STRINGSTRING
MET MET SH3GL2 SH3GL2 CBL CBL HGS HGS EPS15 EPS15 ENSRBIP00000004187 ENSRBIP00000004187 ENSRBIP00000003802 ENSRBIP00000003802 ENSRBIP00000001317 ENSRBIP00000001317 RPS27A RPS27A SH3KBP1 SH3KBP1 GRB2 GRB2 ENSRBIP00000029173 ENSRBIP00000029173 STAM2 STAM2 SH3GL1 SH3GL1 SH3GL3 SH3GL3 STAM STAM UBA52 UBA52
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
METMET proto-oncogene, receptor tyrosine kinase. (1383 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (315 aa)
CBLCbl proto-oncogene. (802 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (899 aa)
ENSRBIP00000004187Ubiquitin-like domain-containing protein. (153 aa)
ENSRBIP00000003802Ubiquitin-like domain-containing protein. (84 aa)
ENSRBIP00000001317Ubiquitin-like domain-containing protein. (155 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (372 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ENSRBIP00000029173Ubiquitin-like domain-containing protein. (166 aa)
STAM2Signal transducing adaptor molecule 2. (519 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (368 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (286 aa)
STAMSignal transducing adaptor molecule. (540 aa)
UBA52Ubiquitin-like domain-containing protein. (232 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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