STRINGSTRING
ENSRBIP00000012514 ENSRBIP00000012514 DAXX DAXX CHEK2 CHEK2 PDPK1 PDPK1 ENSRBIP00000015197 ENSRBIP00000015197 RFFL RFFL PPP2CB PPP2CB ENSRBIP00000020228 ENSRBIP00000020228 ATM ATM CDK1 CDK1 ENSRBIP00000020927 ENSRBIP00000020927 ENSRBIP00000021908 ENSRBIP00000021908 CCNA1 CCNA1 USP2 USP2 LOC108524569 LOC108524569 USP7 USP7 TP53 TP53 ENSRBIP00000029173 ENSRBIP00000029173 MDM4 MDM4 RICTOR RICTOR CDK3 CDK3 SGK1 SGK1 TXNDC11 TXNDC11 AKT2 AKT2 AKT3 AKT3 CCNA2 CCNA2 CDK2 CDK2 PPP2CA PPP2CA PRR5 PRR5 ENSRBIP00000039712 ENSRBIP00000039712 MAPKAP1 MAPKAP1 PPP2R5C PPP2R5C PHF20 PHF20 RPS27A RPS27A ENSRBIP00000001317 ENSRBIP00000001317 MLST8 MLST8 ENSRBIP00000003802 ENSRBIP00000003802 RNF34 RNF34 ENSRBIP00000004187 ENSRBIP00000004187 MTOR MTOR ENSRBIP00000004747 ENSRBIP00000004747 LOC108540530 LOC108540530 LOC108529634 LOC108529634 ENSRBIP00000007312 ENSRBIP00000007312 PPP2R1B PPP2R1B UBA52 UBA52 MDM2 MDM2 CCNG1 CCNG1 PRDM1 PRDM1 PPP2R1A PPP2R1A AKT1 AKT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSRBIP00000012514Ubiquitin-like domain-containing protein. (121 aa)
DAXXDeath domain associated protein. (740 aa)
CHEK2Checkpoint kinase 2. (589 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (351 aa)
ENSRBIP00000015197Uncharacterized protein. (114 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (363 aa)
PPP2CBSerine/threonine-protein phosphatase. (304 aa)
ENSRBIP00000020228Uncharacterized protein. (132 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
ENSRBIP00000020927Uncharacterized protein. (147 aa)
ENSRBIP00000021908Uncharacterized protein. (91 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (465 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (605 aa)
LOC108524569Ubiquitin-like domain-containing protein. (141 aa)
USP7Uncharacterized protein; Belongs to the peptidase C19 family. (1105 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
ENSRBIP00000029173Ubiquitin-like domain-containing protein. (166 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (490 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1729 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
TXNDC11Thioredoxin domain containing 11. (980 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (432 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PRR5Proline rich 5. (410 aa)
ENSRBIP00000039712Uncharacterized protein. (320 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (571 aa)
PHF20PHD finger protein 20. (1011 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
ENSRBIP00000001317Ubiquitin-like domain-containing protein. (155 aa)
MLST8MTOR associated protein, LST8 homolog. (335 aa)
ENSRBIP00000003802Ubiquitin-like domain-containing protein. (84 aa)
RNF34Ring finger protein 34. (376 aa)
ENSRBIP00000004187Ubiquitin-like domain-containing protein. (153 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
ENSRBIP00000004747Ubiquitin-like domain-containing protein. (128 aa)
LOC108540530Ubiquitin A-52 residue ribosomal protein fusion product 1. (77 aa)
LOC108529634Ubiquitin-like domain-containing protein. (128 aa)
ENSRBIP00000007312Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (454 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
UBA52Ubiquitin-like domain-containing protein. (232 aa)
MDM2MDM2 proto-oncogene. (513 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
PRDM1PR/SET domain 1. (825 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
AKT1AKT serine/threonine kinase 1. (486 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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