STRINGSTRING
ENSRBIP00000015800 ENSRBIP00000015800 LOC108515700 LOC108515700 CDCA7L CDCA7L LOC108512615 LOC108512615 RPS27A RPS27A LOC108533652 LOC108533652 ENSRBIP00000001317 ENSRBIP00000001317 H2BC21 H2BC21 LOC108513434 LOC108513434 LOC108530500 LOC108530500 TIMELESS TIMELESS LOC108530500-2 LOC108530500-2 UBE2I UBE2I H2BU1 H2BU1 ENSRBIP00000002862 ENSRBIP00000002862 LOC108530500-3 LOC108530500-3 ENSRBIP00000003378 ENSRBIP00000003378 ENSRBIP00000003466 ENSRBIP00000003466 ENSRBIP00000003512 ENSRBIP00000003512 LOC108525496 LOC108525496 ENSRBIP00000003802 ENSRBIP00000003802 RNF8 RNF8 LOC108520555 LOC108520555 LOC108513419 LOC108513419 ENSRBIP00000004187 ENSRBIP00000004187 ENSRBIP00000004777 ENSRBIP00000004777 LOC108513411 LOC108513411 UBE2NL UBE2NL LOC108540122 LOC108540122 H2BC13 H2BC13 LOC108513437 LOC108513437 H2BC1 H2BC1 HERC2 HERC2 BRIP1 BRIP1 LOC108513411-2 LOC108513411-2 LOC108520651 LOC108520651 LOC108525434 LOC108525434 ENSRBIP00000006844 ENSRBIP00000006844 RMI1 RMI1 RNF4 RNF4 LOC108513393 LOC108513393 LOC108526191 LOC108526191 UBA52 UBA52 LOC108513260 LOC108513260 RCBTB2 RCBTB2 LOC108544889 LOC108544889 LOC108538182 LOC108538182 HUS1B HUS1B H2BC5 H2BC5 LOC108536802 LOC108536802 LOC108513418 LOC108513418 H3-4 H3-4 SIRT6 SIRT6 LOC108513411-3 LOC108513411-3 BLM BLM ENSRBIP00000011806 ENSRBIP00000011806 H2BC3 H2BC3 H2BC11 H2BC11 RHNO1 RHNO1 CLSPN CLSPN ENSRBIP00000013673 ENSRBIP00000013673 ENSRBIP00000013688 ENSRBIP00000013688 TOP3A TOP3A ENSRBIP00000014751 ENSRBIP00000014751 WRN WRN MDC1 MDC1 TP53BP1 TP53BP1 RAD9A RAD9A ENSRBIP00000017948 ENSRBIP00000017948 BABAM2 BABAM2 ENSRBIP00000018131 ENSRBIP00000018131 SUMO3 SUMO3 RECQL4 RECQL4 RAD50 RAD50 ENSRBIP00000019157 ENSRBIP00000019157 SUMO2 SUMO2 ENSRBIP00000019958 ENSRBIP00000019958 RCBTB1 RCBTB1 ATM ATM RFC2 RFC2 ENSRBIP00000020891 ENSRBIP00000020891 MRE11 MRE11 UBE2V2 UBE2V2 TIPIN TIPIN RAD9B RAD9B ENSRBIP00000023642 ENSRBIP00000023642 RNF169 RNF169 CCNA1 CCNA1 RAD1 RAD1 RPA1 RPA1 EXO1 EXO1 NBN NBN ATR ATR RFC4 RFC4 ABRAXAS1 ABRAXAS1 HUS1 HUS1 RMI2 RMI2 KAT5 KAT5 RFC5 RFC5 ENSRBIP00000029173 ENSRBIP00000029173 RNF168 RNF168 CDK3 CDK3 UIMC1 UIMC1 RPA3 RPA3 ENSRBIP00000033406 ENSRBIP00000033406 ENSRBIP00000033764 ENSRBIP00000033764 PPP4R2 PPP4R2 ENSRBIP00000034615 ENSRBIP00000034615 DNA2 DNA2 BRCC3 BRCC3 CCNA2 CCNA2 CDK2 CDK2 PIAS4 PIAS4 ENSRBIP00000037358 ENSRBIP00000037358 TOPBP1 TOPBP1 NSD2 NSD2 RFC3 RFC3 RAD17 RAD17 BARD1 BARD1 H2BC15 H2BC15 BABAM1 BABAM1 BRCA1 BRCA1 ATRIP ATRIP RBBP8 RBBP8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSRBIP00000015800Ubiquitin-like domain-containing protein. (132 aa)
LOC108515700Serine/threonine-protein phosphatase. (281 aa)
CDCA7LCell division cycle associated 7 like. (455 aa)
LOC108512615Histone domain-containing protein; Belongs to the histone H2B family. (168 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
LOC108533652Histone H2B; Belongs to the histone H2B family. (127 aa)
ENSRBIP00000001317Ubiquitin-like domain-containing protein. (155 aa)
H2BC21Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108513434Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108530500Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
TIMELESSTimeless circadian regulator. (1208 aa)
LOC108530500-2Histone H4. (103 aa)
UBE2IUbiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family. (231 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSRBIP00000002862Uncharacterized protein. (276 aa)
LOC108530500-3Histone H4. (103 aa)
ENSRBIP00000003378Metallophos domain-containing protein. (233 aa)
ENSRBIP00000003466Ubiquitin-like domain-containing protein. (128 aa)
ENSRBIP00000003512Small ubiquitin-related modifier. (95 aa)
LOC108525496Histone H4-like. (101 aa)
ENSRBIP00000003802Ubiquitin-like domain-containing protein. (84 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (468 aa)
LOC108520555Histone H4. (103 aa)
LOC108513419Histone H4. (103 aa)
ENSRBIP00000004187Ubiquitin-like domain-containing protein. (153 aa)
ENSRBIP00000004777Rad60-SLD domain-containing protein. (51 aa)
LOC108513411Histone H2B; Belongs to the histone H2B family. (126 aa)
UBE2NLUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
LOC108540122Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC13Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108513437Histone H4. (103 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
HERC2HECT domain-containing protein. (507 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1226 aa)
LOC108513411-2Histone H2B type 1. (126 aa)
