STRINGSTRING
MAPK3 MAPK3 CDKN1B CDKN1B PIK3R1 PIK3R1 ESR1 ESR1 SRC SRC PIK3R3 PIK3R3 MAPK10 MAPK10 ADCY6 ADCY6 MTOR MTOR MMP9 MMP9 DLL1 DLL1 JAG2 JAG2 DLL3 DLL3 MAPK9 MAPK9 IGF1 IGF1 ARAF ARAF SHC2 SHC2 BCL2 BCL2 CARM1 CARM1 RAF1 RAF1 NOTCH4 NOTCH4 JAG1 JAG1 NCOA3 NCOA3 SHC4 SHC4 GPER1 GPER1 MAP2K1 MAP2K1 MED1 MED1 ADCY7 ADCY7 GRB2 GRB2 PIK3CA PIK3CA CDK4 CDK4 RB1 RB1 MMP2 MMP2 ADCY9 ADCY9 BRAF BRAF ADCY3 ADCY3 HRAS HRAS ADCY8 ADCY8 ADCY2 ADCY2 FOS FOS CCND1 CCND1 CDKN2C CDKN2C MAPK1 MAPK1 KRAS KRAS ESR2 ESR2 MAPK14 MAPK14 TP53 TP53 HBEGF HBEGF ERBB2 ERBB2 E2F2 E2F2 MAPK13 MAPK13 ABCB11 ABCB11 BIK BIK SOS1 SOS1 AKT2 AKT2 ADCY5 ADCY5 AKT3 AKT3 MAPK11 MAPK11 PRKACB PRKACB NCOR1 NCOR1 PIK3CD PIK3CD ADCY1 ADCY1 BAX BAX NOTCH2 NOTCH2 SOS2 SOS2 GNAS GNAS EGFR EGFR NRAS NRAS E2F3 E2F3 SHC1 SHC1 SHC3 SHC3 LOC108541626 LOC108541626 IGF1R IGF1R BAD BAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
SRCTyrosine-protein kinase. (627 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
MAPK10Mitogen-activated protein kinase. (528 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1169 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2527 aa)
MMP9Matrix metallopeptidase 9. (703 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (748 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1075 aa)
DLL3Delta like canonical Notch ligand 3. (618 aa)
MAPK9Mitogen-activated protein kinase. (407 aa)
IGF1Insulin like growth factor 1. (208 aa)
ARAFA-Raf proto-oncogene, serine/threonine kinase. (606 aa)
SHC2Uncharacterized protein. (421 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
CARM1Coactivator associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (582 aa)
RAF1Uncharacterized protein. (668 aa)
NOTCH4Notch receptor 4. (2000 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
NCOA3Nuclear receptor coactivator. (1418 aa)
SHC4SHC adaptor protein 4. (630 aa)
GPER1G protein-coupled estrogen receptor 1. (373 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1547 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1080 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
RB1RB transcriptional corepressor 1. (815 aa)
MMP2Matrix metallopeptidase 2. (660 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (753 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
ADCY8Adenylate cyclase 8; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (657 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CCND1Cyclin D1. (156 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
ESR2Estrogen receptor 2. (530 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
E2F2E2F transcription factor 2. (437 aa)
MAPK13Mitogen-activated protein kinase. (365 aa)
ABCB11ATP binding cassette subfamily B member 11. (1309 aa)
BIKBCL2 interacting killer. (157 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1293 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1085 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
NCOR1Nuclear receptor corepressor 1. (2441 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1118 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
NOTCH2Notch receptor 2. (2532 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1268 aa)
GNASGNAS complex locus. (1041 aa)
EGFRReceptor protein-tyrosine kinase. (1210 aa)
NRASNRAS proto-oncogene, GTPase. (189 aa)
E2F3E2F transcription factor 3. (465 aa)
SHC1SHC adaptor protein 1. (584 aa)
SHC3SHC adaptor protein 3. (596 aa)
LOC108541626Uncharacterized protein. (246 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
BADBCL2 associated agonist of cell death. (167 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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