENSRBIP00000033406UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
ENSRBIP00000033764Histone H2B; Belongs to the histone H2B family. (134 aa)
UIMC1Ubiquitin interaction motif containing 1. (719 aa)
LIG4DNA ligase. (901 aa)
CNPPD1Cyclin Pas1/PHO80 domain containing 1. (408 aa)
XRCC6X-ray repair cross complementing 6. (568 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (408 aa)
TDP2Tyrosyl-DNA phosphodiesterase 2. (358 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa)
RNF169Ring finger protein 169. (659 aa)
XRCC4X-ray repair cross complementing 4. (231 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (144 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
SLC23A3Solute carrier family 23 member 3. (610 aa)
ENSRBIP00000020891Uncharacterized protein. (64 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa)
ENSRBIP00000019157UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (78 aa)
BARD1BRCA1 associated RING domain 1. (771 aa)
RAD50Zinc-hook domain-containing protein. (1281 aa)
ENSRBIP00000018131Histone H2B; Belongs to the histone H2B family. (129 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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