STRINGSTRING
AURKC AURKC WRN WRN TAF7L TAF7L RAD9A RAD9A ENSRBIP00000018144 ENSRBIP00000018144 ENSRBIP00000018276 ENSRBIP00000018276 RECQL4 RECQL4 RAD50 RAD50 ENSRBIP00000019958 ENSRBIP00000019958 SSRP1 SSRP1 ENSRBIP00000020228 ENSRBIP00000020228 PRKAB1 PRKAB1 ATM ATM RFC2 RFC2 ENSRBIP00000021229 ENSRBIP00000021229 MRE11 MRE11 TP53RK TP53RK TAF6 TAF6 RAD9B RAD9B CCNA1 CCNA1 RAD1 RAD1 CDK5 CDK5 ENSRBIP00000025123 ENSRBIP00000025123 LOC108524569 LOC108524569 CSNK2A1 CSNK2A1 RPA1 RPA1 EXO1 EXO1 PRKAA1 PRKAA1 NBN NBN TP53INP1 TP53INP1 CSNK2B CSNK2B ATR ATR RFC4 RFC4 HUS1 HUS1 NOC2L NOC2L RMI2 RMI2 MAPK14 MAPK14 SUPT16H SUPT16H TP53 TP53 KAT5 KAT5 RFC5 RFC5 ENSRBIP00000029173 ENSRBIP00000029173 MDM4 MDM4 AURKB AURKB TAF4 TAF4 LOC108514681 LOC108514681 TAF9B TAF9B TAF1 TAF1 CDK3 CDK3 TAF2 TAF2 HIPK2 HIPK2 RPA3 RPA3 ENSRBIP00000033808 ENSRBIP00000033808 MAPKAPK5 MAPKAPK5 MAPK11 MAPK11 DNA2 DNA2 PLK3 PLK3 TAF10 TAF10 CCNA2 CCNA2 NUAK1 NUAK1 CDK2 CDK2 AURKA AURKA LOC108522544 LOC108522544 LOC108518623 LOC108518623 PRKAA2 PRKAA2 TOPBP1 TOPBP1 TAF15 TAF15 TAF5 TAF5 RFC3 RFC3 RAD17 RAD17 BARD1 BARD1 BRCA1 BRCA1 ATRIP ATRIP SLF1 SLF1 TAF11 TAF11 RBBP8 RBBP8 ENSRBIP00000004747 ENSRBIP00000004747 LOC108540530 LOC108540530 LOC108529634 LOC108529634 BRIP1 BRIP1 PRKAG2 PRKAG2 ENSRBIP00000006659 ENSRBIP00000006659 PIN1 PIN1 STK11 STK11 RMI1 RMI1 UBA52 UBA52 HIPK1 HIPK1 MDM2 MDM2 TPX2 TPX2 TBP TBP ENSRBIP00000004187 ENSRBIP00000004187 ENSRBIP00000003802 ENSRBIP00000003802 TAF3 TAF3 ENSRBIP00000003378 ENSRBIP00000003378 HIPK4 HIPK4 NUAK2 NUAK2 PRKAG3 PRKAG3 ENSRBIP00000001317 ENSRBIP00000001317 TAF12 TAF12 TP53INP2 TP53INP2 RPS27A RPS27A CDCA7L CDCA7L PRKAG1 PRKAG1 HIPK3 HIPK3 HUS1B HUS1B PRKAB2 PRKAB2 TAF4B TAF4B BLM BLM CDK5R1 CDK5R1 ENSRBIP00000012047 ENSRBIP00000012047 DYRK3 DYRK3 CSNK2A2 CSNK2A2 MEIOB MEIOB ENSRBIP00000012514 ENSRBIP00000012514 RHNO1 RHNO1 ENSRBIP00000013688 ENSRBIP00000013688 TBPL1 TBPL1 EXD2 EXD2 TOP3A TOP3A TDRD3 TDRD3 CHEK2 CHEK2 DYRK2 DYRK2 DYRK4 DYRK4 ENSRBIP00000015197 ENSRBIP00000015197
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AURKCAurora kinase C; Belongs to the protein kinase superfamily. (195 aa)
WRNWRN RecQ like helicase. (1394 aa)
TAF7LTATA-box binding protein associated factor 7 like. (464 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (390 aa)
ENSRBIP00000018144Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (366 aa)
ENSRBIP00000018276Uncharacterized protein. (194 aa)
RECQL4RecQ like helicase 4. (1197 aa)
RAD50Zinc-hook domain-containing protein. (1281 aa)
ENSRBIP00000019958Uncharacterized protein. (231 aa)
SSRP1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa)
ENSRBIP00000020228Uncharacterized protein. (132 aa)
PRKAB1Protein kinase AMP-activated non-catalytic subunit beta 1. (270 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa)
RFC2Replication factor C subunit 2. (352 aa)
ENSRBIP00000021229Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (374 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (667 aa)
TP53RKTP53 regulating kinase. (253 aa)
TAF6TATA-box binding protein associated factor 6. (737 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (404 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
RAD1Uncharacterized protein. (280 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ENSRBIP00000025123Protein kinase domain-containing protein. (348 aa)
LOC108524569Ubiquitin-like domain-containing protein. (141 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (340 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
EXO1Exonuclease 1. (827 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (241 aa)
CSNK2BUncharacterized protein. (298 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa)
RFC4Replication factor C subunit 4. (362 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (762 aa)
RMI2RecQ mediated genome instability 2. (150 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit. (1047 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (513 aa)
RFC5Replication factor C subunit 5. (309 aa)
ENSRBIP00000029173Ubiquitin-like domain-containing protein. (166 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
TAF4TATA-box binding protein associated factor 4. (1026 aa)
LOC108514681Uncharacterized protein. (252 aa)
