STRINGSTRING
LOC108524923 LOC108524923 LOC108535521 LOC108535521 MAPK3 MAPK3 LOC108516321 LOC108516321 MSH3 MSH3 PIK3R1 PIK3R1 PIK3R3 PIK3R3 FASLG FASLG LOC108533297 LOC108533297 LOC108523439 LOC108523439 BIRC3 BIRC3 MSH6 MSH6 LOC108523776 LOC108523776 TOP2B TOP2B APAF1 APAF1 ENSRBIP00000005595 ENSRBIP00000005595 SLC31A1 SLC31A1 MLH1 MLH1 TOP2A TOP2A GSTA1 GSTA1 LOC108524063 LOC108524063 POLH POLH BID BID BCL2 BCL2 PMAIP1 PMAIP1 BIRC2 BIRC2 ATP7B ATP7B MGST2 MGST2 CASP9 CASP9 MSH2 MSH2 PIK3CA PIK3CA GSTM3 GSTM3 ATM ATM GSTA3 GSTA3 GSTO1 GSTO1 LOC108524065 LOC108524065 ABCC2 ABCC2 XPA XPA FADD FADD MAPK1 MAPK1 BIRC5 BIRC5 TP53 TP53 FAS FAS MAP3K5 MAP3K5 ERBB2 ERBB2 GSTO2 GSTO2 AKT2 AKT2 AKT3 AKT3 GSTA4 GSTA4 REV3L REV3L PIK3CD PIK3CD GSTP1 GSTP1 BAX BAX BAK1 BAK1 MGST3 MGST3 BRCA1 BRCA1 BAD BAD CASP8 CASP8
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108524923Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC108535521Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (378 aa)
LOC108516321Uncharacterized protein; Belongs to the GST superfamily. (241 aa)
MSH3MutS homolog 3. (1195 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
PIK3R3Phosphoinositide-3-kinase regulatory subunit 3. (461 aa)
FASLGFas ligand; Belongs to the tumor necrosis factor family. (280 aa)
LOC108533297Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
LOC108523439Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
BIRC3Baculoviral IAP repeat containing 3. (604 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1305 aa)
LOC108523776Uncharacterized protein. (150 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1559 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1228 aa)
ENSRBIP00000005595Uncharacterized protein. (140 aa)
SLC31A1Solute carrier family 31 member 1. (190 aa)
MLH1MutL homolog 1. (754 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1515 aa)
GSTA1Glutathione S-transferase. (222 aa)
LOC108524063Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
POLHDNA polymerase eta. (697 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
PMAIP1Uncharacterized protein. (133 aa)
BIRC2Baculoviral IAP repeat containing 2. (618 aa)
ATP7BATPase copper transporting beta. (1568 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (372 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
GSTM3Glutathione S-transferase. (225 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3026 aa)
GSTA3Glutathione S-transferase alpha 3. (222 aa)
GSTO1Uncharacterized protein. (241 aa)
LOC108524065Uncharacterized protein; Belongs to the GST superfamily. (240 aa)
ABCC2ATP binding cassette subfamily C member 2. (1545 aa)
XPAXPA, DNA damage recognition and repair factor. (303 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (208 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (342 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (393 aa)
FASFas cell surface death receptor. (331 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1374 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (243 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
AKT3AKT serine/threonine kinase 3; Belongs to the protein kinase superfamily. (389 aa)
GSTA4Glutathione S-transferase alpha 4; Belongs to the GST superfamily. (222 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3106 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
GSTP1Glutathione S-transferase pi 1; Belongs to the GST superfamily. (210 aa)
BAXBCL2 associated X, apoptosis regulator. (197 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
MGST3Microsomal glutathione S-transferase 3. (166 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1818 aa)
BADBCL2 associated agonist of cell death. (167 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (542 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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