111 items (Rhinopithecus bieti) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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	PDE1B	Phosphodiesterase. (536 aa)
	ENTPD4	Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (616 aa)
	PNP	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa)
	DCK	Deoxycytidine kinase. (317 aa)
	ENSRBIP00000002156	Uncharacterized protein. (366 aa)
	PDE2A	Phosphodiesterase. (944 aa)
	ENTPD1	Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (522 aa)
	AMPD3	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (776 aa)
	GMPS	Guanine monophosphate synthase. (693 aa)
	PAICS	AIRC domain-containing protein. (450 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
	PDE10A	Phosphodiesterase. (789 aa)
	PDE6H	Phosphodiesterase 6H. (83 aa)
	PDE8B	Phosphodiesterase. (885 aa)
	FHIT	Bis(5'-adenosyl)-triphosphatase. (149 aa)
	NPR2	Guanylate cyclase. (1047 aa)
	ENTPD3	Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (529 aa)
	PDE9A	Phosphodiesterase. (570 aa)
	AMPD2	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (880 aa)
	LOC108534220	Phosphodiesterase. (693 aa)
	PDE1C	Phosphodiesterase. (768 aa)
	GUCY2C	Guanylate cyclase. (1073 aa)
	ENTPD8	Ectonucleoside triphosphate diphosphohydrolase 8; Belongs to the GDA1/CD39 NTPase family. (499 aa)
	NT5C1A	5'-nucleotidase, cytosolic IA. (368 aa)
	ADSS2	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (458 aa)
	ENPP3	Ectonucleotide pyrophosphatase/phosphodiesterase 3. (886 aa)
	LOC108531926	Nucleoside diphosphate kinase. (152 aa)
	URAD	OHCU_decarbox domain-containing protein. (173 aa)
	GMPR2	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (348 aa)
	IMPDH1	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (627 aa)
	AK3	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa)
	AK8	Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa)
	ADA	A_deaminase domain-containing protein. (443 aa)
	NME3	Nucleoside diphosphate kinase. (169 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
	ALLC	Allantoicase. (220 aa)
	GMPR	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
	RRM2B	Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (365 aa)
	NUDT2	Nudix hydrolase 2. (147 aa)
	NUDT9	Nudix hydrolase 9. (350 aa)
	ENTPD2	Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (495 aa)
	ENTPD5	Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family. (428 aa)
	PDE6G	Phosphodiesterase 6G. (136 aa)
	CANT1	Calcium activated nucleotidase 1. (401 aa)
	PAPSS1	3'-phosphoadenosine 5'-phosphosulfate synthase 1. (624 aa)
	ADSL	Adenylosuccinate lyase. (378 aa)
	AK5	Adenylate kinase 5; Belongs to the adenylate kinase family. (562 aa)
	PDE6B	Phosphodiesterase. (855 aa)
	ADCY9	Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
	AK6	Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa)
	ADCY10	Adenylate cyclase 10. (1609 aa)
	NT5C1B	Uncharacterized protein. (610 aa)
	NME6	Nucleoside diphosphate kinase. (186 aa)
	APRT	Adenine phosphoribosyltransferase. (180 aa)
	LOC108529493	PfkB domain-containing protein. (190 aa)
	NME7	Nucleoside diphosphate kinase 7; Belongs to the NDK family. (376 aa)
	LOC108529254	Uncharacterized protein. (528 aa)
	AK7	Adenylate kinase 7. (723 aa)
	ADCY8	Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
	LOC108536807	Pribosyltran_N domain-containing protein. (341 aa)
	AK4	Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
	PDE4A	Phosphodiesterase. (928 aa)
	LOC108522596	Nucleoside diphosphate kinase. (281 aa)
	IMPDH2	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
	NUDT16	Nudix hydrolase 16. (212 aa)
	ENPP4	Ectonucleotide pyrophosphatase/phosphodiesterase 4. (452 aa)
	GUCY1A1	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
	NT5E	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
	ENTPD6	Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (484 aa)
	PFAS	Phosphoribosylformylglycinamidine synthase. (1326 aa)
	ADSS1	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (499 aa)
	RRM1	Ribonucleotide reductase catalytic subunit M1. (570 aa)
	PKLR	Pyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
	GUCY2D	Guanylate cyclase. (1069 aa)
	NME4	Nucleoside diphosphate kinase. (195 aa)
	XDH	Xanthine dehydrogenase. (1333 aa)
	PDE6A	Phosphodiesterase. (860 aa)