TAF9BTATA-box binding protein associated factor 9b. (251 aa)
TAF1TATA-box binding protein associated factor 1. (1713 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
TAF2TATA-box binding protein associated factor 2. (863 aa)
HIPK2Homeodomain interacting protein kinase 2. (1209 aa)
RPA3Replication protein A3. (121 aa)
ENSRBIP00000033808Uncharacterized protein. (73 aa)
MAPKAPK5MAPK activated protein kinase 5. (471 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
DNA2DNA replication helicase/nuclease 2. (1047 aa)
PLK3Serine/threonine-protein kinase PLK. (647 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (229 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
NUAK1NUAK family kinase 1. (654 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa)
AURKAProtein kinase domain-containing protein. (393 aa)
LOC108522544Protein kinase domain-containing protein. (175 aa)
LOC108518623TAFII28 domain-containing protein. (193 aa)
PRKAA2Non-specific serine/threonine protein kinase. (539 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1527 aa)
TAF15TATA-box binding protein associated factor 15. (592 aa)
TAF5TATA-box binding protein associated factor 5. (610 aa)
RFC3Replication factor C subunit 3. (356 aa)
RAD17RAD17 checkpoint clamp loader component. (676 aa)
BARD1BRCA1 associated RING domain 1. (771 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1818 aa)
ATRIPATR interacting protein. (790 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1050 aa)
TAF11TATA-box binding protein associated factor 11. (211 aa)
RBBP8RB binding protein 8, endonuclease. (898 aa)
ENSRBIP00000004747Ubiquitin-like domain-containing protein. (128 aa)
LOC108540530Ubiquitin A-52 residue ribosomal protein fusion product 1. (77 aa)
LOC108529634Ubiquitin-like domain-containing protein. (128 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1226 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (371 aa)
ENSRBIP00000006659Protein kinase domain-containing protein. (275 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (433 aa)
RMI1RecQ mediated genome instability 1. (625 aa)
UBA52Ubiquitin-like domain-containing protein. (232 aa)
HIPK1Homeodomain interacting protein kinase 1. (1417 aa)
MDM2MDM2 proto-oncogene. (513 aa)
TPX2TPX2 microtubule nucleation factor. (697 aa)
TBPTATA-box binding protein. (338 aa)
ENSRBIP00000004187Ubiquitin-like domain-containing protein. (153 aa)
ENSRBIP00000003802Ubiquitin-like domain-containing protein. (84 aa)
TAF3TATA-box binding protein associated factor 3. (838 aa)
ENSRBIP00000003378Metallophos domain-containing protein. (233 aa)
HIPK4Homeodomain interacting protein kinase 4. (615 aa)
NUAK2NUAK family kinase 2. (672 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (489 aa)
ENSRBIP00000001317Ubiquitin-like domain-containing protein. (155 aa)
TAF12TATA-box binding protein associated factor 12. (213 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (220 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
CDCA7LCell division cycle associated 7 like. (455 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (331 aa)
HIPK3Homeodomain interacting protein kinase 3. (1215 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (277 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
TAF4BTATA-box binding protein associated factor 4b. (862 aa)
BLMBLM RecQ like helicase. (1396 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
ENSRBIP00000012047Peptidyl-prolyl cis-trans isomerase. (154 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (588 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
MEIOBMeiosis specific with OB-fold. (449 aa)
ENSRBIP00000012514Ubiquitin-like domain-containing protein. (121 aa)
RHNO1Uncharacterized protein. (240 aa)
ENSRBIP00000013688Uncharacterized protein. (232 aa)
TBPL1TATA-box binding protein like 1. (186 aa)
EXD2Exonuclease 3'-5' domain containing 2. (621 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
TDRD3Tudor domain containing 3. (749 aa)
CHEK2Checkpoint kinase 2. (589 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (595 aa)
DYRK4Dual specificity tyrosine phosphorylation regulated kinase 4. (636 aa)
ENSRBIP00000015197Uncharacterized protein. (114 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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