(28 nodes) Antifolate resistance network (Rhinopithecus bieti)

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second shell of interactors

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Your Input:
	MTHFR	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (697 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (969 aa)
	ABCG2	ABC transporter domain-containing protein. (672 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (483 aa)
	IKBKG	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (347 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
	RELA	Uncharacterized protein. (282 aa)
	LOC108524794	ABC transmembrane type-1 domain-containing protein. (492 aa)
	IZUMO1R	IZUMO1 receptor, JUNO. (250 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
	ABCC2	ATP binding cassette subfamily C member 2. (1545 aa)
	ABCC3	ATP binding cassette subfamily C member 3. (1527 aa)
	IKBKB	Inhibitor of nuclear factor kappa B kinase subunit beta. (789 aa)
	ABCC4	ATP binding cassette subfamily C member 4. (1325 aa)
	FOLR3	Folate receptor gamma. (261 aa)
	DHFR	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
	FOLR1	Folate receptor alpha. (257 aa)
	ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (591 aa)
	TYMS	Thymidylate synthetase. (313 aa)
	SLC46A1	Solute carrier family 46 member 1. (459 aa)
	SLC19A1	Solute carrier family 19 member 1. (721 aa)
	GGH	Folate gamma-glutamyl hydrolase. (318 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
	IL6	Interleukin 6. (214 aa)
	ABCC1	ATP binding cassette subfamily C member 1. (1531 aa)
	GART	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
	ALOX12	Arachidonate 12-lipoxygenase, 12S type. (663 aa)

Your Current Organism:

Rhinopithecus bieti

NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCC1	ABCG2	ENSRBIP00000041587	ENSRBIP00000014615	ATP binding cassette subfamily C member 1.	ABC transporter domain-containing protein.	0.731
ABCC2	ABCG2	ENSRBIP00000024395	ENSRBIP00000014615	ATP binding cassette subfamily C member 2.	ABC transporter domain-containing protein.	0.865
ABCC3	ABCG2	ENSRBIP00000026047	ENSRBIP00000014615	ATP binding cassette subfamily C member 3.	ABC transporter domain-containing protein.	0.530
ABCC4	ABCG2	ENSRBIP00000028407	ENSRBIP00000014615	ATP binding cassette subfamily C member 4.	ABC transporter domain-containing protein.	0.445
ABCG2	ABCC1	ENSRBIP00000014615	ENSRBIP00000041587	ABC transporter domain-containing protein.	ATP binding cassette subfamily C member 1.	0.731
ABCG2	ABCC2	ENSRBIP00000014615	ENSRBIP00000024395	ABC transporter domain-containing protein.	ATP binding cassette subfamily C member 2.	0.865
ABCG2	ABCC3	ENSRBIP00000014615	ENSRBIP00000026047	ABC transporter domain-containing protein.	ATP binding cassette subfamily C member 3.	0.530
ABCG2	ABCC4	ENSRBIP00000014615	ENSRBIP00000028407	ABC transporter domain-containing protein.	ATP binding cassette subfamily C member 4.	0.445
ATIC	DHFR	ENSRBIP00000033563	ENSRBIP00000032697	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.939
ATIC	GART	ENSRBIP00000033563	ENSRBIP00000041728	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.999
ATIC	GGH	ENSRBIP00000033563	ENSRBIP00000039879	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Folate gamma-glutamyl hydrolase.	0.574
ATIC	MTHFR	ENSRBIP00000033563	ENSRBIP00000005258	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.733
ATIC	SHMT1	ENSRBIP00000033563	ENSRBIP00000015103	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.991
ATIC	SHMT2	ENSRBIP00000033563	ENSRBIP00000039957	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.991
ATIC	TYMS	ENSRBIP00000033563	ENSRBIP00000034054	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Thymidylate synthetase.	0.724
CHUK	IKBKB	ENSRBIP00000023948	ENSRBIP00000027811	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.999
CHUK	IKBKG	ENSRBIP00000023948	ENSRBIP00000015173	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.	0.999
CHUK	IL1B	ENSRBIP00000023948	ENSRBIP00000017788	Component of inhibitor of nuclear factor kappa B kinase complex.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.554
CHUK	IL6	ENSRBIP00000023948	ENSRBIP00000041408	Component of inhibitor of nuclear factor kappa B kinase complex.	Interleukin 6.	0.436
CHUK	NFKB1	ENSRBIP00000023948	ENSRBIP00000012337	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor kappa B subunit 1.	0.991