40 items (Rhinopithecus bieti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (848 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (883 aa)
	APOC4	Uncharacterized protein. (127 aa)
	ABCG5	ATP binding cassette subfamily G member 5. (651 aa)
	RXRB	Retinoid X receptor beta. (508 aa)
	NCOR2	Nuclear receptor corepressor 2. (2488 aa)
	ABCA1	ATP binding cassette subfamily A member 1. (2261 aa)
	TNRC6B	Trinucleotide repeat containing adaptor 6B. (1832 aa)
	NCOA1	Nuclear receptor coactivator. (1433 aa)
	APOC2	Apolipoprotein C2. (101 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (461 aa)
	APOE	Apolipoprotein E. (317 aa)
	CETP	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
	ARL4C	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (202 aa)
	AGO1	Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
	KDM3A	Lysine demethylase 3A. (1322 aa)
	ENSRBIP00000015709	Uncharacterized protein. (205 aa)
	EEPD1	Endonuclease/exonuclease/phosphatase family domain containing 1. (569 aa)
	LOC108532627	Hist_deacetyl domain-containing protein. (210 aa)
	ENSRBIP00000012572	Uncharacterized protein. (100 aa)
	APOD	Apolipoprotein D. (215 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (879 aa)
	TBL1X	Transducin beta like 1 X-linked. (586 aa)
	TNRC6C	Trinucleotide repeat containing adaptor 6C. (1935 aa)
	ABCG1	ATP binding cassette subfamily G member 1. (676 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (514 aa)
	ABCG8	ATP binding cassette subfamily G member 8. (673 aa)
	GPS2	G protein pathway suppressor 2. (327 aa)
	PLTP	Phospholipid transfer protein. (493 aa)
	TNRC6A	Trinucleotide repeat containing adaptor 6A. (1951 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (441 aa)
	ARL4A	ADP ribosylation factor like GTPase 4A. (200 aa)
	RXRA	Retinoid X receptor alpha. (492 aa)
	ENSRBIP00000040145	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (205 aa)
	AGO3	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
	KDM4A	Uncharacterized protein. (1064 aa)
	MOV10	Mov10 RISC complex RNA helicase. (1003 aa)
	NCOR1	Nuclear receptor corepressor 1. (2441 aa)
	EP300	E1A binding protein p300. (2296 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	APOD	ENSRBIP00000023389	ENSRBIP00000009861	ATP binding cassette subfamily A member 1.	Apolipoprotein D.	0.438
ABCA1	APOE	ENSRBIP00000023389	ENSRBIP00000021650	ATP binding cassette subfamily A member 1.	Apolipoprotein E.	0.652
ABCA1	CETP	ENSRBIP00000023389	ENSRBIP00000018836	ATP binding cassette subfamily A member 1.	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.561
ABCA1	NR1H2	ENSRBIP00000023389	ENSRBIP00000022722	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 2.	0.856
ABCA1	NR1H3	ENSRBIP00000023389	ENSRBIP00000000571	ATP binding cassette subfamily A member 1.	Nuclear receptor subfamily 1 group H member 3.	0.770
ABCA1	PLTP	ENSRBIP00000023389	ENSRBIP00000003224	ATP binding cassette subfamily A member 1.	Phospholipid transfer protein.	0.465
ABCA1	RXRA	ENSRBIP00000023389	ENSRBIP00000038762	ATP binding cassette subfamily A member 1.	Retinoid X receptor alpha.	0.672
ABCG1	ABCG5	ENSRBIP00000006992	ENSRBIP00000031490	ATP binding cassette subfamily G member 1.	ATP binding cassette subfamily G member 5.	0.853
ABCG1	APOE	ENSRBIP00000006992	ENSRBIP00000021650	ATP binding cassette subfamily G member 1.	Apolipoprotein E.	0.577
ABCG1	NR1H2	ENSRBIP00000006992	ENSRBIP00000022722	ATP binding cassette subfamily G member 1.	Nuclear receptor subfamily 1 group H member 2.	0.577
ABCG1	NR1H3	ENSRBIP00000006992	ENSRBIP00000000571	ATP binding cassette subfamily G member 1.	Nuclear receptor subfamily 1 group H member 3.	0.628
ABCG5	ABCG1	ENSRBIP00000031490	ENSRBIP00000006992	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 1.	0.853
ABCG5	ABCG8	ENSRBIP00000031490	ENSRBIP00000005455	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 8.	0.999
ABCG5	NR1H2	ENSRBIP00000031490	ENSRBIP00000022722	ATP binding cassette subfamily G member 5.	Nuclear receptor subfamily 1 group H member 2.	0.550
ABCG5	NR1H3	ENSRBIP00000031490	ENSRBIP00000000571	ATP binding cassette subfamily G member 5.	Nuclear receptor subfamily 1 group H member 3.	0.636
ABCG8	ABCG5	ENSRBIP00000005455	ENSRBIP00000031490	ATP binding cassette subfamily G member 8.	ATP binding cassette subfamily G member 5.	0.999
ABCG8	NR1H2	ENSRBIP00000005455	ENSRBIP00000022722	ATP binding cassette subfamily G member 8.	Nuclear receptor subfamily 1 group H member 2.	0.533
ABCG8	NR1H3	ENSRBIP00000005455	ENSRBIP00000000571	ATP binding cassette subfamily G member 8.	Nuclear receptor subfamily 1 group H member 3.	0.563
ABCG8	PLTP	ENSRBIP00000005455	ENSRBIP00000003224	ATP binding cassette subfamily G member 8.	Phospholipid transfer protein.	0.400
AGO1	AGO2	ENSRBIP00000017207	ENSRBIP00000009252	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.976