LOC108520651UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LOC108525434Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSRBIP00000006844Uncharacterized protein. (72 aa)
RMI1RecQ mediated genome instability 1. (625 aa)
RNF4Ring finger protein 4. (190 aa)
LOC108513393Histone H2B type 1. (126 aa)
LOC108526191UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (112 aa)
UBA52Ubiquitin-like domain-containing protein. (232 aa)
LOC108513260SER_THR_PHOSPHATASE domain-containing protein. (120 aa)
RCBTB2RCC1 and BTB domain containing protein 2. (556 aa)
LOC108544889Histone domain-containing protein; Belongs to the histone H2B family. (168 aa)
LOC108538182MPN domain-containing protein. (237 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (277 aa)
H2BC5Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108536802Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC108513418Histone H4. (103 aa)
H3-4Histone H3; Belongs to the histone H3 family. (136 aa)
SIRT6Sirtuin 6. (355 aa)
LOC108513411-3Histone H2B type 1. (126 aa)
BLMBLM RecQ like helicase. (1396 aa)
ENSRBIP00000011806UBIQUITIN_CONJUGAT_2 domain-containing protein. (145 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
H2BC11Histone H2B; Belongs to the histone H2B family. (126 aa)
RHNO1Uncharacterized protein. (240 aa)
CLSPNClaspin. (1301 aa)
ENSRBIP00000013673Ubiquitin-like domain-containing protein. (132 aa)
ENSRBIP00000013688Uncharacterized protein. (232 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
ENSRBIP00000014751UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (105 aa)
WRNWRN RecQ like helicase. (1394 aa)
MDC1Mediator of DNA damage checkpoint 1. (2087 aa)
TP53BP1Tumor protein p53 binding protein 1. (1943 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa)
ENSRBIP00000017948Ubiquitin-like domain-containing protein. (119 aa)
BABAM2BRISC and BRCA1 A complex member 2. (415 aa)
ENSRBIP00000018131Histone H2B; Belongs to the histone H2B family. (129 aa)
SUMO3Small ubiquitin-related modifier. (97 aa)
RECQL4RecQ like helicase 4. (1197 aa)
RAD50Zinc-hook domain-containing protein. (1281 aa)
ENSRBIP00000019157UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (78 aa)
SUMO2Ubiquitin-like domain-containing protein. (80 aa)
ENSRBIP00000019958Uncharacterized protein. (231 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa)
RFC2Replication factor C subunit 2. (352 aa)
ENSRBIP00000020891Uncharacterized protein. (64 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (144 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (288 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (404 aa)
ENSRBIP00000023642Uncharacterized protein. (72 aa)
RNF169Ring finger protein 169. (659 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
RAD1Uncharacterized protein. (280 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
EXO1Exonuclease 1. (827 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa)
RFC4Replication factor C subunit 4. (362 aa)
ABRAXAS1Abraxas 1, BRCA1 A complex subunit. (408 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
RMI2RecQ mediated genome instability 2. (150 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
RFC5Replication factor C subunit 5. (309 aa)
ENSRBIP00000029173Ubiquitin-like domain-containing protein. (166 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
UIMC1Ubiquitin interaction motif containing 1. (719 aa)
RPA3Replication protein A3. (121 aa)
ENSRBIP00000033406UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
ENSRBIP00000033764Histone H2B; Belongs to the histone H2B family. (134 aa)
PPP4R2Uncharacterized protein. (417 aa)
ENSRBIP00000034615TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (275 aa)
DNA2DNA replication helicase/nuclease 2. (1047 aa)
BRCC3MPN domain-containing protein. (297 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa)
PIAS4Protein inhibitor of activated STAT 4. (508 aa)
ENSRBIP00000037358DUF1725 domain-containing protein. (64 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1527 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1368 aa)
RFC3Replication factor C subunit 3. (356 aa)
RAD17RAD17 checkpoint clamp loader component. (676 aa)
BARD1BRCA1 associated RING domain 1. (771 aa)
H2BC15Histone H2B; Belongs to the histone H2B family. (166 aa)
BABAM1BRISC and BRCA1 A complex member 1. (329 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1818 aa)
ATRIPATR interacting protein. (790 aa)
RBBP8RB binding protein 8, endonuclease. (898 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.