STRINGSTRING
HMGB1 HMGB1 MAP2K1 MAP2K1 ENSRBIP00000014751 ENSRBIP00000014751 ENSRBIP00000014363 ENSRBIP00000014363 RPS6KA3 RPS6KA3 LRRC31 LRRC31 S100A12 S100A12 LRRC74A LRRC74A ATF1 ATF1 ENSRBIP00000013354 ENSRBIP00000013354 CUL1 CUL1 IRF3 IRF3 ENSRBIP00000012514 ENSRBIP00000012514 TAB2 TAB2 NFKB1 NFKB1 MAPKAPK3 MAPKAPK3 S100B S100B NLRP13 NLRP13 BIRC2 BIRC2 MEF2A MEF2A NLRP9 NLRP9 ENSRBIP00000010265 ENSRBIP00000010265 LRRC34 LRRC34 PPP2R1A PPP2R1A ENSRBIP00000009767 ENSRBIP00000009767 TRAF5 TRAF5 LRRC14 LRRC14 RPS6KA1 RPS6KA1 NFKB2 NFKB2 VRK3 VRK3 UBA52 UBA52 PPP2R1B PPP2R1B LOC108526191 LOC108526191 NKIRAS1 NKIRAS1 MAPK9 MAPK9 ENSRBIP00000006958 ENSRBIP00000006958 PPP2R5D PPP2R5D KHNYN KHNYN ELK1 ELK1 TLR4 TLR4 LOC108520651 LOC108520651 HMGB1-2 HMGB1-2 TAB1 TAB1 LOC108529634 LOC108529634 LOC108540530 LOC108540530 MAP3K7 MAP3K7 UBE2NL UBE2NL ENSRBIP00000004747 ENSRBIP00000004747 IKBKE IKBKE ENSRBIP00000004187 ENSRBIP00000004187 RPS6KA2 RPS6KA2 RIPK2 RIPK2 ENSRBIP00000003802 ENSRBIP00000003802 BIRC3 BIRC3 LOC108544295 LOC108544295 TONSL TONSL MAPK10 MAPK10 NOD2 NOD2 ENSRBIP00000002911 ENSRBIP00000002911 DUSP7 DUSP7 RIPK3 RIPK3 ENSRBIP00000002079 ENSRBIP00000002079 TIFA TIFA ENSRBIP00000001317 ENSRBIP00000001317 TNIP2 TNIP2 LY96 LY96 RPS27A RPS27A MAPK3 MAPK3 BTRC BTRC TICAM2 TICAM2 FOS FOS TICAM1 TICAM1 LOC108515310 LOC108515310 CHUK CHUK NAIP NAIP AGER AGER ENSRBIP00000023060 ENSRBIP00000023060 ALPK1 ALPK1 CD14 CD14 ENSRBIP00000022247 ENSRBIP00000022247 N4BP1 N4BP1 RELCH RELCH ENSRBIP00000020927 ENSRBIP00000020927 MAP2K6 MAP2K6 LRRC71 LRRC71 RELA RELA NLRP6 NLRP6 MAPK15 MAPK15 ENSRBIP00000019157 ENSRBIP00000019157 NFKBIB NFKBIB ENSRBIP00000020047 ENSRBIP00000020047 MAP2K4 MAP2K4 FBXW11 FBXW11 IRAK2 IRAK2 ENSRBIP00000029173 ENSRBIP00000029173 MAP3K8 MAP3K8 TP53 TP53 MAPK14 MAPK14 IKBKB IKBKB FOSL2 FOSL2 PTPN11 PTPN11 ENSRBIP00000026978 ENSRBIP00000026978 NLRX1 NLRX1 MAPK1 MAPK1 ENSRBIP00000026419 ENSRBIP00000026419 IRAK1 IRAK1 FADD FADD TANK TANK IRF7 IRF7 LOC108524569 LOC108524569 BIRC7 BIRC7 USP14 USP14 PPP2CA PPP2CA CASP8 CASP8 TRAF3 TRAF3 RIPK1 RIPK1 LRRC45 LRRC45 LOC108528435 LOC108528435 ENSRBIP00000039839 ENSRBIP00000039839 FNBP4 FNBP4 CREM CREM NFKBIA NFKBIA MAPK7 MAPK7 ENSRBIP00000038500 ENSRBIP00000038500 PPP4R4 PPP4R4 APP APP SARM1 SARM1 TAB3 TAB3 PPP4R1 PPP4R1 RPS6KA5 RPS6KA5 LOC108524385 LOC108524385 MAP2K7 MAP2K7 SKP1 SKP1 TRAF6 TRAF6 ATF2 ATF2 ENSRBIP00000035735 ENSRBIP00000035735 LOC108528453 LOC108528453 DUSP6 DUSP6 NLRC5 NLRC5 NKIRAS2 NKIRAS2 MAPK11 MAPK11 MAPKAPK2 MAPKAPK2 ENSRBIP00000033992 ENSRBIP00000033992 CREB1 CREB1 VWC2 VWC2 LOC108525504 LOC108525504 CCDC71L CCDC71L MEF2C MEF2C ENSRBIP00000033406 ENSRBIP00000033406 ENSRBIP00000032719 ENSRBIP00000032719 NOD1 NOD1 DUSP4 DUSP4 ENSRBIP00000032381 ENSRBIP00000032381 MAPK8 MAPK8 CREB5 CREB5 TRAF2 TRAF2 TBK1 TBK1 ENSRBIP00000020228 ENSRBIP00000020228 MAP3K20 MAP3K20 MAP2K3 MAP2K3 ENSRBIP00000017090 ENSRBIP00000017090 ATF7 ATF7 ENSRBIP00000016878 ENSRBIP00000016878 PPP2CB PPP2CB ENSRBIP00000016494 ENSRBIP00000016494 DUSP3 DUSP3 ENSRBIP00000015185 ENSRBIP00000015185 IKBKG IKBKG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HMGB1Uncharacterized protein. (181 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ENSRBIP00000014751UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (105 aa)
ENSRBIP00000014363UBIQUITIN_CONJUGAT_2 domain-containing protein. (128 aa)
RPS6KA3Uncharacterized protein. (66 aa)
LRRC31Leucine rich repeat containing 31. (552 aa)
S100A12S100 calcium binding protein A12; Belongs to the S-100 family. (90 aa)
LRRC74ALeucine rich repeat containing 74A. (485 aa)
ATF1Activating transcription factor 1. (269 aa)
ENSRBIP00000013354IRF-3 domain-containing protein. (139 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
IRF3IRF tryptophan pentad repeat domain-containing protein. (426 aa)
ENSRBIP00000012514Ubiquitin-like domain-containing protein. (121 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
