STRINGSTRING
BRCA2 BRCA2 BRIP1 BRIP1 FANCA FANCA RMI1 RMI1 MLH1 MLH1 POLH POLH PALB2 PALB2 CENPS-CORT CENPS-CORT BLM BLM TOP3A TOP3A ERCC4 ERCC4 REV1 REV1 RAD51C RAD51C WDR48 WDR48 POLI POLI FANCG FANCG EME1 EME1 FAN1 FAN1 TOP3B TOP3B SLX1A SLX1A CENPX CENPX FANCL FANCL RPA2 RPA2 RPA1 RPA1 POLK POLK ATR ATR UBE2T UBE2T RMI2 RMI2 FAAP100 FAAP100 TELO2 TELO2 RAD51 RAD51 SLX4 SLX4 RPA3 RPA3 MUS81 MUS81 REV3L REV3L USP1 USP1 FAAP24 FAAP24 BRCA1 BRCA1 ATRIP ATRIP FANCE FANCE FANCC FANCC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BRCA2Uncharacterized protein. (386 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (1226 aa)
FANCAFA complementation group A. (1375 aa)
RMI1RecQ mediated genome instability 1. (625 aa)
MLH1MutL homolog 1. (754 aa)
POLHDNA polymerase eta. (697 aa)
PALB2Partner and localizer of BRCA2. (1149 aa)
CENPS-CORTCENPS-CORT readthrough. (143 aa)
BLMBLM RecQ like helicase. (1396 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1001 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (907 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1241 aa)
RAD51CRAD51 paralog C. (376 aa)
WDR48WD repeat domain 48. (644 aa)
POLIDNA polymerase iota. (738 aa)
FANCGFA complementation group G. (622 aa)
EME1Essential meiotic structure-specific endonuclease 1. (571 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1017 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa)
CENPXCentromere protein X. (133 aa)
FANCLFA complementation group L. (383 aa)
RPA2Replication protein A2. (273 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
POLKDNA polymerase kappa. (866 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2578 aa)
UBE2TUbiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (240 aa)
RMI2RecQ mediated genome instability 2. (150 aa)
FAAP100FA core complex associated protein 100. (881 aa)
TELO2Telomere maintenance 2. (836 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (337 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1814 aa)
RPA3Replication protein A3. (121 aa)
MUS81MUS81 structure-specific endonuclease subunit. (551 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (3106 aa)
USP1Ubiquitin specific peptidase 1; Belongs to the peptidase C19 family. (773 aa)
FAAP24FA core complex associated protein 24. (215 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1818 aa)
ATRIPATR interacting protein. (790 aa)
FANCEFA complementation group E. (536 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (558 aa)
Your Current Organism:
Rhinopithecus bieti
NCBI taxonomy Id: 61621
Other names: Pygathrix bieti, R. bieti, black snub-nosed monkey
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