	PDE1A	Phosphodiesterase. (501 aa)
	PDE5A	Phosphodiesterase. (876 aa)
	PDE7A	Phosphodiesterase. (482 aa)
	ENSRBIP00000032173	Guanylate cyclase domain-containing protein. (150 aa)
	LOC108529057	5-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (118 aa)
	PPAT	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (517 aa)
	NPR1	Guanylate cyclase. (1061 aa)
	ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (591 aa)
	ADCY5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
	PRUNE1	Prune exopolyphosphatase 1. (453 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
	PRPS1	Pribosyltran_N domain-containing protein. (256 aa)
	NT5C3B	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa)
	DGUOK	Deoxyguanosine kinase. (335 aa)
	PAPSS2	3'-phosphoadenosine 5'-phosphosulfate synthase 2. (640 aa)
	AK1	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (210 aa)
	GUCY2F	Guanylate cyclase 2F, retinal. (597 aa)
	ADPRM	ADP-ribose/CDP-alcohol diphosphatase, manganese dependent. (342 aa)
	PDE4B	Phosphodiesterase. (736 aa)
	PGM2	Phosphoglucomutase 2. (622 aa)
	NT5C	5', 3'-nucleotidase, cytosolic. (201 aa)
	PDE11A	Phosphodiesterase. (933 aa)
	PDE8A	Phosphodiesterase. (827 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (921 aa)
	PDE4D	Phosphodiesterase. (809 aa)
	NT5C2	5'-nucleotidase, cytosolic II. (567 aa)
	PKM	Pyruvate kinase; Belongs to the pyruvate kinase family. (556 aa)
	NT5C3A	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (336 aa)
	PDE6C	Phosphodiesterase. (864 aa)
	GART	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
	PDE7B	Phosphodiesterase. (505 aa)
	HDDC3	HD domain containing 3. (179 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	AMPD2	ENSRBIP00000014982	ENSRBIP00000009643	A_deaminase domain-containing protein.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.443
ADA	AMPD3	ENSRBIP00000014982	ENSRBIP00000002876	A_deaminase domain-containing protein.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.461
ADA	APRT	ENSRBIP00000014982	ENSRBIP00000022418	A_deaminase domain-containing protein.	Adenine phosphoribosyltransferase.	0.860
ADA	DCK	ENSRBIP00000014982	ENSRBIP00000001939	A_deaminase domain-containing protein.	Deoxycytidine kinase.	0.915
ADA	GART	ENSRBIP00000014982	ENSRBIP00000041728	A_deaminase domain-containing protein.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.728
ADA	GMPS	ENSRBIP00000014982	ENSRBIP00000004408	A_deaminase domain-containing protein.	Guanine monophosphate synthase.	0.613
ADA	LOC108529493	ENSRBIP00000014982	ENSRBIP00000022465	A_deaminase domain-containing protein.	PfkB domain-containing protein.	0.958
ADA	NT5C	ENSRBIP00000014982	ENSRBIP00000040148	A_deaminase domain-containing protein.	5', 3'-nucleotidase, cytosolic.	0.937
ADA	NT5C1A	ENSRBIP00000014982	ENSRBIP00000011566	A_deaminase domain-containing protein.	5'-nucleotidase, cytosolic IA.	0.900
ADA	NT5C1B	ENSRBIP00000014982	ENSRBIP00000022161	A_deaminase domain-containing protein.	Uncharacterized protein.	0.900
ADA	NT5C2	ENSRBIP00000014982	ENSRBIP00000041340	A_deaminase domain-containing protein.	5'-nucleotidase, cytosolic II.	0.915
ADA	NT5C3A	ENSRBIP00000014982	ENSRBIP00000041548	A_deaminase domain-containing protein.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.908
ADA	NT5C3B	ENSRBIP00000014982	ENSRBIP00000037123	A_deaminase domain-containing protein.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.908
ADA	NT5E	ENSRBIP00000014982	ENSRBIP00000027221	A_deaminase domain-containing protein.	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family.	0.965
ADA	PNP	ENSRBIP00000014982	ENSRBIP00000001372	A_deaminase domain-containing protein.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.969
ADCY1	ADCY2	ENSRBIP00000035296	ENSRBIP00000024365	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.458
ADCY1	ADCY3	ENSRBIP00000035296	ENSRBIP00000021747	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.944
ADCY1	ADCY5	ENSRBIP00000035296	ENSRBIP00000034265	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.429
ADCY1	ADCY6	ENSRBIP00000035296	ENSRBIP00000004607	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.429
ADCY1	ADCY7	ENSRBIP00000035296	ENSRBIP00000016019	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.488