NFKB1Nuclear factor kappa B subunit 1. (969 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (434 aa)
S100BS_100 domain-containing protein; Belongs to the S-100 family. (94 aa)
NLRP13NLR family pyrin domain containing 13. (1044 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
MEF2AMyocyte enhancer factor 2A. (511 aa)
NLRP9NLR family pyrin domain containing 9. (933 aa)
ENSRBIP00000010265Uncharacterized protein. (161 aa)
LRRC34Leucine rich repeat containing 34. (457 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (589 aa)
ENSRBIP00000009767Uncharacterized protein. (546 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (563 aa)
LRRC14Leucine rich repeat containing 14. (493 aa)
RPS6KA1Ribosomal protein S6 kinase. (744 aa)
NFKB2Nuclear factor kappa B subunit 2. (906 aa)
VRK3VRK serine/threonine kinase 3. (479 aa)
UBA52Ubiquitin-like domain-containing protein. (232 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (667 aa)
LOC108526191UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (112 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
ENSRBIP00000006958TNF receptor-associated factor. (473 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (605 aa)
KHNYNKH and NYN domain containing. (678 aa)
ELK1ETS domain-containing protein. (428 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
LOC108520651UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
HMGB1-2Uncharacterized protein. (215 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (512 aa)
LOC108529634Ubiquitin-like domain-containing protein. (128 aa)
LOC108540530Ubiquitin A-52 residue ribosomal protein fusion product 1. (77 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
UBE2NLUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
ENSRBIP00000004747Ubiquitin-like domain-containing protein. (128 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (716 aa)
ENSRBIP00000004187Ubiquitin-like domain-containing protein. (153 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (443 aa)
ENSRBIP00000003802Ubiquitin-like domain-containing protein. (84 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
LOC108544295Uncharacterized protein; Belongs to the SKP1 family. (163 aa)
TONSLTonsoku like, DNA repair protein. (1367 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1153 aa)
ENSRBIP00000002911Uncharacterized protein. (190 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (518 aa)
ENSRBIP00000002079Uncharacterized protein. (202 aa)
TIFATRAF interacting protein with forkhead associated domain. (185 aa)
ENSRBIP00000001317Ubiquitin-like domain-containing protein. (155 aa)
TNIP2CCHC NOA-type domain-containing protein. (337 aa)
LY96Lymphocyte antigen 96. (160 aa)
RPS27AUbiquitin-like domain-containing protein. (156 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
TICAM2Toll like receptor adaptor molecule 2. (235 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
TICAM1Toll like receptor adaptor molecule 1. (515 aa)
LOC108515310WRNPLPNID domain-containing protein. (954 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
NAIPNLR family apoptosis inhibitory protein. (1395 aa)
AGERUncharacterized protein. (417 aa)
ENSRBIP00000023060Protein kinase domain-containing protein. (120 aa)
ALPK1Alpha kinase 1. (1245 aa)
CD14CD14 molecule. (384 aa)
ENSRBIP00000022247Uncharacterized protein. (70 aa)
N4BP1NEDD4 binding protein 1. (895 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1216 aa)
ENSRBIP00000020927Uncharacterized protein. (147 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LRRC71Leucine rich repeat containing 71. (559 aa)
RELAUncharacterized protein. (282 aa)
NLRP6NLR family pyrin domain containing 6. (1041 aa)
MAPK15Mitogen-activated protein kinase. (544 aa)
ENSRBIP00000019157UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (78 aa)
NFKBIBNFKB inhibitor beta. (338 aa)
