STRINGSTRING
MECP2 MECP2 TNRC6A TNRC6A GPS2 GPS2 FOXG1 FOXG1 TBL1XR1 TBL1XR1 TNRC6C TNRC6C CAMK2D CAMK2D TBL1X TBL1X ENSRBIP00000008820 ENSRBIP00000008820 AGO2 AGO2 LOC108532627 LOC108532627 ENSRBIP00000015709 ENSRBIP00000015709 LOC108527145 LOC108527145 AGO1 AGO1 ENSRBIP00000018271 ENSRBIP00000018271 HDAC1 HDAC1 CAMK4 CAMK4 TNRC6B TNRC6B HDAC2 HDAC2 HTT HTT NCOR2 NCOR2 ENSRBIP00000029999 ENSRBIP00000029999 AURKB AURKB AGO4 AGO4 HIPK2 HIPK2 HDAC3 HDAC3 CREB1 CREB1 MOV10 MOV10 CAMK2A CAMK2A SIN3A SIN3A NCOR1 NCOR1 CAMK2G CAMK2G LBR LBR AGO3 AGO3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
TNRC6ATrinucleotide repeat containing adaptor 6A. (1951 aa)
GPS2G protein pathway suppressor 2. (327 aa)
FOXG1Forkhead box G1. (445 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (514 aa)
TNRC6CTrinucleotide repeat containing adaptor 6C. (1935 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
TBL1XTransducin beta like 1 X-linked. (586 aa)
ENSRBIP00000008820Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (470 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (879 aa)
LOC108532627Hist_deacetyl domain-containing protein. (210 aa)
ENSRBIP00000015709Uncharacterized protein. (205 aa)
LOC108527145Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (469 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
ENSRBIP00000018271Hist_deacetyl domain-containing protein. (180 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (472 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1832 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
HTTHuntingtin. (3068 aa)
NCOR2Nuclear receptor corepressor 2. (2488 aa)
ENSRBIP00000029999Protein kinase domain-containing protein. (335 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (848 aa)
HIPK2Homeodomain interacting protein kinase 2. (1209 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
MOV10Mov10 RISC complex RNA helicase. (1003 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
SIN3ASIN3 transcription regulator family member A. (1228 aa)
NCOR1Nuclear receptor corepressor 1. (2441 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (547 aa)
LBRLamin B receptor. (609 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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