ENSRBIP00000020047Uncharacterized protein; Belongs to the SKP1 family. (162 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (408 aa)
FBXW11F-box and WD repeat domain containing 11. (522 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (537 aa)
ENSRBIP00000029173Ubiquitin-like domain-containing protein. (166 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (466 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
FOSL2FOS like 2, AP-1 transcription factor subunit. (326 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
ENSRBIP00000026978Uncharacterized protein. (179 aa)
NLRX1NLR family member X1. (972 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
ENSRBIP00000026419Uncharacterized protein. (249 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (702 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
TANKTRAF family member associated NFKB activator. (425 aa)
IRF7Interferon regulatory factor 7. (503 aa)
LOC108524569Ubiquitin-like domain-containing protein. (141 aa)
BIRC7Baculoviral IAP repeat containing 7. (298 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (493 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
TRAF3TNF receptor-associated factor. (477 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (672 aa)
LRRC45Leucine rich repeat containing 45. (669 aa)
LOC108528435Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (130 aa)
ENSRBIP00000039839Uncharacterized protein; Belongs to the SKP1 family. (129 aa)
FNBP4Formin binding protein 4. (925 aa)
CREMcAMP responsive element modulator. (330 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (814 aa)
ENSRBIP00000038500RHD domain-containing protein. (112 aa)
PPP4R4Protein phosphatase 4 regulatory subunit 4. (807 aa)
APPAmyloid beta precursor protein. (770 aa)
SARM1Sterile alpha and TIR motif containing 1. (724 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (690 aa)
PPP4R1Protein phosphatase 4 regulatory subunit 1. (930 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (684 aa)
LOC108524385Uncharacterized protein. (348 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (414 aa)
SKP1Uncharacterized protein; Belongs to the SKP1 family. (154 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (429 aa)
ENSRBIP00000035735Uncharacterized protein. (100 aa)
LOC108528453Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
NLRC5NLR family CARD domain containing 5. (1866 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (231 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
MAPKAPK2MAPK activated protein kinase 2. (392 aa)
ENSRBIP00000033992Uncharacterized protein. (157 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
LOC108525504Uncharacterized protein. (70 aa)
CCDC71LCoiled-coil domain containing 71 like. (235 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ENSRBIP00000033406UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
ENSRBIP00000032719SH2 domain-containing protein. (203 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (953 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
ENSRBIP00000032381Uncharacterized protein. (130 aa)
MAPK8Mitogen-activated protein kinase 8. (383 aa)
CREB5Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription. (503 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (501 aa)
TBK1TANK binding kinase 1. (681 aa)
ENSRBIP00000020228Uncharacterized protein. (132 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (800 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (394 aa)
ENSRBIP00000017090Uncharacterized protein. (120 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (494 aa)
ENSRBIP00000016878Uncharacterized protein. (251 aa)
PPP2CBSerine/threonine-protein phosphatase. (304 aa)
ENSRBIP00000016494Protein kinase domain-containing protein. (253 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (185 aa)
ENSRBIP00000015185ETS domain-containing protein. (421 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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